BTBD1 and PSMD5

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		BTBD1	PSMD5
Name		BTB domain containing 1	proteasome 26S subunit, non-ATPase 5
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	P-body Nucleoplasm Cytoplasm Cytosol Protein-containing Complex Cytoplasmic Ribonucleoprotein Granule	Proteasome Complex Cytosol Proteasome Regulatory Particle, Base Subcomplex Proteasome Accessory Complex
	Molecular Function	Protein Binding Identical Protein Binding Cullin Family Protein Binding	Protein Binding
	Biological Process	Muscle Organ Development Protein Ubiquitination Neurogenesis Cell Differentiation Regulation Of Protein Binding	Proteasome Assembly Proteasome Regulatory Particle Assembly
Pathways		Neddylation Antigen processing: Ubiquitination & Proteasome degradation	Proteasome assembly Proteasome assembly
GWAS		Chronic obstructive pulmonary disease ( 30804561 ) Estimated glomerular filtration rate ( 31152163 ) Kawasaki disease ( 21326860 )	Hip circumference adjusted for BMI ( 34021172 ) Systolic blood pressure ( 27618452 )
Novel Interactors		1 novel interactors: TRAF7	None recorded
Interacting Genes		12 interacting genes: DSCAM DSCR9 LNX1 MPP3 MTNR1B PSMD5 RNF4 RSPH1 TOP1 TRIM5 TULP3 UBC	11 interacting genes: APP BTBD1 BTBD2 CASTOR1 FILNC1 LCOR LNX2 PSMC1 PSMC2 PSMD2 TFCP2
Entrez ID		53339	5711
HPRD ID		12251	05121
Ensembl ID		ENSG00000064726	ENSG00000095261
Uniprot IDs		Q9H0C5	Q16401
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Ubiquitin Protein Ligase Activity Protein Modification By Small Protein Conjugation Ubiquitin-protein Transferase Activity Protein Ubiquitination Post-translational Protein Modification	Proteasome Regulatory Particle, Base Subcomplex Proteasome Accessory Complex Proteasome-activating Activity Proteasome Complex Proteasome Regulatory Particle P-body Regulation Of Protein Catabolic Process Positive Regulation Of Proteolysis Positive Regulation Of Protein Catabolic Process Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Proteolysis Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cytoplasmic Ribonucleoprotein Granule Proteasome Storage Granule Molecular Sensor Activity Cellular Response To L-arginine Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Positive Regulation Of Proteasomal Protein Catabolic Process Secretory Granule Lumen Neurogenesis Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Main Axon Proteasomal Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Ficolin-1-rich Granule Lumen Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway