PLN

Gene Name		phospholamban
Image
Gene Ontology Annotations	Cellular Component	Mitochondrion Endoplasmic Reticulum Membrane Mitochondrial Membrane Vesicle Sarcoplasmic Reticulum Membrane Perinuclear Region Of Cytoplasm Calcium Ion-transporting ATPase Complex
	Molecular Function	Enzyme Inhibitor Activity Calcium Channel Regulator Activity Protein Binding ATPase Inhibitor Activity Identical Protein Binding ATPase Binding
	Biological Process	Regulation Of The Force Of Heart Contraction Calcium Ion Transport Blood Circulation Regulation Of Heart Contraction Response To Zinc Ion Negative Regulation Of Heart Rate Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Negative Regulation Of ATPase Activity Response To Insulin Response To Testosterone Negative Regulation Of Catalytic Activity Cardiac Muscle Tissue Development Protein Homooligomerization Cytosolic Calcium Ion Homeostasis Regulation Of Calcium Ion Transport Negative Regulation Of Calcium Ion Transport Relaxation Of Cardiac Muscle Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Cardiac Muscle Cell Contraction Adrenergic Receptor Signaling Pathway Involved In Heart Process Regulation Of Cardiac Muscle Cell Membrane Potential Regulation Of The Force Of Heart Contraction By Cardiac Conduction Negative Regulation Of Calcium Ion Import Negative Regulation Of Calcium Ion Transmembrane Transporter Activity Negative Regulation Of Calcium Ion Binding Regulation Of Calcium-transporting ATPase Activity Negative Regulation Of Calcium-transporting ATPase Activity Regulation Of Relaxation Of Cardiac Muscle Negative Regulation Of Calcium Ion Import Into Sarcoplasmic Reticulum
Pathways		Ion transport by P-type ATPases Ion channel transport
Drugs
Diseases
GWAS		Cardiac structure and function ( 19584346) QT interval ( 23166209 19305408 19305409 19587794) Ventricular conduction ( 21076409)
Protein-protein Interactions		11 interactors: ATP2A1 ATP2A2 DMPK DVL3 EDA LDLRAD1 PPP1R3A PRKACA S100A1 SLN TMEM79
Entrez ID		5350
HPRD ID		01395
Ensembl ID		ENSG00000198523
Uniprot IDs		P26678 Q5R352
PDB IDs		1K9N 1KCH 1PLN 1PLP 1PSL 1ZLL 2HYN
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Regulation Of Heart Contraction Regulation Of Calcium Ion Transmembrane Transport Regulation Of Calcium Ion Transmembrane Transporter Activity Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Regulation Of Striated Muscle Contraction Sarcoplasmic Reticulum Calcium Ion Transport Chemical Homeostasis Cellular Metal Ion Homeostasis Cellular Cation Homeostasis Cellular Ion Homeostasis Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Metal Ion Homeostasis Regulation Of Muscle Contraction Relaxation Of Muscle Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Cellular Chemical Homeostasis Ion Homeostasis Regulation Of Calcium Ion Transport Regulation Of Body Fluid Levels Regulation Of The Force Of Heart Contraction Calcium Ion Import Endoplasmic Reticulum Calcium Ion Homeostasis Homeostatic Process Cellular Homeostasis Epidermis Development Multicellular Organismal Water Homeostasis Calcium Ion Transport Water Homeostasis Nuclear Envelope Organization Calcium Ion Transport From Cytosol To Endoplasmic Reticulum Positive Regulation Of Dense Core Granule Biogenesis Calcium Ion Import Into Sarcoplasmic Reticulum Positive Regulation Of Fast-twitch Skeletal Muscle Fiber Contraction Regulation Of Heart Rate Regulation Of Cardiac Muscle Contraction Regulation Of Cation Channel Activity Intracellular Signal Transduction Programmed Cell Death Regulation Of Ion Transmembrane Transport Blood Coagulation Hemostasis Cell Death Death Calcium-mediated Signaling Hair Follicle Development Hair Cycle Process Epithelium Development
Tagcloud ?		augment axillary ccr7 cd45 clue conditioned cues deadly drained emerge fivefold infiltrated infiltrating intriguingly leukocyte leukocytes lymph mcf microenvironment nln nlns nodes plns secreted secretions skbr3 subsets tals tributaries