KDM5B and PAX9

Number of citations of the paper that reports this interaction (PubMedID 17373667)
0

Data Source:
BioGRID (affinity chromatography technology)
HPRD (two hybrid, in vivo)

		KDM5B	PAX9
Description		lysine demethylase 5B	paired box 9
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytosol	Chromatin Nucleus Nucleoplasm Nucleolus
	Molecular Function	Nucleic Acid Binding DNA Binding Transcription Corepressor Activity Protein Binding Zinc Ion Binding Oxidoreductase Activity Histone Demethylase Activity Histone H3K4 Demethylase Activity Histone H3K4me/H3K4me2/H3K4me3 Demethylase Activity Histone Binding Metal Ion Binding Dioxygenase Activity Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Chromatin Organization Chromatin Remodeling Regulation Of DNA-templated Transcription Single Fertilization Post-embryonic Development Positive Regulation Of Gene Expression Positive Regulation Of Mammary Gland Epithelial Cell Proliferation Cellular Response To Fibroblast Growth Factor Stimulus Negative Regulation Of DNA-templated Transcription Rhythmic Process Branching Involved In Mammary Gland Duct Morphogenesis Mammary Duct Terminal End Bud Growth Response To Fungicide Uterus Morphogenesis Lens Fiber Cell Differentiation Cellular Response To Leukemia Inhibitory Factor Regulation Of Estradiol Secretion	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Endoderm Development Odontogenesis Regulation Of Odontogenesis Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Face Morphogenesis Cellular Response To Growth Factor Stimulus
Pathways		HDMs demethylate histones TFAP2 (AP-2) family regulates transcription of cell cycle factors Chromatin modifications during the maternal to zygotic transition (MZT)
Drugs
Diseases			Tooth agenesis; Hypodontia
GWAS			Breast cancer ( 23535729 29059683) Height ( 28552196) Lobe attachment (rater scored) ( 29198719) Lobe attachment (rater-scored or self-reported) ( 29198719) Nonsyndromic cleft palate ( 31609978) Prostate cancer ( 29892016)
Interacting Genes		6 interacting genes: FOXG1 KDM1A MBD3 NRIP1 PAX9 RB1	25 interacting genes: EYA2 FUBP3 GTF2A1L KDM5B KLF4 KRTAP13-3 LMO2 MSX1 MYLIP NR0B2 PFDN5 PLAGL2 SFN SLAIN1 SSX4 TEPSIN TLE1 TLE2 TRIP13 TRIP4 VPS37C WWOX ZNF343 ZNF440 ZNF580
Entrez ID		10765	5083
HPRD ID		09251	01336
Ensembl ID		ENSG00000117139	ENSG00000198807
Uniprot IDs		A0A3B3IS40 A0A3B3ITA8 Q9UGL1	P55771 Q2L4T1
PDB IDs		2MA5 2MNY 2MNZ 5A1F 5A3N 5A3P 5A3T 5A3W 5FPL 5FPU 5FUN 5FUP 5FV3 5FY4 5FY5 5FY9 5FYB 5FYS 5FYT 5FYU 5FYV 5FYY 5FYZ 5FZ0 5FZ1 5FZ3 5FZ4 5FZ6 5FZ7 5FZ8 5FZ9 5FZA 5FZB 5FZC 5FZD 5FZE 5FZF 5FZG 5FZH 5FZI 5FZK 5FZL 5FZM 5LW9 5LWB 6EIN 6EIU 6EIY 6EJ0 6EJ1 6EK6 6H4Z 6H50 6H51 6H52 6RBI
Enriched GO Terms of Interacting Partners?		Chromatin Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Cell Morphogenesis Involved In Neuron Differentiation Regulation Of DNA-templated Transcription Positive Regulation Of Neuroblast Proliferation Regulation Of RNA Biosynthetic Process Transcription Corepressor Activity Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Neuron Maturation Regulation Of RNA Metabolic Process Positive Regulation Of RNA Metabolic Process Epigenetic Regulation Of Gene Expression Regulation Of Neuroblast Proliferation Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Neural Precursor Cell Proliferation Nucleoplasm Regulation Of Neurogenesis Positive Regulation Of Cell Development Regulation Of Nervous System Development Regulation Of Developmental Process Cerebral Cortex Development Ovarian Follicle Rupture Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression Regulation Of Neural Precursor Cell Proliferation Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Regulation Of Primary Metabolic Process Response To Estradiol Telomeric Repeat-containing RNA Binding FAD-dependent H3K4me/H3K4me3 Demethylase Activity Regulation Of Cell Differentiation Pyramidal Neuron Migration To Cerebral Cortex Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Chromatin Remodeling Heterochromatin Formation Chromatin Lock Complex	Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Transcription Corepressor Activity Nucleus Transcription Regulator Complex Positive Regulation Of Macromolecule Metabolic Process Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of RNA Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Apoptotic Signaling Pathway Negative Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Wnt Signaling Pathway Transcription Coactivator Activity Transcription By RNA Polymerase II Animal Organ Morphogenesis Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Nucleobase-containing Compound Metabolic Process Establishment Of Skin Barrier Negative Regulation Of Odontoblast Differentiation Positive Regulation Of Apoptotic Signaling Pathway Sequence-specific Double-stranded DNA Binding Regulation Of Meiotic Nuclear Division Regulation Of Wnt Signaling Pathway RNA Polymerase III Assembly RNA Polymerase I Assembly Negative Regulation Of Canonical Wnt Signaling Pathway RNA Polymerase II Sequence-specific DNA-binding Transcription Factor Recruiting Activity Negative Regulation Of Leukocyte Adhesion To Arterial Endothelial Cell Coated Vesicle Membrane Skin Epidermis Development Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Extrinsic Apoptotic Signaling Pathway Transcription Coregulator Binding
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