TTC39A and ATP6V0B

Data Source: HiPPIP (Novel)

		TTC39A	ATP6V0B
Name		tetratricopeptide repeat domain 39A	ATPase H+ transporting V0 subunit b
Structure		No pdb structure
GO Annotations	Cellular Component	Centrosome	Golgi Membrane Vacuolar Proton-transporting V-type ATPase, V0 Domain Lysosomal Membrane Endosome Plasma Membrane Endosome Membrane Membrane Clathrin-coated Vesicle Membrane Phagocytic Vesicle Membrane Cytoplasmic Vesicle Proton-transporting V-type ATPase Complex Proton-transporting Two-sector ATPase Complex, Proton-transporting Domain Proton-transporting V-type ATPase, V0 Domain
	Molecular Function	Protein Binding	Protein Binding Proton Transmembrane Transporter Activity Proton-transporting ATPase Activity, Rotational Mechanism
	Biological Process	None	Monoatomic Ion Transport Vacuolar Acidification Lysosomal Lumen Acidification Regulation Of Macroautophagy Endosomal Lumen Acidification Intracellular PH Reduction Golgi Lumen Acidification Proton Transmembrane Transport
Pathways		None	ROS and RNS production in phagocytes Insulin receptor recycling Transferrin endocytosis and recycling Amino acids regulate mTORC1 Ion channel transport Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy
Drugs		None	Tiludronic acid
GWAS		Hip circumference adjusted for BMI ( 34021172 ) Lymphocyte percentage of white cells ( 27863252 )	Autism spectrum disorder or schizophrenia ( 28540026 )
Novel Interactors		2 novel interactors: ATP6V0B NRDC	6 novel interactors: BPI CCL19 DAPK2 RPS26P15 TTC39A ZFYVE9
Interacting Genes		1 interacting genes: TNIP1	28 interacting genes: ADGRG3 ADRB2 APOD COL4A5 EMP1 FAM210B FAS GJA8 GPR42 GPR61 INSIG2 IRAK3 KLRC1 MFF MIP MS4A3 MTNR1B NRM SLC10A1 SLC2A5 SNTA1 SPACA1 STOM TM4SF19 TMEM242 VMA21 YWHAE YWHAG
Entrez ID		22996	533
HPRD ID		10727	04759
Ensembl ID		ENSG00000085831	ENSG00000117410
Uniprot IDs		A0A0A0MRQ0 A0A0A0MSW9 A0A140VJY6 A0A7P0T922 B7Z4W9 F6WE04 Q5SRH9	E9PNL3 Q99437
PDB IDs		Not available	6WLW 6WM2 6WM3 6WM4 7U4T 7UNF
GO Terms Enriched among Interactors		None	Membrane Specific Granule Membrane Gap Junction-mediated Intercellular Transport Protein Sequestering Activity Intercellular Transport