PCSK6 and FLG

Number of citations of the paper that reports this interaction (PMID 11380615)
15

Data Source:
HPRD (in vitro)

		PCSK6	FLG
Gene Name		proprotein convertase subtilisin/kexin type 6	filaggrin
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Endoplasmic Reticulum Golgi Lumen Cell Surface Membrane Extracellular Matrix	Nucleus Intermediate Filament Cytoplasmic Membrane-bounded Vesicle
	Molecular Function	Endopeptidase Activity Serine-type Endopeptidase Activity Heparin Binding Nerve Growth Factor Binding	Structural Molecule Activity Calcium Ion Binding Protein Binding
	Biological Process	Proteolysis Zygotic Determination Of Anterior/posterior Axis, Embryo Determination Of Left/right Symmetry Glycoprotein Metabolic Process Protein Processing Peptide Hormone Processing Regulation Of BMP Signaling Pathway Nerve Growth Factor Processing Nerve Growth Factor Production Secretion By Cell Neurotrophin TRK Receptor Signaling Pathway	Multicellular Organismal Development Keratinocyte Differentiation Establishment Of Skin Barrier
Pathways		Signalling by NGF NGF processing Signaling by NODAL
Drugs
Diseases
GWAS		Handedness in dyslexia ( 21051773)	Atopic dermatitis ( 21666691) Eating disorders ( 23568457)
Protein-Protein Interactions		4 interactors: CACNA1A FLG PMCH RCN3	3 interactors: CSNK2A1 PCSK6 UCHL5
Entrez ID		5046	2312
HPRD ID		01329	15920
Ensembl ID		ENSG00000140479	ENSG00000143631
Uniprot IDs		P29122	P20930
PDB IDs
Enriched GO Terms of Interacting Partners?		Cell-cell Signaling Cerebellar Molecular Layer Development Vestibular Nucleus Development Cerebellum Maturation Musculoskeletal Movement, Spinal Reflex Action Gamma-aminobutyric Acid Secretion Regulation Of Lateral Mesodermal Cell Fate Specification Fibroblast Growth Factor Receptor Signaling Pathway Involved In Orbitofrontal Cortex Development Ventricular Zone Neuroblast Division Regulation Of Acetylcholine Secretion, Neurotransmission Orbitofrontal Cortex Development Rhythmic Synaptic Transmission Regulation Of Neuron Projection Development Forebrain Ventricular Zone Progenitor Cell Division Positive Regulation Of MAPKKK Cascade By Fibroblast Growth Factor Receptor Signaling Pathway Calcium Ion-dependent Exocytosis Of Neurotransmitter Cellular Chloride Ion Homeostasis Gamma-aminobutyric Acid Transport Chloride Ion Homeostasis Outer Ear Morphogenesis Regulation Of Branching Involved In Salivary Gland Morphogenesis By Mesenchymal-epithelial Signaling Regulation Of Cell Projection Organization Negative Regulation Of Hormone Biosynthetic Process Pons Development Regulation Of Neuron Differentiation Cell Morphogenesis Involved In Neuron Differentiation Synaptic Transmission Cerebellar Purkinje Cell Differentiation Mesenchymal-epithelial Cell Signaling Behavior Forebrain Neuroblast Division Regulation Of Branching Involved In Salivary Gland Morphogenesis Neuron Projection Morphogenesis Establishment Of Skin Barrier Cerebellar Purkinje Cell Layer Morphogenesis Auditory Receptor Cell Development Lung-associated Mesenchyme Development Cell Surface Receptor Signaling Pathway Regulation Of Cell Fate Specification Regulation Of Water Loss Via Skin Regulation Of Neurogenesis Reflex Cell Morphogenesis Involved In Differentiation Behavioral Response To Pain Neuromuscular Synaptic Transmission Cell Differentiation Brain Development Regulation Of Hormone Biosynthetic Process Paraxial Mesoderm Development Middle Ear Morphogenesis	Regulation Of Proteasomal Protein Catabolic Process Nerve Growth Factor Production Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Zygotic Determination Of Anterior/posterior Axis, Embryo Nerve Growth Factor Processing Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Regulation Of Endopeptidase Activity Regulation Of Protein Catabolic Process Negative Regulation Of Hydrolase Activity Regulation Of Protein Processing Regulation Of Peptidase Activity Regulation Of Signal Transduction Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Signaling Regulation Of Proteolysis Cell Surface Receptor Signaling Pathway Anterior/posterior Axis Specification, Embryo Forebrain Morphogenesis Lateral Ventricle Development Negative Regulation Of Catalytic Activity Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Peptide Hormone Processing Mitotic Spindle Checkpoint Negative Regulation Of Chromosome Segregation Brain Morphogenesis Ventricular System Development Spindle Checkpoint Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Mitotic Nuclear Division Regulation Of Mitotic Metaphase/anaphase Transition Embryonic Axis Specification Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Chaperone-mediated Protein Folding Multicellular Organismal Development Negative Regulation Of Proteasomal Protein Catabolic Process Anterior/posterior Axis Specification Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Anatomical Structure Development Negative Regulation Of Cellular Protein Catabolic Process Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Cell Division Regulation Of Chromosome Segregation Regulation Of BMP Signaling Pathway Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Midbrain Development
Tagcloud ?		absent astrocytic cadherin candidate cdh11 convertase endocytosis functionally glioblastoma glioblastomas glioma gliomas immunoreactivity infiltrating infiltration infiltrative invasion kexin microdissected ontology proprotein rich sh3 sh3gl3 subtilisin tumour validate validated zone	activating adaptor associates autocrine becomes constitutive exchange expected fgf fgfr fibroblast gamma grb2 guanine instead neither nucleotide p90 phospholipase phosphorylated plc ras shc sos src suramin transformed tyrosine v
Tagcloud (Difference) ?		absent astrocytic cadherin candidate cdh11 convertase endocytosis functionally glioblastoma glioblastomas glioma gliomas immunoreactivity infiltrating infiltration infiltrative invasion kexin microdissected ontology proprotein rich sh3 sh3gl3 subtilisin tumour validate validated zone	activating adaptor associates autocrine becomes constitutive exchange expected fgf fgfr fibroblast gamma grb2 guanine instead neither nucleotide p90 phospholipase phosphorylated plc ras shc sos src suramin transformed tyrosine v
Tagcloud (Intersection) ?