TLR9 and MAPK8IP3

Number of citations of the paper that reports this interaction (PMID 12941697)
17

Data Source:
HPRD (in vivo)

		TLR9	MAPK8IP3
Gene Name		toll-like receptor 9	mitogen-activated protein kinase 8 interacting protein 3
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Extracellular Region Cytoplasm Lysosome Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Endosome Membrane Integral Component Of Membrane Basolateral Plasma Membrane Apical Plasma Membrane Early Phagosome Endolysosome Membrane	Golgi Membrane Cytoplasm Smooth Endoplasmic Reticulum Dendrite Axolemma
	Molecular Function	Transmembrane Signaling Receptor Activity Interleukin-1 Receptor Binding SiRNA Binding	MAP-kinase Scaffold Activity JUN Kinase Binding Kinesin Binding Receptor Signaling Complex Scaffold Activity Mitogen-activated Protein Kinase Kinase Binding Mitogen-activated Protein Kinase Kinase Kinase Binding
	Biological Process	Toll-like Receptor Signaling Pathway Response To Molecule Of Bacterial Origin MyD88-dependent Toll-like Receptor Signaling Pathway Inflammatory Response I-kappaB Phosphorylation Insulin Receptor Signaling Pathway Maintenance Of Gastrointestinal Epithelium Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Interleukin-6 Production Negative Regulation Of Interleukin-8 Production Positive Regulation Of Chemokine Production Positive Regulation Of Interferon-beta Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-18 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Toll-like Receptor Signaling Pathway Positive Regulation Of Toll-like Receptor Signaling Pathway Toll-like Receptor 9 Signaling Pathway Positive Regulation Of NF-kappaB Import Into Nucleus Defense Response To Bacterium Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of JUN Kinase Activity Positive Regulation Of Interferon-gamma Biosynthetic Process Innate Immune Response Positive Regulation Of Interferon-alpha Biosynthetic Process Positive Regulation Of Interferon-beta Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of JNK Cascade Regulation Of Cytokine Secretion Positive Regulation Of Inflammatory Response Defense Response To Gram-negative Bacterium Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process	In Utero Embryonic Development Activation Of JUN Kinase Activity Axon Guidance Respiratory Gaseous Exchange Protein Localization Post-embryonic Development Regulation Of Gene Expression Vesicle-mediated Transport Forebrain Development Positive Regulation Of Neuron Differentiation Regulation Of JNK Cascade Lung Alveolus Development Lung Morphogenesis
Pathways		Insulin receptor signalling cascade IRS-mediated signalling Toll Like Receptor 7/8 (TLR7/8) Cascade IRS-related events IGF1R signaling cascade IRS-related events triggered by IGF1R Trafficking and processing of endosomal TLR Toll-Like Receptors Cascades IRS-mediated signalling Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) MyD88 dependent cascade initiated on endosome TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling Toll Like Receptor 9 (TLR9) Cascade PI3K Cascade PI3K Cascade Innate Immune System Signaling by Insulin receptor
Drugs		Chloroquine Hydroxychloroquine
Diseases
GWAS		Bipolar disorder ( 21926972)
Protein-Protein Interactions		6 interactors: BTK HRAS MAPK8IP3 RNF216 SIGIRR TLR1	21 interactors: ARL4D CASP3 KLC1 KLC2 MAP2K1 MAP2K4 MAP2K7 MAP3K11 MAP3K5 MAPK10 MAPK8 MAPK8IP1 MAPK8IP2 MAPK9 PTK2 RAF1 RIC8A SRC TLR2 TLR4 TLR9
Entrez ID		54106	23162
HPRD ID		05685	12014
Ensembl ID		ENSG00000239732	ENSG00000138834
Uniprot IDs		Q9NR96	E9PFH7 Q9UPT6
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Cytokine Production Inflammatory Response Lung Morphogenesis Regulation Of Immune System Process MyD88-dependent Toll-like Receptor Signaling Pathway Defense Response Immune Response-regulating Signaling Pathway Toll-like Receptor 1 Signaling Pathway Regulation Of B Cell Cytokine Production Regulation Of Cytokine Biosynthetic Process Toll-like Receptor Signaling Pathway Response To Stress Positive Regulation Of JNK Cascade Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Response To External Stimulus Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Cellular Response To Molecule Of Fungal Origin Detection Of Triacyl Bacterial Lipopeptide Cellular Response To Triacyl Bacterial Lipopeptide Activation Of Innate Immune Response Regulation Of JNK Cascade Innate Immune Response Positive Regulation Of Innate Immune Response Regulation Of Immune Response Regulation Of Stress-activated MAPK Cascade Regulation Of Protein Metabolic Process Response To Molecule Of Fungal Origin Positive Regulation Of MAP Kinase Activity Positive Regulation Of Rac Protein Signal Transduction Negative Regulation Of Chemokine Biosynthetic Process Apoptotic Process Fc-epsilon Receptor Signaling Pathway MAPK Cascade Programmed Cell Death Positive Regulation Of MiRNA Metabolic Process Regulation Of Innate Immune Response Cell Death Death Positive Regulation Of Ruffle Assembly Detection Of Bacterial Lipoprotein Lung Development Respiratory Tube Development Fc Receptor Signaling Pathway Activation Of Protein Kinase Activity Positive Regulation Of Protein Serine/threonine Kinase Activity Signal Transduction By Phosphorylation Respiratory System Development Regulation Of MAP Kinase Activity	Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade MyD88-dependent Toll-like Receptor Signaling Pathway MAPK Cascade JNK Cascade Positive Regulation Of Signal Transduction Regulation Of Protein Kinase Activity Signal Transduction By Phosphorylation Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Regulation Of Kinase Activity Toll-like Receptor Signaling Pathway Toll-like Receptor 2 Signaling Pathway Regulation Of Stress-activated MAPK Cascade Regulation Of Protein Phosphorylation Regulation Of MAPK Cascade Immune Response-regulating Signaling Pathway Positive Regulation Of Protein Kinase Activity Intracellular Signal Transduction Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Positive Regulation Of Kinase Activity Positive Regulation Of Catalytic Activity Positive Regulation Of Protein Metabolic Process Activation Of Innate Immune Response Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Protein Phosphorylation Protein Phosphorylation Regulation Of Phosphorylation Positive Regulation Of Transferase Activity Regulation Of JNK Cascade Regulation Of Protein Metabolic Process Innate Immune Response Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cellular Protein Metabolic Process Regulation Of MAP Kinase Activity Response To Stress Positive Regulation Of Innate Immune Response Phosphorylation Positive Regulation Of MAPK Cascade Positive Regulation Of Phosphorylation Regulation Of Phosphorus Metabolic Process Regulation Of Catalytic Activity Positive Regulation Of Protein Modification Process Toll-like Receptor 9 Signaling Pathway Regulation Of Cellular Protein Metabolic Process TRIF-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of MAP Kinase Activity MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway
Tagcloud ?		bed cd14 constitutively fibroblast immunoassay immunocytochemistry lamina lipopolysaccharide lps md measuring microorganisms nucleus p65 polyp propria quantified respond responsiveness scar strategic supernatant tlr1 tlr4 tlrs toll vff vffs vocal
Tagcloud (Difference) ?		bed cd14 constitutively fibroblast immunoassay immunocytochemistry lamina lipopolysaccharide lps md measuring microorganisms nucleus p65 polyp propria quantified respond responsiveness scar strategic supernatant tlr1 tlr4 tlrs toll vff vffs vocal
Tagcloud (Intersection) ?