POU1F1 and LASP1

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		POU1F1	LASP1
Name		POU class 1 homeobox 1	LIM and SH3 protein 1
Structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytosol	Cytoplasm Cytoskeleton Focal Adhesion Cell Cortex Cortical Actin Cytoskeleton Postsynapse
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding LncRNA Binding Sequence-specific Double-stranded DNA Binding	Actin Binding Protein Binding Monoatomic Ion Transmembrane Transporter Activity Cadherin Binding Metal Ion Binding Actin Filament Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Cell Population Proliferation Adenohypophysis Development Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II	Monoatomic Ion Transport Monoatomic Ion Transmembrane Transport
Diseases		Pituitary Dwarfism (PD); Isolated growth hormone deficiency (IGHD); Short Stature and Pituitary Defects (SSPD); Insulin-like growth factor 1 deficiency (IGFD)	None
GWAS		Menarche (age at onset) ( 25231870 ) Tourette's syndrome or obsessive-compulsive disorder ( 25158072 )	Cognitive decline rate in late mild cognitive impairment ( 26252872 ) Peginterferon alfa-2a treatment response in chronic hepatitis B infection ( 30972912 )
Novel Interactors		None recorded	1 novel interactors: ST3GAL3
Interacting Genes		22 interacting genes: ARID5A ARSA CREBBP ETS1 GATA2 JUN KRTAP10-8 KRTAP15-1 KRTAP6-1 LASP1 LHX4 MSX2 NCOR1 NR1I2 NR1I3 NR3C1 PITX1 PPARA PPARG RAD54L2 UBE2I VDR	121 interacting genes: ACD ACTA1 ACTB ACTC1 ACTMAP ANKS1A ARHGEF15 ARHGEF16 ARID5A ATXN1 BAG4 BAHD1 BHLHE40 C14orf119 CAMK2A CATSPER1 CDK7 CEBPA CERCAM CHERP COPS5 CRK CRYBA1 CRYBA2 CSTF2T CTNNA3 CYSRT1 DAZAP2 DMRT3 DNMT1 DOK6 DRC4 DTX2 EHMT2 EVX2 FAM168A FAM168B FBXO17 FHL3 FOXH1 FXR2 GCM2 GOLGA2 GUCD1 HGS HNRNPF HOXA1 INTS11 KRTAP10-8 KRTAP12-4 KRTAP19-3 KRTAP19-4 KRTAP19-6 KRTAP26-1 KRTAP3-2 KRTAP3-3 KRTAP4-2 KRTAP6-2 LENG8 LMO4 LZTS2 MDFI MED25 MGAT5B MKRN3 NOXA1 NUTF2 OTX1 OXER1 PITX1 PLSCR1 POLD1 POT1 POU1F1 PRKAR2B PRKG1 PRKG2 PRR20A PRR20B PRR20C PRR20D PRR20E PRR35 PSMA3 QRICH1 RBFOX1 RBPMS RBPMS2 REL RHOXF2 RNF38 SAXO4 SEPTIN3 SPAG8 SPRY2 STAT3 TCF4 TEKT3 TEKT4 TEKT5 TERF1 TFG THAP1 TINF2 TLX3 TNS2 TRIM27 TRIP13 UFSP1 UHRF1 VAC14 VEZF1 VGLL3 VPS37C WWOX YES1 YTHDF1 ZBTB9 ZC2HC1A ZC3H10 ZYX
Entrez ID		5449	3927
HPRD ID		01409	04229
Ensembl ID		ENSG00000064835	ENSG00000002834
Uniprot IDs		P28069	B4DIC4 Q14847
PDB IDs		5WC9	3I35
GO Terms Enriched among Interactors		Sequence-specific DNA Binding Regulation Of MiRNA Transcription Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II Regulation Of MiRNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Nuclear Receptor Activity Regulation Of Transcription By RNA Polymerase II Chromatin Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Regulation Of DNA-templated Transcription RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process DNA-binding Transcription Factor Activity RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of MiRNA Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Transcription Regulator Complex Positive Regulation Of MiRNA Metabolic Process Sequence-specific Double-stranded DNA Binding Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Intracellular Receptor Signaling Pathway Positive Regulation Of Biosynthetic Process Negative Regulation Of Metabolic Process Transcription Cis-regulatory Region Binding Nuclear Retinoid X Receptor Binding Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of MiRNA Transcription Cell Differentiation Nuclear Receptor-mediated Signaling Pathway Cellular Developmental Process Positive Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific	Identical Protein Binding Protein Binding Shelterin Complex Regulation Of Nucleobase-containing Compound Metabolic Process Intermediate Filament Nuclear Telomere Cap Complex Axonemal A Tubule Inner Sheath Positive Regulation Of Nucleobase-containing Compound Metabolic Process Telomere Capping Telomere Assembly Regulation Of RNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process Sperm Flagellum Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Flagellated Sperm Motility Sperm Motility Cilium-dependent Cell Motility Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Cilium Movement Involved In Cell Motility Telomeric DNA Binding Neuron Fate Specification Regulation Of Macromolecule Metabolic Process CGMP-dependent Protein Kinase Activity Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Cytoplasmic Stress Granule DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Negative Regulation Of DNA Biosynthetic Process Chromatin Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression Nucleus DNA Binding Positive Regulation Of Metabolic Process Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Negative Regulation Of Telomere Maintenance Regulation Of Metabolic Process Cilium Movement Negative Regulation Of Chromosome Organization Regulation Of Telomere Maintenance Via Telomerase Transcription Regulator Complex Mesenchyme Migration