PCSK6

Description		proprotein convertase subtilisin/kexin type 6
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Golgi Lumen Plasma Membrane Cell Surface Endomembrane System Membrane Extracellular Matrix
	Molecular Function	Endopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Heparin Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Nerve Growth Factor Binding
	Biological Process	Proteolysis Zygotic Determination Of Anterior/posterior Axis, Embryo Determination Of Left/right Symmetry Glycoprotein Metabolic Process Protein Processing Peptide Hormone Processing Regulation Of BMP Signaling Pathway Nerve Growth Factor Production Secretion By Cell Plasma Lipoprotein Particle Remodeling
Pathways		Signaling by NODAL NGF processing Formation of the cornified envelope Assembly of active LPL and LIPC lipase complexes Regulation of CDH1 posttranslational processing and trafficking to plasma membrane
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Cytokine levels ( 31679650) Cytokine network levels (multivariate analysis) ( 31679650) Handedness in dyslexia ( 21051773) Height ( 31562340) Inflammatory biomarkers (multivariate analysis) ( 33110245) Platelet-derived growth factor BB levels ( 27989323) Red blood cell count ( 32888494) Relative hand skill in reading disability ( 24068947) Severe coronary stenosis (young age of onset interaction) ( 33766035) Triglyceride levels ( 32203549) Triglycerides ( 30275531) Tuberculosis ( 30713548) Type 2 diabetes ( 30470734)
Novel Interacting Genes		6 novel interacting genes: ALPL FN3K IGF1R IL16 SNRPA1 SYNM
Interacting Genes		7 interacting genes: CACNA1A DYRK1A FLG PCSK5 PMCH RCN3 ZNF441
Entrez ID		5046
HPRD ID		01329
Ensembl ID		ENSG00000140479
Uniprot IDs		A2RQD9 H7BXT3 P29122 Q59H04
PDB IDs
Enriched GO Terms of Interacting Partners?		Phosphoethanolamine Phosphatase Activity Response To Vitamin B6 Futile Creatine Cycle Phosphoamidase Activity Extracellular Membrane-bounded Organelle Response To Amyloid-beta Cellular Response To Amyloid-beta Peptidyl-tyrosine Phosphorylation Histone H3T45 Kinase Activity Type 1 Melanin-concentrating Hormone Receptor Binding Negative Regulation Of Synaptic Transmission, Dopaminergic Melanin-concentrating Hormone Activity Neurofilament Cytoskeleton Fast-twitch Skeletal Muscle Fiber Contraction Protein-fructosamine 3-kinase Activity Fructosamine Metabolic Process Protein Deglycation Protein-ribulosamine 3-kinase Activity Fructoselysine Metabolic Process
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