PITPNA

Description		phosphatidylinositol transfer protein alpha
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	Protein Binding Phospholipid Transporter Activity Lipid Binding Phosphatidylcholine Transporter Activity Phosphatidylinositol Transfer Activity Phosphatidylcholine Binding Phosphatidylinositol Binding Quaternary Ammonium Group Binding Phosphatidylcholine Transfer Activity Phosphatidylglycerol Binding
	Biological Process	Lipid Metabolic Process Lipid Transport Axonogenesis Visual Perception Phospholipid Transport Intermembrane Lipid Transfer
Pathways		Role of second messengers in netrin-1 signaling Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Drugs		1,2-diacyl-sn-glycero-3-phosphoinositol (Z,Z)-4-Hydroxy-N,N,N-Trimethyl-10-Oxo-7-[(1-Oxo-9-Octadecenyl)Oxy]-3,5,9-Trioxa-4-Phosphaheptacos-18-En-1-Aminium-4-Oxide
Diseases
GWAS		Metabolite levels ( 23823483) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814)
Novel Interacting Genes		1 novel interacting genes: PABPC1
Interacting Genes		9 interacting genes: CSNK2B DCC EGFR NEO1 PI4KA PIK3C3 PLCG1 SCP2 UBC
Entrez ID		5306
HPRD ID		02548
Ensembl ID		ENSG00000174238
Uniprot IDs		B4E1U1 Q00169 V9HWC5
PDB IDs		1UW5 8PQO
Enriched GO Terms of Interacting Partners?		Phosphatidylinositol-mediated Signaling Intracellular Vesicle Phosphatidylinositol Metabolic Process Phosphate-containing Compound Metabolic Process Plasma Membrane Cytosol Cellular Response To Epidermal Growth Factor Stimulus Response To Epidermal Growth Factor Multivesicular Body, Internal Vesicle Lumen Epidermal Growth Factor Receptor Signaling Pathway Phosphatidylinositol Phosphate Biosynthetic Process Glycerophospholipid Metabolic Process Reorganization Of Cellular Membranes To Establish Viral Sites Of Replication Propionyl-CoA C2-trimethyltridecanoyltransferase Activity Propanoyl-CoA C-acyltransferase Activity Cadherin Binding Glycerolipid Metabolic Process Phospholipid Metabolic Process Regulation Of Viral Life Cycle Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Negative Regulation Of Catabolic Process Negative Regulation Of Protein Catabolic Process Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Blood Vessel Endothelial Cell Migration Postsynaptic Density Membrane Dorsal/ventral Axon Guidance Cell Migration Cell Motility Spinal Cord Ventral Commissure Morphogenesis Negative Regulation Of Neuron Projection Development Response To Amino Acid Ruffle Membrane Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Focal Adhesion ERBB Signaling Pathway Epidermal Growth Factor Binding Positive Regulation Of Protein Kinase C Signaling Epidermal Growth Factor Receptor Activity Shc-EGFR Complex Lipid Metabolic Process Organophosphate Metabolic Process Peroxisome Host-mediated Perturbation Of Viral Process Positive Regulation Of Protein Lipidation Phosphatidylinositol Biosynthetic Process Phosphatidylinositol 3-kinase Complex, Class III, Type II Phosphatidylinositol 3-kinase Complex, Class III, Type I Modulation Of Process Of Another Organism Host-mediated Perturbation Of Symbiont Process
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