DMRTB1 and PARD6G

Number of citations of the paper that reports this interaction (PubMedID 30217970)
38

Data Source:
BioGRID (two hybrid)

		DMRTB1	PARD6G
Description		DMRT like family B with proline rich C-terminal 1	par-6 family cell polarity regulator gamma
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus	Nucleus Cytoplasm Cytosol Plasma Membrane Bicellular Tight Junction Cell Cortex Membrane Apical Plasma Membrane Tight Junction Anchoring Junction PAR Polarity Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Sequence-specific DNA Binding Metal Ion Binding	Protein Binding
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Sex Differentiation	Centrosome Cycle Establishment Or Maintenance Of Cell Polarity Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Cell Division Regulation Of Cellular Localization
Pathways			Tight junction interactions
Drugs
Diseases
GWAS		Cerebrospinal fluid AB1-42 levels ( 28247064) Response to statin therapy ( 20339536)
Interacting Genes		90 interacting genes: ALG13 ANKHD1 BAG4 BCAS2 C1orf94 CCND3 CDKN2D CPEB2 CPSF7 CTBP1 CTBP2 EWSR1 EXOSC1 EXOSC5 EXOSC7 EYA2 FXR2 HNRNPUL1 IL16 INCA1 KAT5 KIF21B KRT81 KRTAP19-5 KRTAP19-6 KRTAP21-2 KRTAP8-1 LARP4B LENG8 MAZ MBNL1 MRPL44 MSI2 MTPAP NCKIPSD NEDD9 NIF3L1 NIP7 NXF1 PARD6G PATL1 PEF1 PKP2 PPIL3 PRMT2 PRPF39 PRPF6 PRR3 PRRC2B QKI RAMAC RBFOX1 RBFOX2 RBM14 RBM22 RBM42 RBM7 RBPMS RPA2 RPS28 SECISBP2 SF1 SF3B4 SFPQ SH3RF1 SLAIN1 SLIRP SNRPA SNRPB SNRPC SNRPN SNW1 SORBS3 SRSF2 TENT5A TEX10 TLE5 TNRC6A TOX TRNAU1AP TSG101 TXNL4A UBL5 UNKL VASP WBP4 YTHDF1 YTHDF3 ZC3H10 ZMAT5	11 interacting genes: AKAP9 CASK CDC42 DMRTB1 KIFAP3 NDEL1 PARD3 PRKCI PRKCZ RAC1 RBM14
Entrez ID		63948	84552
HPRD ID		16828	10138
Ensembl ID		ENSG00000143006	ENSG00000178184
Uniprot IDs		I6L9A0 Q96MA1	Q9BYG4
PDB IDs
Enriched GO Terms of Interacting Partners?		RNA Binding MRNA Processing RNA Processing MRNA Metabolic Process RNA Splicing Nucleic Acid Binding MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Metabolic Process Nucleic Acid Metabolic Process Spliceosomal Complex Regulation Of MRNA Metabolic Process Nucleus MRNA Binding Nucleobase-containing Compound Metabolic Process Regulation Of RNA Splicing Nucleoplasm Cytoplasmic Stress Granule Regulation Of MRNA Splicing, Via Spliceosome Protein Binding Regulation Of MRNA Processing U1 SnRNP Macromolecule Metabolic Process U4/U6 X U5 Tri-snRNP Complex Catalytic Step 2 Spliceosome Negative Regulation Of Macromolecule Metabolic Process U2-type Prespliceosome Regulation Of Alternative MRNA Splicing, Via Spliceosome Regulation Of Macromolecule Metabolic Process U5 SnRNP Spliceosomal Complex Assembly Negative Regulation Of Metabolic Process U2-type Precatalytic Spliceosome Negative Regulation Of RNA Metabolic Process Protein-RNA Complex Assembly Transcription Corepressor Activity Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Membraneless Organelle Assembly Nucleolar Exosome (RNase Complex) Negative Regulation Of MRNA Metabolic Process U2-type Catalytic Step 2 Spliceosome Intermediate Filament Negative Regulation Of Biosynthetic Process Regulation Of Gene Expression Ribonucleoprotein Complex Negative Regulation Of Nucleobase-containing Compound Metabolic Process Cytoplasm Regulation Of Metabolic Process Cytoplasmic Exosome (RNase Complex)	PAR Polarity Complex Establishment Or Maintenance Of Apical/basal Cell Polarity Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Establishment Or Maintenance Of Cell Polarity Microtubule-based Process Establishment Of Cell Polarity Cytoskeleton Organization Centrosome Localization Organelle Organization Tight Junction Cell-cell Junction Organization Cell-cell Junction Cell Leading Edge G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Axon Hillock Cellular Localization Glutamatergic Synapse Thioesterase Binding Establishment Of Organelle Localization Neuron Projection Morphogenesis Cell Projection Morphogenesis Organelle Transport Along Microtubule Intracellular Protein Localization Microtubule Organizing Center Positive Regulation Of Ruffle Assembly Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Diacylglycerol-dependent Serine/threonine Kinase Activity Positive Regulation Of Cell Projection Organization Bicellular Tight Junction Cerebral Cortex Radially Oriented Cell Migration GTP-dependent Protein Binding Regulation Of Cell Adhesion Establishment Of Apical/basal Cell Polarity Establishment Of Monopolar Cell Polarity Establishment Or Maintenance Of Monopolar Cell Polarity Regulation Of Protein-containing Complex Assembly Positive Regulation Of Lamellipodium Assembly Microtubule Cytoskeleton Organization Positive Regulation Of Supramolecular Fiber Organization Organelle Localization Establishment Of Epithelial Cell Polarity Transport Along Microtubule Phagocytosis, Engulfment Cell Junction Organization Regulation Of Ruffle Assembly Cerebral Cortex Cell Migration Microtubule Nucleation Cell Cortex Wnt Signaling Pathway, Planar Cell Polarity Pathway Positive Regulation Of Cytoskeleton Organization
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