PLN and ATP2A2

Number of citations of the paper that reports this interaction (PubMedID 11526231)
29

Data Source:
HPRD (in vitro, in vivo)

		PLN	ATP2A2
Description		phospholamban	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2
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GO Annotations	Cellular Component	Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Sarcoplasmic Reticulum Mitochondrial Membrane Vesicle Protein-containing Complex Sarcoplasmic Reticulum Membrane Perinuclear Region Of Cytoplasm Calcium Ion-transporting ATPase Complex Phospholamban Complex	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Intercalated Disc Longitudinal Sarcoplasmic Reticulum Membrane Sarcoplasmic Reticulum Platelet Dense Tubular Network Membrane Sarcoplasmic Reticulum Membrane Calcium Ion-transporting ATPase Complex Ribbon Synapse
	Molecular Function	Enzyme Inhibitor Activity Protein Binding ATPase Inhibitor Activity Identical Protein Binding Protein Homodimerization Activity Transmembrane Transporter Binding ATPase Binding Transporter Inhibitor Activity	Nucleotide Binding Calcium Channel Regulator Activity P-type Calcium Transporter Activity Calcium Ion Binding Protein Binding ATP Binding ATP Hydrolysis Activity Enzyme Binding Transmembrane Transporter Binding S100 Protein Binding Metal Ion Binding P-type Calcium Transporter Activity Involved In Regulation Of Cardiac Muscle Cell Membrane Potential LncRNA Binding
	Biological Process	Acrosome Assembly Regulation Of The Force Of Heart Contraction Calcium Ion Transport Intracellular Calcium Ion Homeostasis Notch Signaling Pathway Spermatogenesis Blood Circulation Regulation Of Heart Contraction Visual Learning Response To Zinc Ion Negative Regulation Of Heart Rate Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Response To Insulin Response To Testosterone Locomotor Rhythm Negative Regulation Of Heart Contraction Muscle Cell Cellular Homeostasis Cardiac Muscle Tissue Development Circadian Sleep/wake Cycle, Sleep Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Calcium Ion Transport Negative Regulation Of Calcium Ion Transport Relaxation Of Cardiac Muscle Regulation Of Cardiac Muscle Cell Contraction Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Involved In Heart Process Regulation Of Cardiac Muscle Cell Membrane Potential Regulation Of The Force Of Heart Contraction By Cardiac Conduction Regulation Of Calcium Ion Import Negative Regulation Of Calcium Ion Import Regulation Of Relaxation Of Muscle Regulation Of ATPase-coupled Calcium Transmembrane Transporter Activity Negative Regulation Of ATPase-coupled Calcium Transmembrane Transporter Activity Regulation Of Relaxation Of Cardiac Muscle Negative Regulation Of Calcium Ion Import Into Sarcoplasmic Reticulum	Autophagosome Assembly Regulation Of The Force Of Heart Contraction Muscle System Process Monoatomic Ion Transport Calcium Ion Transport Intracellular Calcium Ion Homeostasis Regulation Of Muscle Contraction ER-nucleus Signaling Pathway Cell Adhesion Epidermis Development Positive Regulation Of Heart Rate Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Transition Between Fast And Slow Fiber Cardiac Muscle Hypertrophy In Response To Stress Autophagosome Membrane Docking Endoplasmic Reticulum Calcium Ion Homeostasis Positive Regulation Of Endoplasmic Reticulum Calcium Ion Concentration T-tubule Organization Monoatomic Ion Transmembrane Transport Cellular Response To Oxidative Stress Response To Endoplasmic Reticulum Stress Negative Regulation Of Heart Contraction Relaxation Of Cardiac Muscle Neuron Cellular Homeostasis Sarcoplasmic Reticulum Calcium Ion Transport Calcium Ion Transmembrane Transport Regulation Of Cardiac Muscle Cell Membrane Potential Regulation Of Cardiac Muscle Cell Action Potential Involved In Regulation Of Contraction Organelle Localization By Membrane Tethering Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter Calcium Ion Transport From Cytosol To Endoplasmic Reticulum Regulation Of Cardiac Conduction Calcium Ion Import Into Sarcoplasmic Reticulum Mitochondrion-endoplasmic Reticulum Membrane Tethering
Pathways		Ion homeostasis Ion transport by P-type ATPases	Pre-NOTCH Processing in Golgi Reduction of cytosolic Ca++ levels Ion homeostasis Ion transport by P-type ATPases
Drugs			Ritodrine Desflurane Sevoflurane Istaroxime
Diseases			Acrokeratosis verruciformis Darier disease; Dyskeratosis follicularis
GWAS		Atrial fibrillation ( 28416818 30061737) Cardiac structure and function ( 19584346) Hypertrophic cardiomyopathy ( 33495597) Hypertrophic cardiomyopathy (sarcomere negative) ( 33495597) QRS complex (Sokolow-Lyon) ( 27659466) QRS duration ( 27577874 27659466) QT interval ( 19305408 19305409 19587794 23166209 24952745 29874175) Resting heart rate ( 27798624)	Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Glucose homeostasis traits ( 25524916) Protein quantitative trait loci ( 18464913) QT interval ( 24952745 29874175) Schizophrenia ( 25056061 28991256 29483656 30285260) Waist circumference ( 28552196)
Interacting Genes		68 interacting genes: AQP6 ARL13B ARLN ASGR2 ATP2A1 ATP2A2 ATP6V0E1 BCL2L13 BIK CD53 CLDN7 CLEC2D CPLX4 CREB3 CREB3L1 DMPK DVL3 EDA ELN ELOVL4 ERGIC3 FAM209A FKBP8 FNDC9 GJA8 GPR152 GPR37L1 GPX8 HIBADH HSD17B13 KIR2DL3 LDLRAD1 LSMEM2 MFF MGST2 MGST3 MS4A7 MTIF3 MUC1 PLPPR1 PPP1R3A PRKACA RTN3 S100A1 SAR1A SDC3 SIT1 SLC14A2 SLC30A8 SLC34A2 SLC35H1 SLC39A2 SLC61A1 SLN SPACA1 SPAG4 STX1A STX2 TMEM106C TMEM179B TMEM205 TMEM31 TMEM45A TMEM45B TMEM52B TMEM79 TMEM86B TMPRSS2	20 interacting genes: ARLN BCL2 CAMK2A CCR4 CEBPA CHRM5 ELN F2RL1 FILNC1 HGS IRS1 IRS2 MDM2 PLN S100A1 SPP1 SRI TNFAIP3 TRIM14 TTC3
Entrez ID		5350	488
HPRD ID		01395	00161
Ensembl ID		ENSG00000198523	ENSG00000174437
Uniprot IDs		P26678 Q5R352	A0A0S2Z3L2 P16615
PDB IDs		1PLP 1ZLL 2HYN 6Y40 7E0Z 7E11 7E12	5ZTF 6JJU 6LLE 6LLY 6LN5 6LN6 6LN7 6LN8 6LN9 7BT2 7E7S 7W7T 7W7U 7W7V 7W7W
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane Protein Binding Sarcoplasmic Reticulum Positive Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Sarcoplasmic Reticulum Membrane Endoplasmic Reticulum Sarcoplasmic Reticulum Calcium Ion Transport Calcium Ion Import Into Sarcoplasmic Reticulum Glutathione Peroxidase Activity Leukotriene-C4 Synthase Activity Regulation Of Cardiac Conduction Regulation Of ATPase-coupled Calcium Transmembrane Transporter Activity	Negative Regulation Of Multicellular Organismal Process Response To Hormone Protease Binding Positive Regulation Of Transport Regulation Of Secretion Regulation Of Secretion By Cell Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Regulation Of Transport Regulation Of Hormone Secretion Regulation Of Biological Quality Signal Transduction Response To Lipid Positive Regulation Of Fatty Acid Beta-oxidation Regulation Of Insulin Secretion Regulation Of System Process Negative Regulation Of B Cell Apoptotic Process Regulation Of Protein Localization Regulation Of Multicellular Organismal Process Response To Vitamin Regulation Of Peptide Hormone Secretion Regulation Of Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Fatty Acid Oxidation Regulation Of Heart Contraction Sarcoplasmic Reticulum Negative Regulation Of Heart Rate Response To Steroid Hormone Regulation Of Calcium Ion Transport Negative Regulation Of Transport Protein Domain Specific Binding Regulation Of Fatty Acid Beta-oxidation Phosphatidylinositol 3-kinase Binding Positive Regulation Of Glycogen Biosynthetic Process Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Regulation Of Relaxation Of Muscle Regulation Of Protein Transport Tolerance Induction Calcium Ion Transport Response To Hydrogen Peroxide Regulation Of B Cell Apoptotic Process Regulation Of Blood Circulation Ubiquitin Binding Regulation Of Heart Rate Negative Regulation Of Heart Contraction Regulation Of Protein Secretion Insulin Receptor Binding Negative Regulation Of Blood Circulation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Negative Regulation Of Transmembrane Transport Protein Polyubiquitination Regulation Of Cellular Localization
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