POU1F1 and ARSA

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		POU1F1	ARSA
Description		POU class 1 homeobox 1	arylsulfatase A
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytosol	Extracellular Region Lysosome Endoplasmic Reticulum Endoplasmic Reticulum Lumen Azurophil Granule Lumen Lysosomal Lumen Extracellular Exosome
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding LncRNA Binding Sequence-specific Double-stranded DNA Binding	Arylsulfatase Activity Cerebroside-sulfatase Activity Calcium Ion Binding Protein Binding Sulfuric Ester Hydrolase Activity Hydrolase Activity Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Cell Population Proliferation Adenohypophysis Development Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II	Lipid Metabolic Process
Pathways			The activation of arylsulfatases Neutrophil degranulation Glycosphingolipid catabolism
Drugs			4-Nitrocatechol sulfate 2-Amino-3-Hydroxy-3-Phosphonooxy-Propionic Acid
Diseases		Pituitary Dwarfism (PD); Isolated growth hormone deficiency (IGHD); Short Stature and Pituitary Defects (SSPD); Insulin-like growth factor 1 deficiency (IGFD)	Metachromatic leukodystrophy (MLD)
GWAS		Menarche (age at onset) ( 25231870) Tourette's syndrome or obsessive-compulsive disorder ( 25158072)	Aspartate aminotransferase levels ( 33547301) Fibrinogen ( 23969696) Fibrinogen levels ( 28107422) QT interval (ambient particulate matter interaction) ( 28749367) Urinary metabolite levels in chronic kidney disease ( 31959995) vWF and FVIII levels ( 30586737)
Interacting Genes		22 interacting genes: ARID5A ARSA CREBBP ETS1 GATA2 JUN KRTAP10-8 KRTAP15-1 KRTAP6-1 LASP1 LHX4 MSX2 NCOR1 NR1I2 NR1I3 NR3C1 PITX1 PPARA PPARG RAD54L2 UBE2I VDR	18 interacting genes: ANXA11 BMPR2 CAMK2B CCDC22 CETN2 CLEC4G CTSL EID2B FOXI1 GAL3ST1 PKN1 POU1F1 PPIC PROP1 RHOXF2 SNCA TRIP13 VENTX
Entrez ID		5449	410
HPRD ID		01409	09617
Ensembl ID		ENSG00000064835	ENSG00000100299
Uniprot IDs		P28069	A0A0C4DFZ2 B4DVI5 P15289
PDB IDs		5WC9	1AUK 1E1Z 1E2S 1E33 1E3C 1N2K 1N2L 2AIJ 2AIK 2HI8
Enriched GO Terms of Interacting Partners?		Sequence-specific DNA Binding Regulation Of MiRNA Transcription Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II Regulation Of MiRNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Nuclear Receptor Activity Regulation Of Transcription By RNA Polymerase II Chromatin Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Regulation Of DNA-templated Transcription RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process DNA-binding Transcription Factor Activity RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of MiRNA Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Transcription Regulator Complex Positive Regulation Of MiRNA Metabolic Process Sequence-specific Double-stranded DNA Binding Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Intracellular Receptor Signaling Pathway Positive Regulation Of Biosynthetic Process Negative Regulation Of Metabolic Process Transcription Cis-regulatory Region Binding Nuclear Retinoid X Receptor Binding Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of MiRNA Transcription Cell Differentiation Nuclear Receptor-mediated Signaling Pathway Cellular Developmental Process Positive Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific
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