BTBD1 and TRAF7

Data Source: HiPPIP (Novel)

		BTBD1	TRAF7
Name		BTB domain containing 1	TNF receptor associated factor 7
Structure		No pdb structure
GO Annotations	Cellular Component	P-body Nucleoplasm Cytoplasm Cytosol Protein-containing Complex Cytoplasmic Ribonucleoprotein Granule	Ubiquitin Ligase Complex Nucleus Cytoplasm Plasma Membrane Cytoplasmic Vesicle
	Molecular Function	Protein Binding Identical Protein Binding Cullin Family Protein Binding	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Muscle Organ Development Protein Ubiquitination Neurogenesis Cell Differentiation Regulation Of Protein Binding	Regulation Of Transcription By RNA Polymerase II Apoptotic Process Canonical NF-kappaB Signal Transduction Protein Ubiquitination Protein K29-linked Ubiquitination Positive Regulation Of MAPK Cascade Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of Protein Metabolic Process Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Apoptotic Signaling Pathway
Pathways		Neddylation Antigen processing: Ubiquitination & Proteasome degradation	Antigen processing: Ubiquitination & Proteasome degradation
GWAS		Chronic obstructive pulmonary disease ( 30804561 ) Estimated glomerular filtration rate ( 31152163 ) Kawasaki disease ( 21326860 )	Diastolic blood pressure ( 30578418 ) Height ( 28552196 ) Liver enzyme levels (alkaline phosphatase) ( 33972514 ) Pulse pressure ( 30578418 ) Systolic blood pressure ( 30578418 )
Novel Interactors		1 novel interactors: TRAF7	6 novel interactors: BTBD1 HAGHL HDGF NUDT16L1 PBXIP1 PPIC
Interacting Genes		12 interacting genes: DSCAM DSCR9 LNX1 MPP3 MTNR1B PSMD5 RNF4 RSPH1 TOP1 TRIM5 TULP3 UBC	11 interacting genes: CYLD MAP3K3 OGT RIPK4 TRAF6 UBE2D1 UBE2D2 UBE2D4 UBE2K UBE2L3 UBE2L6
Entrez ID		53339	84231
HPRD ID		12251	06977
Ensembl ID		ENSG00000064726	ENSG00000131653
Uniprot IDs		Q9H0C5	B3KQY7 Q6Q0C0
PDB IDs		Not available	8IMS
GO Terms Enriched among Interactors		Ubiquitin Protein Ligase Activity Protein Modification By Small Protein Conjugation Ubiquitin-protein Transferase Activity Protein Ubiquitination Post-translational Protein Modification	Ubiquitin Conjugating Enzyme Activity Ubiquitin-protein Transferase Activity Protein Polyubiquitination Post-translational Protein Modification Protein Modification Process Protein K48-linked Ubiquitination Protein Ubiquitination Protein Modification By Small Protein Conjugation Transferase Activity Proteolysis Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Metabolic Process Macromolecule Catabolic Process Proteolysis Involved In Protein Catabolic Process Regulation Of Protein Ubiquitination Macromolecule Metabolic Process Regulation Of Post-translational Protein Modification Nucleotide Binding Ubiquitin-ubiquitin Ligase Activity Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Positive Regulation Of Protein Ubiquitination Ubiquitin-like Protein Transferase Activity ATP Binding Catabolic Process Positive Regulation Of Post-translational Protein Modification Regulation Of Protein Modification Process Regulation Of Protein Localization To Synapse Regulation Of Receptor Localization To Synapse Regulation Of Necroptotic Process Positive Regulation Of Protein Modification Process Regulation Of Programmed Necrotic Cell Death Protein-containing Complex Regulation Of DNA-binding Transcription Factor Activity Protein K11-linked Ubiquitination Regulation Of P38MAPK Cascade Negative Regulation Of Interleukin-18-mediated Signaling Pathway Met1-linked Polyubiquitin Deubiquitinase Activity Positive Regulation Of Protein Metabolic Process Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Gene Expression Involved In Extracellular Matrix Organization Cytosol Positive Regulation Of Canonical NF-kappaB Signal Transduction Canonical NF-kappaB Signal Transduction TORC1 Signaling Ripoptosome Assembly Ripoptosome Assembly Involved In Necroptotic Process Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Protein Autoubiquitination