PKP2 and DDX11

Data Source: HiPPIP (Novel)

		PKP2	DDX11
Name		plakophilin 2	DEAD/H-box helicase 11
Structure			No pdb structure
GO Annotations	Cellular Component	Cornified Envelope Nucleus Nucleoplasm Cytoplasm Intermediate Filament Plasma Membrane Cell-cell Junction Adherens Junction Intercalated Disc Membrane Cell Junction Desmosome Cell Tip Anchoring Junction	Chromatin Spindle Pole Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Centrosome Cytoskeleton Midbody Mitotic Cohesin Complex Extracellular Exosome
	Molecular Function	DNA Binding Protein Kinase C Binding Protein Binding Sodium Channel Regulator Activity Intermediate Filament Binding Transmembrane Transporter Binding Alpha-catenin Binding Cadherin Binding Molecular Adaptor Activity Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication	Nucleotide Binding Nucleic Acid Binding DNA Binding DNA Helicase Activity Chromatin Binding DNA Replication Origin Binding Double-stranded DNA Binding Single-stranded DNA Binding RNA Binding Single-stranded RNA Binding Helicase Activity Protein Binding ATP Binding ATP-dependent Activity, Acting On DNA ATP-dependent Activity, Acting On RNA Hydrolase Activity Hydrolase Activity, Acting On Acid Anhydrides, In Phosphorus-containing Anhydrides Isomerase Activity ATP Hydrolysis Activity 5'-3' DNA Helicase Activity Triplex DNA Binding Metal Ion Binding Iron-sulfur Cluster Binding 4 Iron, 4 Sulfur Cluster Binding G-quadruplex DNA Binding Catalytic Activity, Acting On A Nucleic Acid
	Biological Process	Desmosome Assembly Desmosome Organization Cell Adhesion Cell-cell Signaling Heart Development Positive Regulation Of Sodium Ion Transport Regulation Of Cell-substrate Adhesion Intermediate Filament Bundle Assembly Maintenance Of Animal Organ Identity Ventricular Cardiac Muscle Tissue Morphogenesis Protein Localization To Plasma Membrane Cardiac Muscle Cell Action Potential Involved In Contraction Ventricular Cardiac Muscle Cell Action Potential Cell Communication By Electrical Coupling Involved In Cardiac Conduction Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication Regulation Of Heart Rate By Cardiac Conduction Cell-cell Adhesion Regulation Of Ventricular Cardiac Muscle Cell Action Potential Maintenance Of Protein Localization At Cell Tip Regulation Of Substrate Adhesion-dependent Cell Spreading	Nucleobase-containing Compound Metabolic Process DNA Replication DNA Repair DNA Damage Response Sister Chromatid Cohesion Replication Fork Processing Negative Regulation Of Protein Binding Establishment Of Sister Chromatid Cohesion Positive Regulation Of Chromatin Binding Positive Regulation Of Sister Chromatid Cohesion Cellular Response To Hydroxyurea Cellular Response To Cisplatin Positive Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I Cellular Response To Bleomycin Nucleolar Chromatin Organization Positive Regulation Of Double-strand Break Repair
Pathways		Keratinization Formation of the cornified envelope	XBP1(S) activates chaperone genes
Diseases		Arrhythmogenic right ventricular cardiomyopathy (ARVC)	Warsaw breakage syndrome
GWAS		Atrial fibrillation ( 29892015 30061737 ) Blood protein levels ( 30072576 ) Body mass index (change over time) in lung cancer ( 28044437 ) Methadone dose in opioid dependence ( 28115739 ) Obesity-related traits ( 23251661 ) Parkinson's disease ( 27182965 32201043 ) Periodontal disease related phenotype (PCT5) ( 26962152 ) Prevalent atrial fibrillation ( 28416818 )	No GWAS studies recorded
Novel Interactors		4 novel interactors: DDX11 ITPR2 KDM5A SINHCAF	1 novel interactors: PKP2
Interacting Genes		48 interacting genes: ACTN3 AKAP9 ARMC8 BAG4 CARD9 CASK CCDC120 CCDC125 CCHCR1 CTBP1 CTNNB1 DMRTB1 DSC1 DSC2 DSG1 DSG2 DSP EIF4ENIF1 EXOSC8 FHL3 GOLGA2 GRIPAP1 GTF2IRD1 HOOK2 HSPB2 JUP KLC4 KRT18 KRT31 KRT5 MAGOHB MARK3 MTUS2 NCKIPSD NDEL1 PIBF1 PLEKHG4 POLR3A RABEP1 RBM5 RBPMS ROPN1 SMAD9 SPTA1 TEKT4 VHL VIM YWHAG	4 interacting genes: EIF4ENIF1 KAT7 PFN2 PRRC2B
Entrez ID		5318	1663
HPRD ID		04177	03095
Ensembl ID		ENSG00000057294	ENSG00000013573
Uniprot IDs		A0A8V8TPU9 A0AAQ5BGY2 Q99959	Q2NKM7 Q96FC9
PDB IDs		3TT9	Not available
GO Terms Enriched among Interactors		Desmosome Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication Cardiac Muscle Cell-cardiac Muscle Cell Adhesion Cytoskeleton Organization Cornified Envelope Regulation Of Cardiac Muscle Cell Action Potential Cytoplasm Regulation Of Ventricular Cardiac Muscle Cell Action Potential Desmosome Organization Regulation Of Heart Rate By Cardiac Conduction Intercalated Disc Cardiac Conduction Intermediate Filament-based Process Intermediate Filament Cytoskeleton Organization Intermediate Filament Cytoskeleton Regulation Of Action Potential Cytosol Regulation Of Cardiac Muscle Cell Contraction Cell Junction Scaffold Protein Binding Heterotypic Cell-cell Adhesion Microtubule Organizing Center Regulation Of Striated Muscle Contraction Structural Constituent Of Cytoskeleton Regulation Of Heart Rate Cell-cell Junction Organization Organelle Organization Catenin-TCF7L2 Complex Cell-cell Junction Homotypic Cell-cell Adhesion Intracellular Protein Localization Protein Binding Intermediate Filament Organization Cellular Response To Indole-3-methanol Regulation Of Muscle System Process Nucleus Regulation Of Cardiac Muscle Contraction Microtubule Nucleation Cell-cell Adhesion Microtubule-based Process Response To Indole-3-methanol Regulation Of Muscle Contraction Anchoring Junction Fascia Adherens Adherens Junction Focal Adhesion Protein-DNA Complex Regulation Of Heart Contraction	Maintenance Of Protein Localization At Cell Tip Histone H3K23 Acetyltransferase Activity Histone H3K4 Acetyltransferase Activity Negative Regulation Of Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Histone H3-K14 Acetyltransferase Complex Response To Dithiothreitol Regulation Of Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Modification Of Postsynaptic Actin Cytoskeleton Presynaptic Actin Cytoskeleton Organization Presynaptic Cytoskeleton Organization Negative Regulation Of Ruffle Assembly Maintenance Of Animal Organ Identity Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication Intermediate Filament Binding Regulation Of Ventricular Cardiac Muscle Cell Action Potential Alpha-catenin Binding Cell Tip Cardiac Muscle Cell-cardiac Muscle Cell Adhesion Intermediate Filament Bundle Assembly Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication Desmosome Assembly Internal Protein Amino Acid Acetylation Response To Anisomycin Internal Peptidyl-lysine Acetylation DNA Replication-dependent Chromatin Disassembly Response To Hydroxyurea Histone H4K8 Acetyltransferase Activity Histone H4K12 Acetyltransferase Activity Histone H3K14 Acetyltransferase Activity Histone H4K16 Acetyltransferase Activity Response To Sorbitol Histone H3 Acetyltransferase Activity Histone H4K5 Acetyltransferase Activity Response To Actinomycin D Positive Regulation Of Hematopoietic Stem Cell Proliferation Histone H4 Acetyltransferase Activity Nuclear Export Signal Receptor Activity Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Peptidyl-lysine Acetylation Negative Regulation Of Epithelial Cell Migration Regulation Of Actin Filament-based Process Desmosome Organization Cell Communication By Electrical Coupling Involved In Cardiac Conduction Regulation Of DNA-templated DNA Replication Initiation DNA Replication Origin Binding P-body Assembly Ventricular Cardiac Muscle Cell Action Potential Regulation Of Hematopoietic Stem Cell Proliferation Natural Killer Cell Differentiation Modification Of Postsynaptic Structure