KDM5B and PAX9

Number of citations of the paper that reports this interaction (PMID 12657635)
24

Data Source:
BioGRID (affinity chromatography technology)
HPRD (two hybrid, in vivo)

		KDM5B	PAX9
Gene Name		lysine (K)-specific demethylase 5B	paired box 9
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm	Nucleus
	Molecular Function	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Corepressor Activity Protein Binding Zinc Ion Binding Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, 2-oxoglutarate As One Donor, And Incorporation Of One Atom Each Of Oxygen Into Both Donors Histone Demethylase Activity (H3-trimethyl-K4 Specific) Histone Demethylase Activity (H3-dimethyl-K4 Specific)	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Protein Binding
	Biological Process	Chromatin Organization Transcription, DNA-templated Histone H3-K4 Demethylation Histone H3-K4 Demethylation, Trimethyl-H3-K4-specific Negative Regulation Of Transcription, DNA-templated Rhythmic Process Oxidation-reduction Process	Transcription, DNA-templated Endoderm Development Odontogenesis Regulation Of Odontogenesis Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Face Morphogenesis Cellular Response To Growth Factor Stimulus
Pathways		Chromatin modifying enzymes Chromatin organization HDMs demethylate histones
Drugs
Diseases
GWAS			Breast cancer ( 23535729)
Protein-Protein Interactions		5 interactors: FOXG1 KDM1A MBD3 PAX9 RB1	11 interactors: FUBP3 GTF2A1L KDM5B MSX1 NR0B2 SSX4 TLE1 TLE2 TRIP4 ZNF440 ZNF580
Entrez ID		10765	5083
HPRD ID		09251	01336
Ensembl ID		ENSG00000117139	ENSG00000198807
Uniprot IDs		Q9UFD3 Q9UGL1	P55771 Q2L4T1
PDB IDs		2MA5
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process RNA Metabolic Process Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Myeloid Cell Differentiation Chromatin Modification Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Primitive Erythrocyte Differentiation Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of RNA Metabolic Process Chromatin Organization Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Multicellular Organismal Development Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Head Development Regulation Of Gene Expression Anatomical Structure Development Negative Regulation Of Transcription From RNA Polymerase II Promoter During Mitosis Sister Chromatid Biorientation Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Myeloid Cell Differentiation Chromatin Remodeling Regulation Of Centromere Complex Assembly Negative Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Developmental Process Nitrogen Compound Metabolic Process Regulation Of Chromosome Organization Chromosome Organization Positive Regulation Of Transcription From RNA Polymerase II Promoter Maintenance Of Mitotic Sister Chromatid Cohesion Regulation Of Cohesin Localization To Chromatin Attachment Of Mitotic Spindle Microtubules To Kinetochore Myeloid Cell Differentiation Organ Development Methylation-dependent Chromatin Silencing	Transcription, DNA-templated RNA Biosynthetic Process RNA Metabolic Process Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Transcription From RNA Polymerase II Promoter Regulation Of Metabolic Process Positive Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cellular Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Histone H3-K4 Demethylation, Trimethyl-H3-K4-specific Regulation Of Cellular Process Positive Regulation Of Mesenchymal Cell Apoptotic Process Embryonic Nail Plate Morphogenesis Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Activation Of Meiosis Notch Signaling Pathway Positive Regulation Of Metabolic Process BMP Signaling Pathway Involved In Heart Development Metabolic Process Transcription Initiation From RNA Polymerase II Promoter Histone H3-K4 Demethylation Negative Regulation Of Wnt Signaling Pathway Cellular Response To Nicotine Nail Development DNA-templated Transcription, Initiation Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Wnt Signaling Pathway Negative Regulation Of Anoikis Regulation Of Transcription From RNA Polymerase II Promoter Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation
Tagcloud ?		accordingly balb bivalent demethylation e13 e15 e17 embryos epigenetic ezh2 fate germ h3k27me3 h3k4me3 immunofluorescence jmjd3 lysine marks methylation molar organ p0 p3 qpcr set7 spatiotemporal tooth transferases trimethylation	agenesis c2c12 causative clarify convenient electrophoretic hard homeodomain hypodontia illustrates impair l205r lesser leu205 leu205arg mesenchymal msx1 mutational myod nonsyndromic oligodontia oligonucleotide pivotal sampled substitutions t174i thr174 thr174ile tooth
Tagcloud (Difference) ?		accordingly balb bivalent demethylation e13 e15 e17 embryos epigenetic ezh2 fate germ h3k27me3 h3k4me3 immunofluorescence jmjd3 lysine marks methylation molar organ p0 p3 qpcr set7 spatiotemporal transferases trimethylation	agenesis c2c12 causative clarify convenient electrophoretic hard homeodomain hypodontia illustrates impair l205r lesser leu205 leu205arg mesenchymal msx1 mutational myod nonsyndromic oligodontia oligonucleotide pivotal sampled substitutions t174i thr174 thr174ile
Tagcloud (Intersection) ?		tooth