IRAK1BP1

Description		interleukin 1 receptor associated kinase 1 binding protein 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm
	Molecular Function	Protein Binding Signaling Adaptor Activity
	Biological Process	Immune Response Positive Regulation Of Canonical NF-kappaB Signal Transduction
Pathways
Drugs
Diseases
GWAS		Blood pressure measurement (high sodium and potassium intervention) ( 24165912) Blood pressure measurement (high sodium intervention) ( 24165912) Blood pressure measurement (low sodium intervention) ( 24165912) Cadmium levels ( 26025379) Daytime nap ( 33568662) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Late-onset Alzheimer's disease ( 27770636) LDL cholesterol levels x loop diuretics use interaction ( 31806883) Macular thickness ( 30535121) Sjögren's syndrome ( 24097067)
Interacting Genes		11 interacting genes: IRAK1 MISP PHF1 PRKAB2 RELA RIPPLY1 SCNM1 TFCP2 UFL1 USP20 ZNF410
Entrez ID		134728
HPRD ID		17157
Ensembl ID		ENSG00000146243
Uniprot IDs		Q5VVH5
PDB IDs
Enriched GO Terms of Interacting Partners?		Canonical NF-kappaB Signal Transduction Antiviral Innate Immune Response Regulation Of Canonical NF-kappaB Signal Transduction Interleukin-1-mediated Signaling Pathway Protein Kinase Binding Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Regulation Of DNA-binding Transcription Factor Activity Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Toll-like Receptor 4 Signaling Pathway Cell Surface Toll-like Receptor Signaling Pathway Toll-like Receptor Signaling Pathway Innate Immune Response Cell Surface Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Leukocyte Cell-cell Adhesion Defense Response To Virus UFM1 Ligase Activity Positive Regulation Of Gliogenesis Positive Regulation Of Cell-cell Adhesion Response To Interleukin-1 Defense Response To Other Organism Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Intracellular Signal Transduction Protein-containing Complex Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Defense Response To Symbiont NF-kappaB P50/p65 Complex UFM1 Transferase Activity Negative Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Leukocyte Cell-cell Adhesion Cytoplasmic Pattern Recognition Receptor Signaling Pathway Regulation Of Metabolic Process Site Of Double-strand Break Regulation Of Gliogenesis Positive Regulation Of Schwann Cell Differentiation Response To Virus Negative Regulation Of Post-translational Protein Modification Response To Cobalamin Positive Regulation Of Reticulophagy Mitotic Spindle Astral Microtubule End Positive Regulation Of Metabolic Process Positive Regulation Of DNA-binding Transcription Factor Activity Response To Amino Acid Toll-like Receptor TLR6:TLR2 Signaling Pathway Regulation Of Schwann Cell Differentiation NF-kappaB Complex Prolactin Signaling Pathway Regulation Of Reticulophagy Postsynapse To Nucleus Signaling Pathway Protein K69-linked Ufmylation Somite Specification
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