KDM5B

Description		lysine demethylase 5B
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytosol
	Molecular Function	Nucleic Acid Binding DNA Binding Transcription Corepressor Activity Protein Binding Zinc Ion Binding Oxidoreductase Activity Histone Demethylase Activity Histone H3K4 Demethylase Activity Histone H3K4me/H3K4me2/H3K4me3 Demethylase Activity Histone Binding Metal Ion Binding Dioxygenase Activity Sequence-specific Double-stranded DNA Binding
	Biological Process	Chromatin Organization Chromatin Remodeling Regulation Of DNA-templated Transcription Single Fertilization Post-embryonic Development Positive Regulation Of Gene Expression Positive Regulation Of Mammary Gland Epithelial Cell Proliferation Cellular Response To Fibroblast Growth Factor Stimulus Negative Regulation Of DNA-templated Transcription Rhythmic Process Branching Involved In Mammary Gland Duct Morphogenesis Mammary Duct Terminal End Bud Growth Response To Fungicide Uterus Morphogenesis Lens Fiber Cell Differentiation Cellular Response To Leukemia Inhibitory Factor Regulation Of Estradiol Secretion
Pathways		HDMs demethylate histones TFAP2 (AP-2) family regulates transcription of cell cycle factors Chromatin modifications during the maternal to zygotic transition (MZT)
Drugs
Diseases
GWAS
Interacting Genes		6 interacting genes: FOXG1 KDM1A MBD3 NRIP1 PAX9 RB1
Entrez ID		10765
HPRD ID		09251
Ensembl ID		ENSG00000117139
Uniprot IDs		A0A3B3IS40 A0A3B3ITA8 Q9UGL1
PDB IDs		2MA5 2MNY 2MNZ 5A1F 5A3N 5A3P 5A3T 5A3W 5FPL 5FPU 5FUN 5FUP 5FV3 5FY4 5FY5 5FY9 5FYB 5FYS 5FYT 5FYU 5FYV 5FYY 5FYZ 5FZ0 5FZ1 5FZ3 5FZ4 5FZ6 5FZ7 5FZ8 5FZ9 5FZA 5FZB 5FZC 5FZD 5FZE 5FZF 5FZG 5FZH 5FZI 5FZK 5FZL 5FZM 5LW9 5LWB 6EIN 6EIU 6EIY 6EJ0 6EJ1 6EK6 6H4Z 6H50 6H51 6H52 6RBI
Enriched GO Terms of Interacting Partners?		Chromatin Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Cell Morphogenesis Involved In Neuron Differentiation Regulation Of DNA-templated Transcription Positive Regulation Of Neuroblast Proliferation Regulation Of RNA Biosynthetic Process Transcription Corepressor Activity Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Neuron Maturation Regulation Of RNA Metabolic Process Positive Regulation Of RNA Metabolic Process Epigenetic Regulation Of Gene Expression Regulation Of Neuroblast Proliferation Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Neural Precursor Cell Proliferation Nucleoplasm Regulation Of Neurogenesis Positive Regulation Of Cell Development Regulation Of Nervous System Development Regulation Of Developmental Process Cerebral Cortex Development Ovarian Follicle Rupture Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression Regulation Of Neural Precursor Cell Proliferation Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Regulation Of Primary Metabolic Process Response To Estradiol Telomeric Repeat-containing RNA Binding FAD-dependent H3K4me/H3K4me3 Demethylase Activity Regulation Of Cell Differentiation Pyramidal Neuron Migration To Cerebral Cortex Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Chromatin Remodeling Heterochromatin Formation Chromatin Lock Complex
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