PLN and SLN

Number of citations of the paper that reports this interaction (PMID 12692302)
23

Data Source:
HPRD (in vivo)

		PLN	SLN
Gene Name		phospholamban	sarcolipin
Image
Gene Ontology Annotations	Cellular Component	Mitochondrion Endoplasmic Reticulum Membrane Mitochondrial Membrane Vesicle Sarcoplasmic Reticulum Membrane Perinuclear Region Of Cytoplasm Calcium Ion-transporting ATPase Complex	Integral Component Of Membrane Sarcoplasmic Reticulum Sarcoplasmic Reticulum Membrane
	Molecular Function	Enzyme Inhibitor Activity Calcium Channel Regulator Activity Protein Binding ATPase Inhibitor Activity Identical Protein Binding ATPase Binding	Enzyme Inhibitor Activity ATPase Binding
	Biological Process	Regulation Of The Force Of Heart Contraction Calcium Ion Transport Blood Circulation Regulation Of Heart Contraction Response To Zinc Ion Negative Regulation Of Heart Rate Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Negative Regulation Of ATPase Activity Response To Insulin Response To Testosterone Negative Regulation Of Catalytic Activity Cardiac Muscle Tissue Development Protein Homooligomerization Cytosolic Calcium Ion Homeostasis Regulation Of Calcium Ion Transport Negative Regulation Of Calcium Ion Transport Relaxation Of Cardiac Muscle Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Cardiac Muscle Cell Contraction Adrenergic Receptor Signaling Pathway Involved In Heart Process Regulation Of Cardiac Muscle Cell Membrane Potential Regulation Of The Force Of Heart Contraction By Cardiac Conduction Negative Regulation Of Calcium Ion Import Negative Regulation Of Calcium Ion Transmembrane Transporter Activity Negative Regulation Of Calcium Ion Binding Regulation Of Calcium-transporting ATPase Activity Negative Regulation Of Calcium-transporting ATPase Activity Regulation Of Relaxation Of Cardiac Muscle Negative Regulation Of Calcium Ion Import Into Sarcoplasmic Reticulum	Calcium Ion Transport Negative Regulation Of Catalytic Activity Negative Regulation Of Protein Complex Disassembly Regulation Of Calcium Ion Transport Sarcoplasmic Reticulum Calcium Ion Transport Negative Regulation Of Calcium Ion Import Negative Regulation Of Calcium Ion Transmembrane Transporter Activity Regulation Of Relaxation Of Muscle Negative Regulation Of Calcium Ion Binding Positive Regulation Of Protein Depolymerization Regulation Of Calcium-transporting ATPase Activity
Pathways		Ion transport by P-type ATPases Ion channel transport
Drugs
Diseases
GWAS		Cardiac structure and function ( 19584346) QT interval ( 23166209 19305408 19305409 19587794) Ventricular conduction ( 21076409)
Protein-Protein Interactions		11 interactors: ATP2A1 ATP2A2 DMPK DVL3 EDA LDLRAD1 PPP1R3A PRKACA S100A1 SLN TMEM79	5 interactors: ATP2A1 CCDC155 PLN SYNE4 TMEM79
Entrez ID		5350	6588
HPRD ID		01395	03729
Ensembl ID		ENSG00000198523	ENSG00000170290
Uniprot IDs		P26678 Q5R352	O00631
PDB IDs		1K9N 1KCH 1PLN 1PLP 1PSL 1ZLL 2HYN	1JDM
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Regulation Of Heart Contraction Regulation Of Calcium Ion Transmembrane Transport Regulation Of Calcium Ion Transmembrane Transporter Activity Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Regulation Of Striated Muscle Contraction Sarcoplasmic Reticulum Calcium Ion Transport Chemical Homeostasis Cellular Metal Ion Homeostasis Cellular Cation Homeostasis Cellular Ion Homeostasis Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Metal Ion Homeostasis Regulation Of Muscle Contraction Relaxation Of Muscle Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Cellular Chemical Homeostasis Ion Homeostasis Regulation Of Calcium Ion Transport Regulation Of Body Fluid Levels Regulation Of The Force Of Heart Contraction Calcium Ion Import Endoplasmic Reticulum Calcium Ion Homeostasis Homeostatic Process Cellular Homeostasis Epidermis Development Multicellular Organismal Water Homeostasis Calcium Ion Transport Water Homeostasis Nuclear Envelope Organization Calcium Ion Transport From Cytosol To Endoplasmic Reticulum Positive Regulation Of Dense Core Granule Biogenesis Calcium Ion Import Into Sarcoplasmic Reticulum Positive Regulation Of Fast-twitch Skeletal Muscle Fiber Contraction Regulation Of Heart Rate Regulation Of Cardiac Muscle Contraction Regulation Of Cation Channel Activity Intracellular Signal Transduction Programmed Cell Death Regulation Of Ion Transmembrane Transport Blood Coagulation Hemostasis Cell Death Death Calcium-mediated Signaling Hair Follicle Development Hair Cycle Process Epithelium Development	Relaxation Of Muscle Regulation Of Striated Muscle Contraction Chromosome Localization To Nuclear Envelope Involved In Synapsis Negative Regulation Of Calcium-transporting ATPase Activity Positive Regulation Of Fast-twitch Skeletal Muscle Fiber Contraction Negative Regulation Of Calcium Ion Import Into Sarcoplasmic Reticulum Relaxation Of Skeletal Muscle Negative Regulation Of Calcium Ion Binding Maintenance Of Mitochondrion Location Positive Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Regulation Of The Force Of Heart Contraction By Cardiac Conduction Regulation Of Muscle Contraction Chemical Homeostasis Cuticle Development Regulation Of Calcium-transporting ATPase Activity Adrenergic Receptor Signaling Pathway Involved In Heart Process Cornification G-protein Coupled Receptor Signaling Pathway Involved In Heart Process Establishment Of Epithelial Cell Apical/basal Polarity Negative Regulation Of Calcium Ion Import Muscle System Process Regulation Of Relaxation Of Cardiac Muscle Cellular Calcium Ion Homeostasis Establishment Of Apical/basal Cell Polarity Negative Regulation Of Striated Muscle Contraction Polarized Epithelial Cell Differentiation Calcium Ion Homeostasis Calcium Ion Transport Negative Regulation Of ATPase Activity Regulation Of Cardiac Muscle Cell Membrane Potential Regulation Of Relaxation Of Muscle Homeostatic Process Regulation Of Skeletal Muscle Contraction Negative Regulation Of Heart Rate Positive Regulation Of Mitochondrial Calcium Ion Concentration Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Establishment Of Monopolar Cell Polarity Positive Regulation Of Striated Muscle Contraction Relaxation Of Cardiac Muscle Cellular Metal Ion Homeostasis Organelle Localization Cellular Cation Homeostasis Adrenergic Receptor Signaling Pathway Tissue Development Cellular Ion Homeostasis Negative Regulation Of Calcium Ion Transmembrane Transporter Activity Mitochondrial Calcium Ion Homeostasis Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Establishment Of Skin Barrier Establishment Of Epithelial Cell Polarity
Tagcloud ?		augment axillary ccr7 cd45 clue conditioned cues deadly drained emerge fivefold infiltrated infiltrating intriguingly leukocyte leukocytes lymph mcf microenvironment nln nlns nodes plns secreted secretions skbr3 subsets tals tributaries	abr acoustic agno antioxidants brainstem centered cochlea cochleas counted edaravone entrapment exerted guinea hair hearing intratympanic khz nihl noise noticeable ohcs pigs prepare silvernitrate slns sound spl thresholds ultrasound
Tagcloud (Difference) ?		augment axillary ccr7 cd45 clue conditioned cues deadly drained emerge fivefold infiltrated infiltrating intriguingly leukocyte leukocytes lymph mcf microenvironment nln nlns nodes plns secreted secretions skbr3 subsets tals tributaries	abr acoustic agno antioxidants brainstem centered cochlea cochleas counted edaravone entrapment exerted guinea hair hearing intratympanic khz nihl noise noticeable ohcs pigs prepare silvernitrate slns sound spl thresholds ultrasound
Tagcloud (Intersection) ?