PLN and ELOVL4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PLN	ELOVL4
Description		phospholamban	ELOVL fatty acid elongase 4
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Sarcoplasmic Reticulum Mitochondrial Membrane Vesicle Protein-containing Complex Sarcoplasmic Reticulum Membrane Perinuclear Region Of Cytoplasm Calcium Ion-transporting ATPase Complex Phospholamban Complex	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Enzyme Inhibitor Activity Protein Binding ATPase Inhibitor Activity Identical Protein Binding Protein Homodimerization Activity Transmembrane Transporter Binding ATPase Binding Transporter Inhibitor Activity	Protein Binding G Protein-coupled Photoreceptor Activity Fatty Acid Elongase Activity Transferase Activity
	Biological Process	Acrosome Assembly Regulation Of The Force Of Heart Contraction Calcium Ion Transport Intracellular Calcium Ion Homeostasis Notch Signaling Pathway Spermatogenesis Blood Circulation Regulation Of Heart Contraction Visual Learning Response To Zinc Ion Negative Regulation Of Heart Rate Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Response To Insulin Response To Testosterone Locomotor Rhythm Negative Regulation Of Heart Contraction Muscle Cell Cellular Homeostasis Cardiac Muscle Tissue Development Circadian Sleep/wake Cycle, Sleep Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Calcium Ion Transport Negative Regulation Of Calcium Ion Transport Relaxation Of Cardiac Muscle Regulation Of Cardiac Muscle Cell Contraction Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Involved In Heart Process Regulation Of Cardiac Muscle Cell Membrane Potential Regulation Of The Force Of Heart Contraction By Cardiac Conduction Regulation Of Calcium Ion Import Negative Regulation Of Calcium Ion Import Regulation Of Relaxation Of Muscle Regulation Of ATPase-coupled Calcium Transmembrane Transporter Activity Negative Regulation Of ATPase-coupled Calcium Transmembrane Transporter Activity Regulation Of Relaxation Of Cardiac Muscle Negative Regulation Of Calcium Ion Import Into Sarcoplasmic Reticulum	Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Unsaturated Fatty Acid Biosynthetic Process Detection Of Visible Light Fatty Acid Elongation, Saturated Fatty Acid Sphingolipid Biosynthetic Process Fatty Acid Elongation Fatty Acid Elongation, Monounsaturated Fatty Acid Fatty Acid Elongation, Polyunsaturated Fatty Acid Long-chain Fatty-acyl-CoA Biosynthetic Process Very Long-chain Fatty Acid Biosynthetic Process
Pathways		Ion homeostasis Ion transport by P-type ATPases	Synthesis of very long-chain fatty acyl-CoAs
Drugs			Omega-3-carboxylic acids
Diseases			Stargardt disease (STGD); Fundus flavimaculatus
GWAS		Atrial fibrillation ( 28416818 30061737) Cardiac structure and function ( 19584346) Hypertrophic cardiomyopathy ( 33495597) Hypertrophic cardiomyopathy (sarcomere negative) ( 33495597) QRS complex (Sokolow-Lyon) ( 27659466) QRS duration ( 27577874 27659466) QT interval ( 19305408 19305409 19587794 23166209 24952745 29874175) Resting heart rate ( 27798624)	Aging ( 22773346) Body mass index ( 23669352) Chronic obstructive pulmonary disease ( 28166215) Daytime sleep phenotypes ( 27126917) Hip circumference adjusted for BMI ( 34021172) Macular thickness ( 30535121) Partial epilepsies ( 20522523) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		68 interacting genes: AQP6 ARL13B ARLN ASGR2 ATP2A1 ATP2A2 ATP6V0E1 BCL2L13 BIK CD53 CLDN7 CLEC2D CPLX4 CREB3 CREB3L1 DMPK DVL3 EDA ELN ELOVL4 ERGIC3 FAM209A FKBP8 FNDC9 GJA8 GPR152 GPR37L1 GPX8 HIBADH HSD17B13 KIR2DL3 LDLRAD1 LSMEM2 MFF MGST2 MGST3 MS4A7 MTIF3 MUC1 PLPPR1 PPP1R3A PRKACA RTN3 S100A1 SAR1A SDC3 SIT1 SLC14A2 SLC30A8 SLC34A2 SLC35H1 SLC39A2 SLC61A1 SLN SPACA1 SPAG4 STX1A STX2 TMEM106C TMEM179B TMEM205 TMEM31 TMEM45A TMEM45B TMEM52B TMEM79 TMEM86B TMPRSS2	106 interacting genes: ADGRE2 ANKRD46 APOL2 APOL3 ARLN ATP13A1 BCL2L1 BET1 BIK BNIP1 BNIP3 BTN2A2 C1GALT1 CCDC167 CCL4L2 CD70 CDIPT CLCA4 CLDND2 CMTM3 CMTM5 CMTM7 COL4A5 CYB5R3 CYP4F2 EMC6 ERG28 FA2H FAM177A1 FAM3C FAXDC2 FDFT1 FKBP8 FXYD6 GIMAP1 GIMAP5 GOSR2 GPR37L1 GYPA HMOX1 HMOX2 HSD3B7 IER3IP1 INSIG2 ITGAM JAGN1 LEPROTL1 LHFPL5 LPAR3 LY6D MALL MMP14 NINJ2 ORMDL2 ORMDL3 PEX16 PKMYT1 PLLP PLN PLP1 PTPN1 RAB18 RTP2 SEC22A SEC22B SERF1A SERF1B SERP2 SFT2D2 SLC30A3 SLC30A8 SMCO4 SMIM1 SNORC STX3 STX8 SYNDIG1 TECR TF TMEM11 TMEM128 TMEM19 TMEM203 TMEM218 TMEM222 TMEM242 TMEM243 TMEM254 TMEM42 TMEM44 TRARG1 TREX1 TSNARE1 UBE2J1 UBIAD1 UNC50 VAMP1 VAMP3 VAMP4 VAMP5 VAPB VMA12 YIF1A YIPF6 ZDHHC21 ZFPL1
Entrez ID		5350	6785
HPRD ID		01395	05697
Ensembl ID		ENSG00000198523	ENSG00000118402
Uniprot IDs		P26678 Q5R352	Q9GZR5
PDB IDs		1PLP 1ZLL 2HYN 6Y40 7E0Z 7E11 7E12
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane Protein Binding Sarcoplasmic Reticulum Positive Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Sarcoplasmic Reticulum Membrane Endoplasmic Reticulum Sarcoplasmic Reticulum Calcium Ion Transport Calcium Ion Import Into Sarcoplasmic Reticulum Glutathione Peroxidase Activity Leukotriene-C4 Synthase Activity Regulation Of Cardiac Conduction Regulation Of ATPase-coupled Calcium Transmembrane Transporter Activity	Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum SNAP Receptor Activity SNARE Complex Endomembrane System Membrane Fusion Organelle Fusion Organelle Membrane Fusion Vesicle-mediated Transport Golgi Vesicle Transport Establishment Of Protein Localization Vesicle Fusion Protein Binding Membrane Organization Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Protein Transport Vesicle Organization Cellular Localization Sterol Biosynthetic Process Establishment Of Protein Localization To Membrane Golgi Membrane Steroid Biosynthetic Process Mitochondrial Membrane Membrane Docking Structural Constituent Of Myelin Sheath Intracellular Transport Endoplasmic Reticulum Organization Heme Oxidation Heme Oxygenase (decyclizing) Activity Transport Vesicle SNARE Complex Assembly Lipid Biosynthetic Process Organelle Localization By Membrane Tethering Sterol Metabolic Process Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Golgi Apparatus Insulin Metabolic Process Inorganic Ion Homeostasis Intracellular Sphingolipid Homeostasis Negative Regulation Of Ceramide Biosynthetic Process Establishment Of Protein Localization To Plasma Membrane Establishment Of Localization In Cell Intracellular Protein Localization Intracellular Chemical Homeostasis Transferase Activity, Transferring Alkyl Or Aryl (other Than Methyl) Groups Menaquinone Metabolic Process Negative Regulation Of Sphingolipid Biosynthetic Process Vesicle Docking Steroid Metabolic Process
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