SERPINB5 and PALB2

Number of citations of the paper that reports this interaction (PubMedID 25640309)
0

Data Source:
BioGRID (two hybrid)

		SERPINB5	PALB2
Description		serpin family B member 5	partner and localizer of BRCA2
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GO Annotations	Cellular Component	Cornified Envelope Extracellular Region Extracellular Space Cytoplasm Sarcoplasm	Nucleus Nucleoplasm Nuclear Speck Protein-containing Complex DNA Repair Complex
	Molecular Function	Serine-type Endopeptidase Inhibitor Activity Protein Binding	DNA Binding Protein Binding
	Biological Process	Morphogenesis Of An Epithelium Extracellular Matrix Organization Regulation Of Epithelial Cell Proliferation Prostate Gland Morphogenesis	Double-strand Break Repair Via Homologous Recombination In Utero Embryonic Development Somitogenesis Inner Cell Mass Cell Proliferation DNA Repair DNA Recombination Apoptotic Process DNA Damage Response Mesoderm Development Animal Organ Morphogenesis Multicellular Organism Growth Post-anal Tail Morphogenesis Negative Regulation Of Apoptotic Process Embryonic Organ Development
Pathways			HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Neddylation Defective homologous recombination repair (HRR) due to BRCA1 loss of function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function Impaired BRCA2 binding to PALB2 KEAP1-NFE2L2 pathway
Drugs		S,S-(2-Hydroxyethyl)Thiocysteine
Diseases			Fanconi anemia
GWAS		Adverse response to chemotherapy in breast cancer (alopecia) (anti-microtubule) ( 24025145)	Bipolar disorder ( 17554300)
Interacting Genes		26 interacting genes: AKT1 ATIC BASP1 BCAR3 CASP8 COL1A2 EEF1A1 ESR1 GOLGA4 GSTO1 HDAC1 HSP90AA1 HSP90AB1 HSPA5 KRAS LRRFIP1 MDH1 MT1H PALB2 PPIF PTBP1 SMAD4 TBP TKT UCHL5 XRCC3	31 interacting genes: BCAS3 BRCA2 CASZ1 CCL5 CST6 DIRAS3 ERRFI1 GREB1 H2BC3 H3C1 H4C1 HNRNPC IL13RA2 IL24 KLK6 LRATD2 LYPD3 MRC2 NAT2 PDS5B PRDM14 RAD51AP1 RAD51C RHOBTB2 RNF168 SERPINB5 SNAI1 THRSP USP2 USP22 XRCC3
Entrez ID		5268	79728
HPRD ID		01111	07966
Ensembl ID		ENSG00000206075	ENSG00000083093
Uniprot IDs		P36952	A0A8V8TLC8 A0A8V8TMK8 A0AAQ5BGU0 H3BN63 I3L1Z5 Q86YC2
PDB IDs		1WZ9 1XQG 1XQJ 1XU8	2W18 3EU7 7S4A 8YAP
Enriched GO Terms of Interacting Partners?		Nitric-oxide Synthase Regulator Activity Protein-containing Complex Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Nitric Oxide Metabolic Process Cytoplasm Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Apoptotic Process Regulation Of Nitric Oxide Metabolic Process Regulation Of Programmed Cell Death Negative Regulation Of Programmed Cell Death Kinase Binding Regulation Of Protein Catabolic Process Cytosol Extracellular Exosome TFIIB-class Transcription Factor Binding Telomere Maintenance COP9 Signalosome ATP-dependent Protein Folding Chaperone Animal Organ Development Nucleobase-containing Compound Metabolic Process Negative Regulation Of Apoptotic Process Telomerase Holoenzyme Complex Assembly Telomere Organization Protein Homodimerization Activity Positive Regulation Of Signal Transduction Brainstem Development Transcription Corepressor Binding Dendritic Growth Cone TPR Domain Binding Regulation Of Intracellular Signal Transduction Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Protein Folding Chaperone Negative Regulation Of Intracellular Signal Transduction PERK-mediated Unfolded Protein Response Maintenance Of Protein Localization In Endoplasmic Reticulum Negative Regulation Of PERK-mediated Unfolded Protein Response Striated Muscle Cell Differentiation Positive Regulation Of Cell Communication Regulation Of Signal Transduction Positive Regulation Of Signaling Developmental Process Negative Regulation Of Muscle Cell Differentiation Macromolecule Biosynthetic Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Striated Muscle Contraction Regulation Of Protein Ubiquitination Intracellular Signaling Cassette Positive Regulation Of Biosynthetic Process Regulation Of Growth Positive Regulation Of Cell Differentiation	Chromatin Remodeling Telomere Maintenance Via Recombination Telomere Organization Chromatin Organization Rad51C-XRCC3 Complex Mitotic Recombination Chromosome, Telomeric Region Positive Regulation Of Cell Cycle Nucleoplasm Chromosome Organization Double-strand Break Repair Interstrand Cross-link Repair DNA Recombination Positive Regulation Of Mitotic Cell Cycle Double-strand Break Repair Via Homologous Recombination Recombinational Repair Crossover Junction DNA Endonuclease Activity Cornified Envelope Histone H4 Acetyltransferase Activity Protein-DNA Complex Assembly Four-way Junction DNA Binding Structural Constituent Of Chromatin ATP-dependent DNA Damage Sensor Activity DNA Binding Telomere Maintenance Nucleosome Assembly Male Meiosis I
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