BTBD1 and TRIM5

Number of citations: 0 (PubMedID 12878161)
Data Source: HPRD (in vitro)

		BTBD1	TRIM5
Name		BTB domain containing 1	tripartite motif containing 5
Structure		No pdb structure
GO Annotations	Cellular Component	P-body Nucleoplasm Cytoplasm Cytosol Protein-containing Complex Cytoplasmic Ribonucleoprotein Granule	P-body Nucleus Cytoplasm Cytosol Omegasome
	Molecular Function	Protein Binding Identical Protein Binding Cullin Family Protein Binding	Transcription Coactivator Activity Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Protein Kinase Binding Protein-macromolecule Adaptor Activity Pattern Recognition Receptor Activity Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Muscle Organ Development Protein Ubiquitination Neurogenesis Cell Differentiation Regulation Of Protein Binding	Activation Of Innate Immune Response Immune System Process Autophagy Regulation Of Gene Expression Protein Ubiquitination Regulation Of Lipopolysaccharide-mediated Signaling Pathway Regulation Of Protein Localization Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of MAPK Cascade Suppression Of Viral Release By Host Innate Immune Response Positive Regulation Of DNA-templated Transcription Regulation Of Viral Entry Into Host Cell Host-mediated Suppression Of Symbiont Invasion Positive Regulation Of NF-kappaB Transcription Factor Activity Defense Response To Virus Protein K63-linked Ubiquitination Regulation Of Primary Metabolic Process
Pathways		Neddylation Antigen processing: Ubiquitination & Proteasome degradation	Interferon gamma signaling
GWAS		Chronic obstructive pulmonary disease ( 30804561 ) Estimated glomerular filtration rate ( 31152163 ) Kawasaki disease ( 21326860 )	Alanine aminotransferase levels ( 33547301 ) Apolipoprotein A1 levels ( 32203549 ) Apolipoprotein B levels ( 32203549 ) Aspartate aminotransferase levels ( 33547301 ) Coronary artery disease ( 29212778 33020668 ) DNA methylation (variation) ( 23725790 ) HDL cholesterol levels ( 32203549 ) LDL cholesterol levels ( 32203549 ) Liver enzyme levels (alanine transaminase) ( 33972514 ) Liver enzyme levels (alkaline phosphatase) ( 33972514 ) Low density lipoprotein cholesterol levels ( 32154731 ) Malaria ( 31844061 ) Mean platelet volume ( 32888494 27863252 ) Midgestational circulating levels of PBDEs (fetal genetic effect) ( 28235828 ) Myocardial infarction ( 33532862 ) Platelet count ( 32888494 29403010 ) Serum alkaline phosphatase levels ( 33339817 29403010 33547301 ) Severe COVID-19 infection with respiratory failure (analysis I) ( 32558485 )
Novel Interactors		1 novel interactors: TRAF7	None recorded
Interacting Genes		12 interacting genes: DSCAM DSCR9 LNX1 MPP3 MTNR1B PSMD5 RNF4 RSPH1 TOP1 TRIM5 TULP3 UBC	49 interacting genes: BTBD1 BTBD2 CFTR DSCR9 EHHADH EWSR1 ITSN1 LGALS8 LZTR1 MKRN3 MNAT1 MPP7 MTURN NTAQ1 OTUB2 OTUD6A PCBD1 PIAS1 PRKCG PSMC2 RUNX1 SGTA TNFAIP3 TRIM21 TRIM32 TRIM34 TRIM35 TRIM6 TSGA10IP UBASH3A UBB UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2H UBE2K UBE2N UBE2U UBE2V1 UBE2V2 UBE2W USP15 USP2 USP21 USP39 USP5 YES1
Entrez ID		53339	85363
HPRD ID		12251	07004
Ensembl ID		ENSG00000064726	ENSG00000132256
Uniprot IDs		Q9H0C5	A0A804HHS7 Q9C035
PDB IDs		Not available	2ECV 2YRG
GO Terms Enriched among Interactors		Ubiquitin Protein Ligase Activity Protein Modification By Small Protein Conjugation Ubiquitin-protein Transferase Activity Protein Ubiquitination Post-translational Protein Modification	Post-translational Protein Modification Protein Modification Process Protein Modification By Small Protein Conjugation Protein Ubiquitination Ubiquitin Conjugating Enzyme Activity Protein Polyubiquitination Protein Metabolic Process Proteolysis Protein K48-linked Ubiquitination Ubiquitin-protein Transferase Activity Cysteine-type Deubiquitinase Activity Protein Deubiquitination Proteolysis Involved In Protein Catabolic Process Macromolecule Metabolic Process Protein Modification By Small Protein Removal Modification-dependent Protein Catabolic Process UBC13-MMS2 Complex Regulation Of Post-translational Protein Modification Protein K63-linked Ubiquitination Ubiquitin Conjugating Enzyme Complex Cysteine-type Peptidase Activity Transferase Activity Macromolecule Catabolic Process Positive Regulation Of Protein Polyubiquitination Nucleus Positive Regulation Of Protein Metabolic Process Ubiquitin-dependent Protein Catabolic Process Ubiquitin Protein Ligase Activity Free Ubiquitin Chain Polymerization Regulation Of Protein Catabolic Process Regulation Of Proteolysis Positive Regulation Of Protein K63-linked Ubiquitination Regulation Of Protein Ubiquitination Regulation Of Protein Polyubiquitination Regulation Of Protein Modification Process Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Post-translational Protein Modification Regulation Of Protein Metabolic Process Protein K11-linked Deubiquitination Protein K11-linked Ubiquitination Proteasomal Protein Catabolic Process Regulation Of Protein K63-linked Ubiquitination Error-free Postreplication DNA Repair Positive Regulation Of Protein Modification Process Ubiquitin Binding Catabolic Process Positive Regulation Of Protein Ubiquitination Response To Virus Suppression Of Viral Release By Host Cytosol