SERPINB5 and TKT

Number of citations of the paper that reports this interaction (PubMedID 11788595)
0

Data Source:
BioGRID (two hybrid)

		SERPINB5	TKT
Description		serpin family B member 5	transketolase
Image
GO Annotations	Cellular Component	Cornified Envelope Extracellular Region Extracellular Space Cytoplasm Sarcoplasm	Nucleoplasm Cytoplasm Peroxisome Endoplasmic Reticulum Membrane Cytosol Nuclear Body Vesicle Extracellular Exosome
	Molecular Function	Serine-type Endopeptidase Inhibitor Activity Protein Binding	Magnesium Ion Binding Transketolase Activity Calcium Ion Binding Protein Binding Transferase Activity Transketolase Or Transaldolase Activity Thiamine Pyrophosphate Binding Protein Homodimerization Activity Metal Ion Binding
	Biological Process	Morphogenesis Of An Epithelium Extracellular Matrix Organization Regulation Of Epithelial Cell Proliferation Prostate Gland Morphogenesis	Pentose-phosphate Shunt Pentose-phosphate Shunt, Non-oxidative Branch Glyceraldehyde-3-phosphate Metabolic Process Regulation Of Growth Glyceraldehyde-3-phosphate Biosynthetic Process D-xylulose 5-phosphate Biosynthetic Process
Pathways			Insulin effects increased synthesis of Xylulose-5-Phosphate Pentose phosphate pathway NFE2L2 regulates pentose phosphate pathway genes
Drugs		S,S-(2-Hydroxyethyl)Thiocysteine	Copper
Diseases
GWAS		Adverse response to chemotherapy in breast cancer (alopecia) (anti-microtubule) ( 24025145)	A body shape index ( 34021172) Body mass index ( 26426971) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) QRS duration ( 27577874 27659466 30012220) Refractive error ( 32231278) Serum metabolite levels ( 33031748) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		26 interacting genes: AKT1 ATIC BASP1 BCAR3 CASP8 COL1A2 EEF1A1 ESR1 GOLGA4 GSTO1 HDAC1 HSP90AA1 HSP90AB1 HSPA5 KRAS LRRFIP1 MDH1 MT1H PALB2 PPIF PTBP1 SMAD4 TBP TKT UCHL5 XRCC3	8 interacting genes: CEBPA FNDC3B ITGB1BP2 LINC01554 MYOC SERPINB5 SQSTM1 TERF1
Entrez ID		5268	7086
HPRD ID		01111	06001
Ensembl ID		ENSG00000206075	ENSG00000163931
Uniprot IDs		P36952	P29401 V9HWD9
PDB IDs		1WZ9 1XQG 1XQJ 1XU8	3MOS 3OOY 4KXU 4KXV 4KXW 4KXX 4KXY 6HA3 6HAD 6RJB 8WA8 8WA9 8WAA
Enriched GO Terms of Interacting Partners?		Nitric-oxide Synthase Regulator Activity Protein-containing Complex Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Nitric Oxide Metabolic Process Cytoplasm Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Apoptotic Process Regulation Of Nitric Oxide Metabolic Process Regulation Of Programmed Cell Death Negative Regulation Of Programmed Cell Death Kinase Binding Regulation Of Protein Catabolic Process Cytosol Extracellular Exosome TFIIB-class Transcription Factor Binding Telomere Maintenance COP9 Signalosome ATP-dependent Protein Folding Chaperone Animal Organ Development Nucleobase-containing Compound Metabolic Process Negative Regulation Of Apoptotic Process Telomerase Holoenzyme Complex Assembly Telomere Organization Protein Homodimerization Activity Positive Regulation Of Signal Transduction Brainstem Development Transcription Corepressor Binding Dendritic Growth Cone TPR Domain Binding Regulation Of Intracellular Signal Transduction Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Protein Folding Chaperone Negative Regulation Of Intracellular Signal Transduction PERK-mediated Unfolded Protein Response Maintenance Of Protein Localization In Endoplasmic Reticulum Negative Regulation Of PERK-mediated Unfolded Protein Response Striated Muscle Cell Differentiation Positive Regulation Of Cell Communication Regulation Of Signal Transduction Positive Regulation Of Signaling Developmental Process Negative Regulation Of Muscle Cell Differentiation Macromolecule Biosynthetic Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Striated Muscle Contraction Regulation Of Protein Ubiquitination Intracellular Signaling Cassette Positive Regulation Of Biosynthetic Process Regulation Of Growth Positive Regulation Of Cell Differentiation	Fat Cell Proliferation RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Energy Homeostasis Receptor Tyrosine Kinase Binding Skeletal Muscle Hypertrophy Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of Shelterin Complex Assembly Response To Vitamin B2 C/EBP Complex Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Brown Fat Cell Proliferation Amphisome CHOP-C/EBP Complex
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