SEPTIN5 and STX4

Number of citations: 35 (PubMedID 11880646)
Data Source: BioGRID (affinity chromatography technology), HPRD (in vitro)

		SEPTIN5	STX4
Name		septin 5	syntaxin 4
Structure			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Plasma Membrane Septin Ring Synaptic Vesicle Microtubule Cytoskeleton Septin Complex Cell Division Site	Storage Vacuole Extracellular Space Cytoplasm Endosome Vacuole Trans-Golgi Network Cytosol Plasma Membrane Cell Surface Endomembrane System Membrane Basolateral Plasma Membrane Lamellipodium Phagocytic Vesicle Membrane SNARE Complex Stereocilium Neuron Projection Membrane Myelin Sheath Adaxonal Region Somatodendritic Compartment Specific Granule Cell Projection Neuron Projection Dendritic Spine Lateral Loop Synapse Phagocytic Vesicle Perinuclear Region Of Cytoplasm Extracellular Exosome Schaffer Collateral - CA1 Synapse Postsynapse Glutamatergic Synapse
	Molecular Function	Nucleotide Binding GTPase Activity Structural Molecule Activity Protein Binding GTP Binding Identical Protein Binding Molecular Adaptor Activity	SNARE Binding SNAP Receptor Activity Protein Binding Sphingomyelin Phosphodiesterase Activator Activity
	Biological Process	Intracellular Protein Localization Synaptic Vesicle Targeting Regulation Of Exocytosis Adult Behavior Social Behavior Cell Division Cytoskeleton-dependent Cytokinesis Regulation Of Synaptic Vesicle Exocytosis	Positive Regulation Of Immunoglobulin Production Neurotransmitter Transport Intracellular Protein Transport Exocytosis Vesicle Fusion Sensory Perception Of Sound Positive Regulation Of Cell Population Proliferation Vesicle-mediated Transport Regulation Of Exocytosis Positive Regulation Of Cell Migration Protein Localization To Cell Surface Cellular Response To Oxidative Stress SNARE Complex Assembly Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Positive Regulation Of Catalytic Activity Positive Regulation Of Eosinophil Degranulation Positive Regulation Of Cell Adhesion Vesicle Docking Organelle Fusion Positive Regulation Of Chemotaxis Long-term Synaptic Potentiation Membrane Organization Cellular Response To Type II Interferon Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Protein Localization To Plasma Membrane Cornified Envelope Assembly Positive Regulation Of Protein Localization To Cell Surface
Pathways		None	Disinhibition of SNARE formation ER-Phagosome pathway Translocation of SLC2A4 (GLUT4) to the plasma membrane trans-Golgi Network Vesicle Budding Other interleukin signaling
GWAS		No GWAS studies recorded	Response to metformin (IC50) ( 28173075 ) Triglyceride levels ( 32203549 )
Interacting Genes		21 interacting genes: APP CDK5R1 DDIT4L KAT7 KIDINS220 LSM8 MAGEA2 MAGEA2B MAPK6 MYOG PFN2 PLEKHF2 PRKN SEPTIN1 SEPTIN2 SEPTIN4 SEPTIN7 SEPTIN8 SPG21 STX1A STX4	65 interacting genes: ABI2 ACTB ANKRD46 BET1 CYBRD1 DLG1 DNAJC5 FAXDC2 GIMAP5 GOSR2 GPR152 ITSN2 LLGL1 LMNA NAPA NAPB NSF PLP1 PSMA3 RAB11A RAB4A RAB5A RNF4 SCRIB SEC22A SEC22B SEPTIN5 SERP1 SGPL1 SH3GLB2 SNAP23 SNAP25 SNAP47 STX10 STX11 STX16 STX1A STX1B STX2 STX3 STX5 STXBP3 STXBP4 STXBP5 STXBP6 SYT1 SYT4 SYT7 TCEANC TMEM203 TRAF3IP3 TXLNA TXLNB TXLNG USE1 VAMP1 VAMP2 VAMP3 VAMP4 VAMP7 VAMP8 VAPB VMA12 VTI1B ZFPL1
Entrez ID		5413	6810
HPRD ID		04100	01722
Ensembl ID		ENSG00000184702	ENSG00000103496
Uniprot IDs		Q99719 X5DNA9	B7Z425 Q12846
PDB IDs		6WCU	Not available
GO Terms Enriched among Interactors		Septin Ring Septin Complex Cell Division Site Sperm Annulus Cytoskeleton-dependent Cytokinesis Regulation Of Exocytosis Regulation Of Vesicle-mediated Transport Molecular Adaptor Activity Presynapse Axon Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Regulation Of Protein Localization Positive Regulation Of Protein Ubiquitination Negative Regulation Of Protein Acetylation Microtubule Cytoskeleton Regulation Of Spontaneous Synaptic Transmission Synaptic Vesicle Positive Regulation Of Post-translational Protein Modification Modulation Of Excitatory Postsynaptic Potential Regulation Of Establishment Of Protein Localization GTPase Activity Cellular Response To Manganese Ion Neuron Projection Regulation Of Secretion By Cell Negative Regulation Of Protein Sumoylation Regulation Of Transport GTP Binding Regulation Of Intrinsic Apoptotic Signaling Pathway Cell Projection Regulation Of Secretion Positive Regulation Of Protein Modification Process Regulation Of Protein Ubiquitination SNARE Complex Assembly Regulation Of Apoptotic Signaling Pathway Synapse Regulation Of Protein Modification Process Positive Regulation Of Ubiquitin-protein Transferase Activity Dopaminergic Synapse Regulation Of Amine Transport Response To Manganese Ion Intracellular Protein Localization Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Neurotransmitter Secretion Regulation Of Protein Transport Postsynapse Collateral Sprouting Cellular Response To Catecholamine Stimulus Regulation Of Post-translational Protein Modification Neurotransmitter Transport Schaffer Collateral - CA1 Synapse	SNAP Receptor Activity SNARE Complex Membrane Fusion Syntaxin Binding Vesicle Fusion Organelle Membrane Fusion Organelle Fusion Vesicle-mediated Transport Membrane Organization SNARE Binding Vesicle Organization Exocytosis Organelle Localization By Membrane Tethering Establishment Of Localization In Cell Membrane Docking Secretion By Cell Vesicle Docking Protein Transport Secretion Establishment Of Protein Localization Vesicle-mediated Transport In Synapse Golgi Vesicle Transport Cellular Localization Intracellular Protein Localization Intracellular Transport Organelle Localization Regulation Of Vesicle-mediated Transport Endomembrane System Calcium-ion Regulated Exocytosis SNARE Complex Assembly Membrane Regulated Exocytosis Regulation Of Exocytosis Syntaxin-1 Binding Synaptic Vesicle Exocytosis Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Intracellular Protein Transport Vesicle Fusion To Plasma Membrane Regulation Of Secretion By Cell Synaptic Vesicle Membrane Regulation Of Secretion Synaptic Vesicle Membrane Organization Signal Release Regulation Of Transport Regulation Of Regulated Secretory Pathway Synaptic Vesicle Calcium Ion-regulated Exocytosis Of Neurotransmitter Vesicle Docking Involved In Exocytosis Synaptobrevin 2-SNAP-25-syntaxin-1a Complex Post-Golgi Vesicle-mediated Transport