PITPNA and PIK3C3

Number of citations of the paper that reports this interaction (PMID 8999962)
43

Data Source:
HPRD (in vitro, in vivo)

		PITPNA	PIK3C3
Gene Name		phosphatidylinositol transfer protein, alpha	phosphatidylinositol 3-kinase, catalytic subunit type 3
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Extracellular Vesicular Exosome	Late Endosome Cytosol Axoneme Phosphatidylinositol 3-kinase Complex Membrane Midbody Phagocytic Vesicle
	Molecular Function	Lipid Binding Phosphatidylcholine Transporter Activity Phosphatidylinositol Transporter Activity	Protein Kinase Activity Protein Binding ATP Binding 1-phosphatidylinositol-3-kinase Activity
	Biological Process	Lipid Metabolic Process Axon Guidance Visual Perception Phospholipid Transport	Autophagic Vacuole Assembly Cytokinesis Toll-like Receptor Signaling Pathway Protein Phosphorylation Phospholipid Metabolic Process Phosphatidylinositol Biosynthetic Process Endosome Organization Insulin Receptor Signaling Pathway Protein Processing Toll-like Receptor 9 Signaling Pathway Phosphatidylinositol-3-phosphate Biosynthetic Process Response To Leucine Small Molecule Metabolic Process Early Endosome To Late Endosome Transport Innate Immune Response Phosphatidylinositol Phosphorylation Phosphatidylinositol-mediated Signaling Regulation Of Protein Secretion
Pathways		Axon guidance Role of second messengers in netrin-1 signaling Netrin-1 signaling	Synthesis of PIPs at the early endosome membrane Synthesis of PIPs at the Golgi membrane Insulin receptor signalling cascade Metabolism of lipids and lipoproteins IRS-mediated signalling IRS-related events IGF1R signaling cascade Synthesis of PIPs at the late endosome membrane IRS-related events triggered by IGF1R Toll-Like Receptors Cascades IRS-mediated signalling Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) Toll Like Receptor 9 (TLR9) Cascade Phospholipid metabolism PI3K Cascade PI3K Cascade Innate Immune System PI Metabolism Signaling by Insulin receptor
Drugs		1,2-Diacyl-Sn-Glycero-3-Phosphoinositol (Z,Z)-4-Hydroxy-N,N,N-Trimethyl-10-Oxo-7-[(1-Oxo-9-Octadecenyl)Oxy]-3,5,9-Trioxa-4-Phosphaheptacos-18-En-1-Aminium-4-Oxide
Diseases
GWAS			Blood trace element (Zn levels) ( 23720494) Obesity-related traits ( 23251661)
Protein-Protein Interactions		8 interactors: CSNK2B DCC EGFR NEO1 PI4KA PIK3C3 PLCG1 SCP2	6 interactors: CALM1 PIK3R4 PITPNA SUMO1 YWHAG YWHAQ
Entrez ID		5306	5289
HPRD ID		02548	04009
Ensembl ID		ENSG00000174238
Uniprot IDs		B4E1U1 Q00169	A8MYT4 Q8NEB9
PDB IDs		1UW5	3IHY 3LS8
Enriched GO Terms of Interacting Partners?		Axon Guidance Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Neuron Projection Morphogenesis Cell Morphogenesis Involved In Differentiation Neuron Projection Development Cell Projection Morphogenesis Positive Regulation Of Phosphorylation Cell Part Morphogenesis Response To External Stimulus Neuron Development Cellular Lipid Metabolic Process Cell Morphogenesis Phosphatidylinositol-mediated Signaling Neuron Differentiation Cell Projection Organization Locomotion Lipid Metabolic Process Regulation Of Phosphorylation Anatomical Structure Morphogenesis Cellular Response To Epidermal Growth Factor Stimulus Lipid Modification Response To Organic Substance Response To Epidermal Growth Factor Regulation Of Phosphorus Metabolic Process Movement Of Cell Or Subcellular Component Positive Regulation Of Protein Phosphorylation Positive Regulation Of Intracellular Transport Regulation Of Protein Kinase Activity Generation Of Neurons Phosphate-containing Compound Metabolic Process Regulation Of Kinase Activity Neurogenesis Regulation Of Blood Vessel Endothelial Cell Migration Cell Development Inositol Phosphate Metabolic Process Activation Of Phospholipase C Activity Positive Regulation Of Protein Modification Process Cellular Response To Organic Substance Positive Regulation Of Phospholipase C Activity Signal Transduction Activation Of MAPKK Activity Phospholipid Metabolic Process Organophosphate Metabolic Process Response To Stimulus Regulation Of Cellular Localization Regulation Of Protein Phosphorylation Signaling	Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Membrane Organization Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Substantia Nigra Development Cellular Localization Neural Nucleus Development Positive Regulation Of Mitochondrion Organization Protein Targeting Regulation Of Intracellular Transport Cellular Protein Localization Midbrain Development Regulation Of Mitochondrion Organization Cellular Response To Organic Substance Positive Regulation Of Transport Protein Localization Establishment Of Localization In Cell Regulation Of Protein Localization Innate Immune Response Peroxisome Degradation Response To Organonitrogen Compound Negative Regulation Of Cellular Metabolic Process Regulation Of Immune Response Intrinsic Apoptotic Signaling Pathway PML Body Organization Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Positive Regulation Of Apoptotic Signaling Pathway Intracellular Protein Transport Nervous System Development Response To Hormone Cellular Response To Insulin Stimulus Regulation Of High Voltage-gated Calcium Channel Activity Protein Localization To Nuclear Pore Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Positive Regulation Of Intracellular Transport Regulation Of Cellular Localization Regulation Of Innate Immune Response Response To Organic Substance Protein Localization To Nuclear Envelope Late Endosome To Vacuole Transport Response To Stimulus Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Anatomical Structure Development Transport Response To Insulin Regulation Of Signal Transduction Cellular Response To Peptide Hormone Stimulus Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Negative Regulation Of Protein Phosphorylation Signal Transduction
Tagcloud ?			autophagosome autophagy cdtb coregulators cyld cytolethal deltas destroys distending distension enterica esr1 functionality imported internalized javiana lc3 macrophages nontyphoidal nts salmonella serovar serovars spread toxin typhi typhimurium vacuolization wt
Tagcloud (Difference) ?			autophagosome autophagy cdtb coregulators cyld cytolethal deltas destroys distending distension enterica esr1 functionality imported internalized javiana lc3 macrophages nontyphoidal nts salmonella serovar serovars spread toxin typhi typhimurium vacuolization wt
Tagcloud (Intersection) ?