SERPINI1 and TSC2

Number of citations: 54 (PubMedID 21653829)
Data Source: BioGRID (two hybrid)

		SERPINI1	TSC2
Name		serpin family I member 1	TSC complex subunit 2
Structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasmic Vesicle Secretory Granule Lumen Neuronal Cell Body Perikaryon Cytoplasmic Vesicle Lumen Extracellular Exosome	Nucleus Cytoplasm Lysosome Lysosomal Membrane Golgi Apparatus Cytosol Postsynaptic Density Membrane TSC1-TSC2 Complex Synapse Perinuclear Region Of Cytoplasm
	Molecular Function	Serine-type Endopeptidase Inhibitor Activity Peptidase Inhibitor Activity	GTPase Activator Activity Protein Binding Phosphatase Binding Small GTPase Binding Protein Homodimerization Activity Hsp90 Protein Binding
	Biological Process	Central Nervous System Development Peripheral Nervous System Development Positive Regulation Of Neuron Projection Development	Neural Tube Closure Cytoplasmic Translation Protein Import Into Nucleus Endocytosis Heart Development Intracellular Protein Localization Negative Regulation Of Cell Population Proliferation Cellular Response To Starvation Vesicle-mediated Transport Positive Regulation Of Macroautophagy Regulation Of Macroautophagy Regulation Of Endocytosis Negative Regulation Of Wnt Signaling Pathway Cellular Response To Nutrient Levels Negative Regulation Of TOR Signaling TORC1 Signaling Anoikis Negative Regulation Of Translational Initiation Positive Regulation Of Translational Initiation Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Insulin Receptor Signaling Pathway Positive Chemotaxis Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Cell Cycle Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Mitophagy Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling
Pathways		None	Macroautophagy Inhibition of TSC complex formation by PKB AKT phosphorylates targets in the cytosol Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Constitutive Signaling by AKT1 E17K in Cancer TBC/RABGAPs
Diseases		None	Lymphangioleiomyomatosis (LAM) Tuberous sclerosis complex (TSC); Bourneville-Pringle disease
GWAS		Eye color (saturation) ( 30664655 ) Fast beta electroencephalogram ( 28070124 ) Heart rate ( 23534349 ) Height ( 18391951 ) Hip circumference adjusted for BMI ( 28552196 ) Metabolite levels ( 23823483 ) Skin, hair and eye pigmentation (multivariate analysis) ( 30664655 )	Major depressive disorder ( 29317602 ) Obesity-related traits ( 23251661 ) White blood cell count ( 32888494 )
Interacting Genes		3 interacting genes: PLAT PLG TSC2	61 interacting genes: ACTN2 AKT1 AKT2 AKT3 ANKRD35 BTG3 CALM1 CBY2 CCND1 CDKN1B EEF1A1 ESR1 FBXL6 FBXW5 GAPDH GRB2 GSK3B LNX1 MAPK1 MAPK3 MAPKAPK2 MDFI MKRN1 MRPL21 NEK1 PAM PHLDB1 PICK1 PIN1 PLK2 PPP1CA PPP2CA PRKAA1 PTK2 PTPN11 RAB5A RABEP1 RHEB RPL4 RPS6KA1 RPSA SEPTIN4 SERPINI1 SFN SLC13A3 SMAD2 SMAD3 SSC4D SUPT6H TK1 TRIM55 TRIM63 TSC1 UBE3A USPL1 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ
Entrez ID		5274	7249
HPRD ID		03901	01850
Ensembl ID		ENSG00000163536	ENSG00000103197
Uniprot IDs		A0A0S2Z455 Q99574	A0A2R8Y6C9 A0A2R8YDZ2 B3KWH7 H3BMQ0 P49815 Q5HYF7 X5D2U8 X5D7Q2
PDB IDs		3F02 3F5N 3FGQ	7DL2 9CE3
GO Terms Enriched among Interactors		Trans-synaptic Signaling By BDNF, Modulating Synaptic Transmission Trans-synaptic Signaling By BDNF Negative Regulation Of Fibrinolysis Trans-synaptic Signaling, Modulating Synaptic Transmission Regulation Of Fibrinolysis Fibrinolysis Positive Regulation Of Blood Coagulation Positive Regulation Of Coagulation Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Negative Regulation Of Coagulation Positive Regulation Of Wound Healing Negative Regulation Of Wound Healing Regulation Of Hemostasis Regulation Of Blood Coagulation Schaffer Collateral - CA1 Synapse Coagulation Blood Coagulation Hemostasis Serine-type Peptidase Activity Regulation Of Wound Healing Serine-type Endopeptidase Activity Regulation Of Response To Wounding Protein Processing TSC1-TSC2 Complex Positive Regulation Of Fibrinolysis Prevention Of Polyspermy Serine Protease Inhibitor Complex Regulation Of Body Fluid Levels Protein Maturation Trans-synaptic Signaling Negative Regulation Of Plasminogen Activation Synaptic Signaling Signaling Receptor Binding Protein Antigen Binding Extracellular Matrix Regulation Of Fertilization Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin Plasminogen Activation Peptidase Activity Negative Regulation Of Mitophagy Anoikis Smooth Muscle Cell Migration Modulation Of Chemical Synaptic Transmission Trophoblast Giant Cell Differentiation Regulation Of Plasminogen Activation Apolipoprotein Binding Glutamatergic Synapse Negative Regulation Of Protein Metabolic Process Labyrinthine Layer Blood Vessel Development	Intracellular Signal Transduction Protein Modification Process Protein Metabolic Process Phosphoserine Residue Binding Regulation Of TOR Signaling Cytosol TOR Signaling Negative Regulation Of TOR Signaling Protein Kinase Binding Cytoplasm TORC1 Signaling Regulation Of Intracellular Signal Transduction Regulation Of Biological Quality Intracellular Signaling Cassette Regulation Of Cell Communication Regulation Of Signaling Regulation Of TORC1 Signaling Negative Regulation Of TORC1 Signaling Regulation Of Signal Transduction Protein Domain Specific Binding Macromolecule Metabolic Process Cellular Response To Stress Protein Sequestering Activity Ciliary Basal Body Identical Protein Binding Insulin Receptor Signaling Pathway Signal Transduction Protein Kinase Activity Cellular Response To Nutrient Levels Positive Regulation Of TOR Signaling Kinase Activity Protein Phosphorylation Protein Serine Kinase Activity Regulation Of Synaptic Plasticity SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Signal Transduction Regulation Of Protein Stability Negative Regulation Of Catabolic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Organelle Organization Epidermal Growth Factor Receptor Signaling Pathway Phosphorylation Negative Regulation Of Signaling Positive Regulation Of TORC1 Signaling Negative Regulation Of Cell Communication Nucleus Regulation Of Immune Response Regulation Of Protein Metabolic Process Protein Serine/threonine Kinase Activity