DAPK2

Description		death associated protein kinase 2
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Golgi Apparatus Cytoplasmic Vesicle Autophagosome Lumen
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding Calmodulin Binding ATP Binding Kinase Activity Transferase Activity Identical Protein Binding Protein Serine Kinase Activity
	Biological Process	Protein Phosphorylation Apoptotic Process Regulation Of Autophagy Intracellular Signal Transduction Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Anoikis Protein Autophosphorylation Positive Regulation Of Neutrophil Chemotaxis Neutrophil Migration Positive Regulation Of Eosinophil Chemotaxis Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Caspase activation via Dependence Receptors in the absence of ligand
Drugs		Fostamatinib
Diseases
GWAS		Arterial stiffness index ( 31235810) Cerebral amyloid deposition (PET imaging) ( 30361487) Cerebrospinal fluid t-tau:AB1-42 ratio ( 28641921) HDL cholesterol levels ( 32203549) Platelet distribution width ( 27863252) Systolic blood pressure x dichotomous lifestyle risk score interaction (1df test) ( 32227373) Systolic blood pressure x dichotomous lifestyle risk score interaction (2df test) ( 32227373) Triglyceride levels ( 31647587) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683)
Novel Interacting Genes		2 novel interacting genes: ATP6V0B STK4
Interacting Genes		6 interacting genes: APP CAMK2A CCDC91 FAM9B MLC1 TGFBR1
Entrez ID		23604
HPRD ID		09905
Ensembl ID		ENSG00000035664
Uniprot IDs		Q1RMF4 Q9UIK4
PDB IDs		1WMK 1WRZ 1Z9X 1ZUZ 1ZWS 2A27 2A2A 2CKE 6PAW 7A6R 7A6Y
Enriched GO Terms of Interacting Partners?		Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Apoptotic Signaling Pathway Response To Cholesterol Membrane Raft Peptidyl-serine Phosphorylation Endosome Amyloid-beta Complex Regulation Of Neuronal Synaptic Plasticity Growth Cone Lamellipodium Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Response To Calcium Ion Regulation Of Developmental Growth Amylin Binding Positive Regulation Of Toll Signaling Pathway Peptidyl-threonine Autophosphorylation Protein Phosphorylation Positive Regulation Of Hepatocyte Apoptotic Process Identical Protein Binding Regulation Of Cell Migration Regulation Of Apoptotic Signaling Pathway Phosphorylation Protein Serine/threonine Kinase Activity Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Locomotion Endosome To Plasma Membrane Transport Vesicle Protein Tetramerization Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Regulation Of Cell Motility Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Protein Autophosphorylation Protein Kinase Activity Regulation Of Endocannabinoid Signaling Pathway Regulation Of Organ Growth Positive Regulation Of Substrate-dependent Cell Migration, Cell Attachment To Substrate Proepicardium Development Angiogenesis Involved In Coronary Vascular Morphogenesis Vascular Endothelial Cell Proliferation Epicardium Morphogenesis Transforming Growth Factor Beta Ligand-receptor Complex Negative Regulation Of Canonical Wnt Signaling Pathway
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