PCSK6 and RCN3

Number of citations of the paper that reports this interaction (PMID 16433634)
6

Data Source:
HPRD (in vivo)

		PCSK6	RCN3
Gene Name		proprotein convertase subtilisin/kexin type 6	reticulocalbin 3, EF-hand calcium binding domain
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Endoplasmic Reticulum Golgi Lumen Cell Surface Membrane Extracellular Matrix	Endoplasmic Reticulum Lumen
	Molecular Function	Endopeptidase Activity Serine-type Endopeptidase Activity Heparin Binding Nerve Growth Factor Binding	Calcium Ion Binding Protein Binding
	Biological Process	Proteolysis Zygotic Determination Of Anterior/posterior Axis, Embryo Determination Of Left/right Symmetry Glycoprotein Metabolic Process Protein Processing Peptide Hormone Processing Regulation Of BMP Signaling Pathway Nerve Growth Factor Processing Nerve Growth Factor Production Secretion By Cell Neurotrophin TRK Receptor Signaling Pathway
Pathways		Signalling by NGF NGF processing Signaling by NODAL
Drugs
Diseases
GWAS		Handedness in dyslexia ( 21051773)	Hematological and biochemical traits ( 20139978)
Protein-Protein Interactions		4 interactors: CACNA1A FLG PMCH RCN3	9 interactors: HID1 KLHL42 MBD3 MKNK1 PACRGL PCSK6 PRUNE2 STAT6 SUFU
Entrez ID		5046	57333
HPRD ID		01329	17962
Ensembl ID		ENSG00000140479	ENSG00000142552
Uniprot IDs		P29122	Q96D15
PDB IDs
Enriched GO Terms of Interacting Partners?		Cell-cell Signaling Cerebellar Molecular Layer Development Vestibular Nucleus Development Cerebellum Maturation Musculoskeletal Movement, Spinal Reflex Action Gamma-aminobutyric Acid Secretion Regulation Of Lateral Mesodermal Cell Fate Specification Fibroblast Growth Factor Receptor Signaling Pathway Involved In Orbitofrontal Cortex Development Ventricular Zone Neuroblast Division Regulation Of Acetylcholine Secretion, Neurotransmission Orbitofrontal Cortex Development Rhythmic Synaptic Transmission Regulation Of Neuron Projection Development Forebrain Ventricular Zone Progenitor Cell Division Positive Regulation Of MAPKKK Cascade By Fibroblast Growth Factor Receptor Signaling Pathway Calcium Ion-dependent Exocytosis Of Neurotransmitter Cellular Chloride Ion Homeostasis Gamma-aminobutyric Acid Transport Chloride Ion Homeostasis Outer Ear Morphogenesis Regulation Of Branching Involved In Salivary Gland Morphogenesis By Mesenchymal-epithelial Signaling Regulation Of Cell Projection Organization Negative Regulation Of Hormone Biosynthetic Process Pons Development Regulation Of Neuron Differentiation Cell Morphogenesis Involved In Neuron Differentiation Synaptic Transmission Cerebellar Purkinje Cell Differentiation Mesenchymal-epithelial Cell Signaling Behavior Forebrain Neuroblast Division Regulation Of Branching Involved In Salivary Gland Morphogenesis Neuron Projection Morphogenesis Establishment Of Skin Barrier Cerebellar Purkinje Cell Layer Morphogenesis Auditory Receptor Cell Development Lung-associated Mesenchyme Development Cell Surface Receptor Signaling Pathway Regulation Of Cell Fate Specification Regulation Of Water Loss Via Skin Regulation Of Neurogenesis Reflex Cell Morphogenesis Involved In Differentiation Behavioral Response To Pain Neuromuscular Synaptic Transmission Cell Differentiation Brain Development Regulation Of Hormone Biosynthetic Process Paraxial Mesoderm Development Middle Ear Morphogenesis	Response To Brefeldin A Determination Of Left/right Symmetry Determination Of Bilateral Symmetry T-helper 1 Cell Lineage Commitment Nerve Growth Factor Production Zygotic Determination Of Anterior/posterior Axis, Embryo Nerve Growth Factor Processing Positive Regulation Of Isotype Switching To IgE Isotypes Interleukin-4-mediated Signaling Pathway Smoothened Signaling Pathway Involved In Spinal Cord Motor Neuron Cell Fate Specification Smoothened Signaling Pathway Involved In Ventral Spinal Cord Interneuron Specification Negative Regulation Of Transcription From RNA Polymerase II Promoter Smoothened Signaling Pathway Involved In Ventral Spinal Cord Patterning Methylation-dependent Chromatin Silencing T-helper Cell Lineage Commitment Negative Regulation Of Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning T-helper 1 Cell Differentiation Negative Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process CD4-positive Or CD8-positive, Alpha-beta T Cell Lineage Commitment Cell Fate Commitment Negative Regulation Of Type 2 Immune Response Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Ventral Spinal Cord Interneuron Specification Negative Regulation Of RNA Biosynthetic Process Mammary Gland Epithelial Cell Proliferation Embryo Development Cellular Response To Reactive Nitrogen Species Spinal Cord Motor Neuron Cell Fate Specification Positive Regulation Of Isotype Switching T Cell Lineage Commitment Ventral Spinal Cord Interneuron Fate Commitment Response To Organic Substance Anterior/posterior Axis Specification, Embryo Ventral Spinal Cord Interneuron Differentiation Positive T Cell Selection T-helper 1 Type Immune Response Cytoplasmic Sequestering Of Transcription Factor T-helper Cell Differentiation Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process
Tagcloud ?		absent astrocytic cadherin candidate cdh11 convertase endocytosis functionally glioblastoma glioblastomas glioma gliomas immunoreactivity infiltrating infiltration infiltrative invasion kexin microdissected ontology proprotein rich sh3 sh3gl3 subtilisin tumour validate validated zone	advances attached ca2 cab45 calu calumenin carboxylase chaperone concern crec cytosol ef encoded epoxide erc localized participation parts pathophysiological rcn1 rcn2 reductase reticulocalbin ryanodine sarcoplasmic sdf4 secretory splicing transporting
Tagcloud (Difference) ?		absent astrocytic cadherin candidate cdh11 convertase endocytosis functionally glioblastoma glioblastomas glioma gliomas immunoreactivity infiltrating infiltration infiltrative invasion kexin microdissected ontology proprotein rich sh3 sh3gl3 subtilisin tumour validate validated zone	advances attached ca2 cab45 calu calumenin carboxylase chaperone concern crec cytosol ef encoded epoxide erc localized participation parts pathophysiological rcn1 rcn2 reductase reticulocalbin ryanodine sarcoplasmic sdf4 secretory splicing transporting
Tagcloud (Intersection) ?