SEPTIN5 and PRODH

Data Source: HiPPIP (Novel)

		SEPTIN5	PRODH
Name		septin 5	proline dehydrogenase 1
Structure			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Plasma Membrane Septin Ring Synaptic Vesicle Microtubule Cytoskeleton Septin Complex Cell Division Site	Nucleoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix
	Molecular Function	Nucleotide Binding GTPase Activity Structural Molecule Activity Protein Binding GTP Binding Identical Protein Binding Molecular Adaptor Activity	Proline Dehydrogenase Activity Oxidoreductase Activity FAD Binding
	Biological Process	Intracellular Protein Localization Synaptic Vesicle Targeting Regulation Of Exocytosis Adult Behavior Social Behavior Cell Division Cytoskeleton-dependent Cytokinesis Regulation Of Synaptic Vesicle Exocytosis	Proline Metabolic Process L-proline Catabolic Process Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress L-proline Catabolic Process To L-glutamate Trans-4-hydroxy-L-proline Catabolic Process Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway
Pathways		None	Proline catabolism
Drugs		None	Proline
Diseases		None	Hyperprolinemia (HP)
GWAS		No GWAS studies recorded	Metabolic traits ( 21886157 ) Metabolite levels ( 31628463 ) Neutrophil count ( 32888494 ) Plasma free amino acid levels (adjusted for one other PFAA) ( 30659259 ) Plasma free amino acid levels (adjusted for twenty other PFAAs) ( 30659259 ) Plasma free proline levels ( 30659259 ) Platelet count ( 32888494 ) Serum metabolite concentrations in chronic kidney disease ( 29545352 ) Serum metabolite levels ( 25569235 33031748 ) White blood cell count ( 32888494 )
Novel Interactors		1 novel interactors: PRODH	7 novel interactors: GGT3P GSC2 ITM2C RANBP1 SEPTIN5 SKIC2 TBX1
Interacting Genes		21 interacting genes: APP CDK5R1 DDIT4L KAT7 KIDINS220 LSM8 MAGEA2 MAGEA2B MAPK6 MYOG PFN2 PLEKHF2 PRKN SEPTIN1 SEPTIN2 SEPTIN4 SEPTIN7 SEPTIN8 SPG21 STX1A STX4	None recorded
Entrez ID		5413	5625
HPRD ID		04100	08433
Ensembl ID		ENSG00000184702	ENSG00000100033
Uniprot IDs		Q99719 X5DNA9	E7EQL6 O43272
PDB IDs		6WCU	Not available
GO Terms Enriched among Interactors		Septin Ring Septin Complex Cell Division Site Sperm Annulus Cytoskeleton-dependent Cytokinesis Regulation Of Exocytosis Regulation Of Vesicle-mediated Transport Molecular Adaptor Activity Presynapse Axon Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Regulation Of Protein Localization Positive Regulation Of Protein Ubiquitination Negative Regulation Of Protein Acetylation Microtubule Cytoskeleton Regulation Of Spontaneous Synaptic Transmission Synaptic Vesicle Positive Regulation Of Post-translational Protein Modification Modulation Of Excitatory Postsynaptic Potential Regulation Of Establishment Of Protein Localization GTPase Activity Cellular Response To Manganese Ion Neuron Projection Regulation Of Secretion By Cell Negative Regulation Of Protein Sumoylation Regulation Of Transport GTP Binding Regulation Of Intrinsic Apoptotic Signaling Pathway Cell Projection Regulation Of Secretion Positive Regulation Of Protein Modification Process Regulation Of Protein Ubiquitination SNARE Complex Assembly Regulation Of Apoptotic Signaling Pathway Synapse Regulation Of Protein Modification Process Positive Regulation Of Ubiquitin-protein Transferase Activity Dopaminergic Synapse Regulation Of Amine Transport Response To Manganese Ion Intracellular Protein Localization Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Neurotransmitter Secretion Regulation Of Protein Transport Postsynapse Collateral Sprouting Cellular Response To Catecholamine Stimulus Regulation Of Post-translational Protein Modification Neurotransmitter Transport Schaffer Collateral - CA1 Synapse	Social Behavior