PKP2 and ITPR2

		PKP2	ITPR2
Description		plakophilin 2	inositol 1,4,5-trisphosphate receptor type 2
Image			No pdb structure
GO Annotations	Cellular Component	Cornified Envelope Nucleus Nucleoplasm Cytoplasm Intermediate Filament Plasma Membrane Cell-cell Junction Adherens Junction Intercalated Disc Membrane Cell Junction Desmosome Cell Tip Anchoring Junction	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Cell Cortex Membrane Sarcoplasmic Reticulum Transport Vesicle Membrane Secretory Granule Membrane Platelet Dense Tubular Network Membrane Cytoplasmic Vesicle Sarcoplasmic Reticulum Membrane Receptor Complex
	Molecular Function	DNA Binding Protein Kinase C Binding Protein Binding Sodium Channel Regulator Activity Intermediate Filament Binding Transmembrane Transporter Binding Alpha-catenin Binding Cadherin Binding Molecular Adaptor Activity Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication	Nucleotide Binding Monoatomic Ion Channel Activity Inositol 1,4,5-trisphosphate-gated Calcium Channel Activity Calcium Channel Activity Calcium Ion Binding ATP Binding Calcium Ion Transmembrane Transporter Activity Intracellularly Gated Calcium Channel Activity Phosphatidylinositol Binding Transmembrane Transporter Binding Metal Ion Binding Inositol 1,4,5 Trisphosphate Binding Scaffold Protein Binding
	Biological Process	Desmosome Assembly Desmosome Organization Cell Adhesion Cell-cell Signaling Heart Development Positive Regulation Of Sodium Ion Transport Regulation Of Cell-substrate Adhesion Intermediate Filament Bundle Assembly Maintenance Of Animal Organ Identity Ventricular Cardiac Muscle Tissue Morphogenesis Protein Localization To Plasma Membrane Cardiac Muscle Cell Action Potential Involved In Contraction Ventricular Cardiac Muscle Cell Action Potential Cell Communication By Electrical Coupling Involved In Cardiac Conduction Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication Regulation Of Heart Rate By Cardiac Conduction Cell-cell Adhesion Regulation Of Ventricular Cardiac Muscle Cell Action Potential Maintenance Of Protein Localization At Cell Tip Regulation Of Substrate Adhesion-dependent Cell Spreading	Response To Hypoxia Monoatomic Ion Transport Calcium Ion Transport Signal Transduction Calcium-mediated Signaling Monoatomic Ion Transmembrane Transport Release Of Sequestered Calcium Ion Into Cytosol Transmembrane Transport Calcium Ion Transmembrane Transport Cellular Response To CAMP Cellular Response To Ethanol
Pathways		Keratinization Formation of the cornified envelope	PLC beta mediated events Effects of PIP2 hydrolysis Elevation of cytosolic Ca2+ levels DAG and IP3 signaling Role of phospholipids in phagocytosis FCERI mediated Ca+2 mobilization Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Ca2+ pathway Regulation of insulin secretion VEGFR2 mediated cell proliferation Ion homeostasis Ion homeostasis CLEC7A (Dectin-1) induces NFAT activation FCGR3A-mediated IL10 synthesis Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs			Caffeine
Diseases		Arrhythmogenic right ventricular cardiomyopathy (ARVC)
GWAS		Atrial fibrillation ( 29892015 30061737) Blood protein levels ( 30072576) Body mass index (change over time) in lung cancer ( 28044437) Methadone dose in opioid dependence ( 28115739) Obesity-related traits ( 23251661) Parkinson's disease ( 27182965 32201043) Periodontal disease related phenotype (PCT5) ( 26962152) Prevalent atrial fibrillation ( 28416818)	A body shape index ( 34021172) Alanine aminotransferase levels ( 33547301) Amyotrophic lateral sclerosis ( 17827064) Birth weight ( 31043758 27680694) BRCA1/2-negative high-risk breast cancer ( 30323354) Femur bone mineral density x serum urate levels interaction ( 34046847) HDL cholesterol levels in HIV infection ( 33109212) Heel bone mineral density ( 30598549) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Kashin-Beck disease ( 25303641) LDL cholesterol levels ( 32203549) Lipid traits (pleiotropy) (HIPO component 1) ( 30289880) Liver enzyme levels (alanine transaminase) ( 33972514) Lymphocyte count ( 32888494) Major depressive disorder ( 27479909) Male-pattern baldness ( 27182965) Offspring birth weight ( 31043758) Plateletcrit ( 32888494) Refractive error ( 32231278) Renal cell carcinoma ( 31231134 22010048) Retinitis pigmentosa ( 33514863) Serum alkaline phosphatase levels ( 33547301) Smooth-surface caries ( 24556642) Type 2 diabetes ( 30297969 30054458) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for body mass index ( 28448500 34021172) Waist-hip index ( 34021172) Waist-hip ratio ( 20935629 25673412) Waist-to-hip ratio adjusted for BMI ( 34021172 26426971) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for BMI in non-smokers ( 28443625) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) Waist-to-hip ratio adjusted for body mass index ( 25673412 28448500)
Interacting Genes		48 interacting genes: ACTN3 AKAP9 ARMC8 BAG4 CARD9 CASK CCDC120 CCDC125 CCHCR1 CTBP1 CTNNB1 DMRTB1 DSC1 DSC2 DSG1 DSG2 DSP EIF4ENIF1 EXOSC8 FHL3 GOLGA2 GRIPAP1 GTF2IRD1 HOOK2 HSPB2 JUP KLC4 KRT18 KRT31 KRT5 MAGOHB MARK3 MTUS2 NCKIPSD NDEL1 PIBF1 PLEKHG4 POLR3A RABEP1 RBM5 RBPMS ROPN1 SMAD9 SPTA1 TEKT4 VHL VIM YWHAG	5 interacting genes: BANK1 LINC01554 PRKACA TRPC1 TRPC4
Entrez ID		5318	3709
HPRD ID		04177	02536
Ensembl ID		ENSG00000057294	ENSG00000123104
Uniprot IDs		A0A8V8TPU9 A0AAQ5BGY2 Q99959	Q14571
PDB IDs		3TT9
Enriched GO Terms of Interacting Partners?		Desmosome Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication Cardiac Muscle Cell-cardiac Muscle Cell Adhesion Cytoskeleton Organization Cornified Envelope Regulation Of Cardiac Muscle Cell Action Potential Cytoplasm Regulation Of Ventricular Cardiac Muscle Cell Action Potential Desmosome Organization Regulation Of Heart Rate By Cardiac Conduction Intercalated Disc Cardiac Conduction Intermediate Filament-based Process Intermediate Filament Cytoskeleton Organization Intermediate Filament Cytoskeleton Regulation Of Action Potential Cytosol Regulation Of Cardiac Muscle Cell Contraction Cell Junction Scaffold Protein Binding Heterotypic Cell-cell Adhesion Microtubule Organizing Center Regulation Of Striated Muscle Contraction Structural Constituent Of Cytoskeleton Regulation Of Heart Rate Cell-cell Junction Organization Organelle Organization Catenin-TCF7L2 Complex Cell-cell Junction Homotypic Cell-cell Adhesion Intracellular Protein Localization Protein Binding Intermediate Filament Organization Cellular Response To Indole-3-methanol Regulation Of Muscle System Process Nucleus Regulation Of Cardiac Muscle Contraction Microtubule Nucleation Cell-cell Adhesion Microtubule-based Process Response To Indole-3-methanol Regulation Of Muscle Contraction Anchoring Junction Fascia Adherens Adherens Junction Focal Adhesion Protein-DNA Complex Regulation Of Heart Contraction	Inositol 1,4,5 Trisphosphate Binding Store-operated Calcium Channel Activity Cell Communication By Electrical Coupling Involved In Cardiac Conduction Cation Channel Complex Cell Communication By Electrical Coupling Cell Communication Involved In Cardiac Conduction Regulation Of Heart Contraction Regulation Of Cardiac Conduction Calcium Channel Complex Regulation Of Blood Circulation Regulation Of Metal Ion Transport Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Monoatomic Ion Transport Intracellular Monoatomic Cation Homeostasis Inorganic Ion Homeostasis Intracellular Monoatomic Ion Homeostasis Maintenance Of Protein Localization At Cell Tip Regulation Of Cardiac Muscle Contraction Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Calcium Channel Activity Monoatomic Cation Homeostasis Monoatomic Ion Homeostasis Regulation Of Striated Muscle Contraction Regulation Of Heart Rate Intracellular Chemical Homeostasis Regulation Of System Process Regulation Of Sequestering Of Calcium Ion Transmembrane Transporter Binding Cellular Homeostasis Regulation Of Calcium Ion Transmembrane Transport Maintenance Of Animal Organ Identity Negative Regulation Of Glycolytic Process Through Fructose-6-phosphate Protein Localization To Lipid Droplet Monoatomic Ion Channel Activity Regulation Of Muscle Contraction Positive Regulation Of Monoatomic Ion Transport Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication Intracellular Calcium Ion Homeostasis Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication Intermediate Filament Binding Positive Regulation Of Transport Cell-cell Junction CAMP-dependent Protein Kinase Activity Calcium Ion Transmembrane Transport Gamma-aminobutyric Acid Secretion Chemical Homeostasis Cardiac Muscle Cell-cardiac Muscle Cell Adhesion Desmosome Assembly Regulation Of Calcium Ion Transport Channel Activator Activity
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