KDM5B

Gene Name		lysine (K)-specific demethylase 5B
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Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Corepressor Activity Protein Binding Zinc Ion Binding Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, 2-oxoglutarate As One Donor, And Incorporation Of One Atom Each Of Oxygen Into Both Donors Histone Demethylase Activity (H3-trimethyl-K4 Specific) Histone Demethylase Activity (H3-dimethyl-K4 Specific)
	Biological Process	Chromatin Organization Transcription, DNA-templated Histone H3-K4 Demethylation Histone H3-K4 Demethylation, Trimethyl-H3-K4-specific Negative Regulation Of Transcription, DNA-templated Rhythmic Process Oxidation-reduction Process
Pathways		Chromatin modifying enzymes Chromatin organization HDMs demethylate histones
Drugs
Diseases
GWAS
Protein-protein Interactions		5 interactors: FOXG1 KDM1A MBD3 PAX9 RB1
Entrez ID		10765
HPRD ID		09251
Ensembl ID		ENSG00000117139
Uniprot IDs		Q9UFD3 Q9UGL1
PDB IDs		2MA5
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process RNA Metabolic Process Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Myeloid Cell Differentiation Chromatin Modification Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Primitive Erythrocyte Differentiation Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of RNA Metabolic Process Chromatin Organization Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Multicellular Organismal Development Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Head Development Regulation Of Gene Expression Anatomical Structure Development Negative Regulation Of Transcription From RNA Polymerase II Promoter During Mitosis Sister Chromatid Biorientation Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Myeloid Cell Differentiation Chromatin Remodeling Regulation Of Centromere Complex Assembly Negative Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Developmental Process Nitrogen Compound Metabolic Process Regulation Of Chromosome Organization Chromosome Organization Positive Regulation Of Transcription From RNA Polymerase II Promoter Maintenance Of Mitotic Sister Chromatid Cohesion Regulation Of Cohesin Localization To Chromatin Attachment Of Mitotic Spindle Microtubules To Kinetochore Myeloid Cell Differentiation Organ Development Methylation-dependent Chromatin Silencing
Tagcloud ?		accordingly balb bivalent demethylation e13 e15 e17 embryos epigenetic ezh2 fate germ h3k27me3 h3k4me3 immunofluorescence jmjd3 lysine marks methylation molar organ p0 p3 qpcr set7 spatiotemporal tooth transferases trimethylation