SEPTIN5 and SEPTIN4

Number of citations: 45 (PubMedID 15214843)
Data Source: HPRD (two hybrid)

		SEPTIN5	SEPTIN4
Name		septin 5	septin 4
Structure
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Plasma Membrane Septin Ring Synaptic Vesicle Microtubule Cytoskeleton Septin Complex Cell Division Site	Nucleus Cytoplasm Mitochondrion Mitochondrial Outer Membrane Cytosol Cilium Septin Ring Synaptic Vesicle Microtubule Cytoskeleton Transport Vesicle Axon Dendrite Septin Complex Cytoplasmic Vesicle Motile Cilium Cell Division Site Cell Projection Perikaryon Synapse Sperm Annulus Dopaminergic Synapse Presynapse
	Molecular Function	Nucleotide Binding GTPase Activity Structural Molecule Activity Protein Binding GTP Binding Identical Protein Binding Molecular Adaptor Activity	Nucleotide Binding Magnesium Ion Binding GTPase Activity Structural Molecule Activity Protein Binding GTP Binding Identical Protein Binding Molecular Adaptor Activity
	Biological Process	Intracellular Protein Localization Synaptic Vesicle Targeting Regulation Of Exocytosis Adult Behavior Social Behavior Cell Division Cytoskeleton-dependent Cytokinesis Regulation Of Synaptic Vesicle Exocytosis	Neuron Migration Apoptotic Process Spermatogenesis Intracellular Protein Localization Regulation Of Exocytosis Cell Differentiation Flagellated Sperm Motility Positive Regulation Of Protein Ubiquitination Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Spermatid Differentiation Cell Division Hematopoietic Stem Cell Homeostasis Cytoskeleton-dependent Cytokinesis Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
GWAS		No GWAS studies recorded	No GWAS studies recorded
Novel Interactors		1 novel interactors: PRODH	None recorded
Interacting Genes		21 interacting genes: APP CDK5R1 DDIT4L KAT7 KIDINS220 LSM8 MAGEA2 MAGEA2B MAPK6 MYOG PFN2 PLEKHF2 PRKN SEPTIN1 SEPTIN2 SEPTIN4 SEPTIN7 SEPTIN8 SPG21 STX1A STX4	10 interacting genes: AREL1 BCL2 PRKN SEPTIN5 SEPTIN8 SNCA SNCAIP SNCB TSC2 XIAP
Entrez ID		5413	5414
HPRD ID		04100	04738
Ensembl ID		ENSG00000184702	ENSG00000108387
Uniprot IDs		Q99719 X5DNA9	J3KSZ7 O43236
PDB IDs		6WCU	6WB3
GO Terms Enriched among Interactors		Septin Ring Septin Complex Cell Division Site Sperm Annulus Cytoskeleton-dependent Cytokinesis Regulation Of Exocytosis Regulation Of Vesicle-mediated Transport Molecular Adaptor Activity Presynapse Axon Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Regulation Of Protein Localization Positive Regulation Of Protein Ubiquitination Negative Regulation Of Protein Acetylation Microtubule Cytoskeleton Regulation Of Spontaneous Synaptic Transmission Synaptic Vesicle Positive Regulation Of Post-translational Protein Modification Modulation Of Excitatory Postsynaptic Potential Regulation Of Establishment Of Protein Localization GTPase Activity Cellular Response To Manganese Ion Neuron Projection Regulation Of Secretion By Cell Negative Regulation Of Protein Sumoylation Regulation Of Transport GTP Binding Regulation Of Intrinsic Apoptotic Signaling Pathway Cell Projection Regulation Of Secretion Positive Regulation Of Protein Modification Process Regulation Of Protein Ubiquitination SNARE Complex Assembly Regulation Of Apoptotic Signaling Pathway Synapse Regulation Of Protein Modification Process Positive Regulation Of Ubiquitin-protein Transferase Activity Dopaminergic Synapse Regulation Of Amine Transport Response To Manganese Ion Intracellular Protein Localization Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Neurotransmitter Secretion Regulation Of Protein Transport Postsynapse Collateral Sprouting Cellular Response To Catecholamine Stimulus Regulation Of Post-translational Protein Modification Neurotransmitter Transport Schaffer Collateral - CA1 Synapse	Phenol-containing Compound Metabolic Process Dopamine Metabolic Process Catecholamine Metabolic Process Biogenic Amine Metabolic Process Amine Metabolic Process Regulation Of Neurotransmitter Secretion Cell Death Positive Regulation Of Protein Linear Polyubiquitination Neuron Apoptotic Process Synaptic Vesicle Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Apoptotic Process Molecular Adaptor Activity Apoptotic Process Negative Regulation Of Programmed Cell Death Programmed Cell Death Dopamine Uptake Involved In Synaptic Transmission Regulation Of Transport Regulation Of Neuron Apoptotic Process Cuprous Ion Binding Protein Polyubiquitination Catecholamine Uptake Dopamine Uptake Septin Ring Septin Complex Negative Regulation Of Autophagy Cell Division Site Synaptic Transmission, Dopaminergic Regulation Of SNARE Complex Assembly Neuronal Cell Body Regulation Of Protein Stability Regulation Of Autophagy Positive Regulation Of Protein Polyubiquitination Regulation Of Apoptotic Process Dopamine Transport Neurotransmitter Reuptake Synaptic Vesicle Membrane Regulation Of Neurotransmitter Uptake Regulation Of Dopamine Metabolic Process Inclusion Body Regulation Of Programmed Cell Death Phospholipase Binding Adult Behavior Regulation Of Dopamine Secretion Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Synapse Regulation Of Protein Polyubiquitination Modulation Of Chemical Synaptic Transmission Monoamine Transport Amyloid Fibril Formation