DMRTB1 and CPSF7

Number of citations of the paper that reports this interaction (PubMedID 34133714)
84

Data Source:
BioGRID (two hybrid)

		DMRTB1	CPSF7
Description		DMRT like family B with proline rich C-terminal 1	cleavage and polyadenylation specific factor 7
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus	Nucleus Nucleoplasm Cytoplasm MRNA Cleavage And Polyadenylation Specificity Factor Complex MRNA Cleavage Factor Complex Membrane
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Sequence-specific DNA Binding Metal Ion Binding	Nucleic Acid Binding RNA Binding MRNA Binding Protein Binding
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Sex Differentiation	MRNA Processing MRNA 3'-end Processing Protein Tetramerization Protein Heterotetramerization MRNA Alternative Polyadenylation Co-transcriptional MRNA 3'-end Processing, Cleavage And Polyadenylation Pathway
Pathways			mRNA 3'-end processing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Termination Processing of Intronless Pre-mRNAs RHOBTB1 GTPase cycle
Drugs
Diseases
GWAS		Cerebrospinal fluid AB1-42 levels ( 28247064) Response to statin therapy ( 20339536)
Interacting Genes		90 interacting genes: ALG13 ANKHD1 BAG4 BCAS2 C1orf94 CCND3 CDKN2D CPEB2 CPSF7 CTBP1 CTBP2 EWSR1 EXOSC1 EXOSC5 EXOSC7 EYA2 FXR2 HNRNPUL1 IL16 INCA1 KAT5 KIF21B KRT81 KRTAP19-5 KRTAP19-6 KRTAP21-2 KRTAP8-1 LARP4B LENG8 MAZ MBNL1 MRPL44 MSI2 MTPAP NCKIPSD NEDD9 NIF3L1 NIP7 NXF1 PARD6G PATL1 PEF1 PKP2 PPIL3 PRMT2 PRPF39 PRPF6 PRR3 PRRC2B QKI RAMAC RBFOX1 RBFOX2 RBM14 RBM22 RBM42 RBM7 RBPMS RPA2 RPS28 SECISBP2 SF1 SF3B4 SFPQ SH3RF1 SLAIN1 SLIRP SNRPA SNRPB SNRPC SNRPN SNW1 SORBS3 SRSF2 TENT5A TEX10 TLE5 TNRC6A TOX TRNAU1AP TSG101 TXNL4A UBL5 UNKL VASP WBP4 YTHDF1 YTHDF3 ZC3H10 ZMAT5	106 interacting genes: ALG13 APBB1 ARMC7 ATXN1 BAG4 BCAS2 CATSPER1 CD2BP2 CEBPA CEP55 CFAP206 CLK2 CSNK2A1 CTBP1 CTTN DMRTB1 DRC4 DVL2 EIF4ENIF1 EPM2AIP1 ESS2 EWSR1 EXOSC1 EXOSC5 EXOSC8 GCC1 GRB2 GTSE1 GUCD1 HINT1 HNRNPF ITCH KHDRBS3 KRT31 LENG1 LENG8 LNX1 LSM5 MAGOH MAILR MIR1-1 MIR1-2 MIR10B MIR128-2 MIR141 MIR155 MIR16-1 MIR17 MIR18B MIR199A1 MIR19A MIR19B1 MIR25 MIR29C MIR34B MIR7-1 MIR9-2 MIR93 MIRLET7B MREG NCK2 NIP7 NUDT21 NXF1 OGT PATZ1 PID1 PQBP1 PRKAA2 PRMT2 PRPF6 QKI RBFOX2 RBM10 RBM7 RBPMS RUNX1T1 SEC23B SF1 SF3B4 SFPQ SLAIN1 SMAD3 SNRNP25 SNRPC SNRPF SNW1 SNX18 SORBS3 SPG21 SRPK2 SRSF1 SRSF4 SUMO2 SUPT5H TFIP11 TLE5 TNS2 TUT4 TXNL4A U2AF2 UNKL WBP4 WWOX YTHDF1 YTHDF3
Entrez ID		63948	79869
HPRD ID		16828	16906
Ensembl ID		ENSG00000143006	ENSG00000149532
Uniprot IDs		I6L9A0 Q96MA1	B4DGF8 Q8N684
PDB IDs			3N9U
Enriched GO Terms of Interacting Partners?		RNA Binding MRNA Processing RNA Processing MRNA Metabolic Process RNA Splicing Nucleic Acid Binding MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Metabolic Process Nucleic Acid Metabolic Process Spliceosomal Complex Regulation Of MRNA Metabolic Process Nucleus MRNA Binding Nucleobase-containing Compound Metabolic Process Regulation Of RNA Splicing Nucleoplasm Cytoplasmic Stress Granule Regulation Of MRNA Splicing, Via Spliceosome Protein Binding Regulation Of MRNA Processing U1 SnRNP Macromolecule Metabolic Process U4/U6 X U5 Tri-snRNP Complex Catalytic Step 2 Spliceosome Negative Regulation Of Macromolecule Metabolic Process U2-type Prespliceosome Regulation Of Alternative MRNA Splicing, Via Spliceosome Regulation Of Macromolecule Metabolic Process U5 SnRNP Spliceosomal Complex Assembly Negative Regulation Of Metabolic Process U2-type Precatalytic Spliceosome Negative Regulation Of RNA Metabolic Process Protein-RNA Complex Assembly Transcription Corepressor Activity Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Membraneless Organelle Assembly Nucleolar Exosome (RNase Complex) Negative Regulation Of MRNA Metabolic Process U2-type Catalytic Step 2 Spliceosome Intermediate Filament Negative Regulation Of Biosynthetic Process Regulation Of Gene Expression Ribonucleoprotein Complex Negative Regulation Of Nucleobase-containing Compound Metabolic Process Cytoplasm Regulation Of Metabolic Process Cytoplasmic Exosome (RNase Complex)	MiRNA-mediated Post-transcriptional Gene Silencing RISC Complex MRNA Metabolic Process Regulatory NcRNA-mediated Post-transcriptional Gene Silencing RNA Splicing, Via Transesterification Reactions MRNA Processing RNA Splicing Post-transcriptional Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression MRNA Splicing, Via Spliceosome Regulatory NcRNA-mediated Gene Silencing RNA Processing Negative Regulation Of Biosynthetic Process Regulation Of MRNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Spliceosomal Complex Negative Regulation Of Gene Expression RNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process RNA Binding Regulation Of Gene Expression Regulation Of RNA Splicing Regulation Of Macromolecule Metabolic Process MRNA 3'-UTR Binding Regulation Of Metabolic Process Regulation Of MRNA Splicing, Via Spliceosome Nuclear Speck Regulation Of MRNA Processing Positive Regulation Of MRNA Metabolic Process Nucleic Acid Metabolic Process Positive Regulation Of MRNA Catabolic Process Regulation Of MRNA Stability Nucleic Acid Binding Nucleoplasm MRNA Binding Regulation Of RNA Stability MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Translation Regulation Of Primary Metabolic Process Catalytic Step 2 Spliceosome Regulation Of RNA Metabolic Process Regulation Of Translation Regulation Of Nucleobase-containing Compound Metabolic Process MRNA Destabilization Positive Regulation Of Catabolic Process Regulation Of Cardiac Muscle Hypertrophy RNA Destabilization
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