IRAK1BP1 and SCNM1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		IRAK1BP1	SCNM1
Description		interleukin 1 receptor associated kinase 1 binding protein 1	sodium channel modifier 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm	Nucleus Nucleoplasm Spliceosomal Complex Nuclear Speck
	Molecular Function	Protein Binding Signaling Adaptor Activity	Protein Binding Zinc Ion Binding Enzyme Binding Metal Ion Binding
	Biological Process	Immune Response Positive Regulation Of Canonical NF-kappaB Signal Transduction	Alternative MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing
Pathways
Drugs
Diseases
GWAS		Blood pressure measurement (high sodium and potassium intervention) ( 24165912) Blood pressure measurement (high sodium intervention) ( 24165912) Blood pressure measurement (low sodium intervention) ( 24165912) Cadmium levels ( 26025379) Daytime nap ( 33568662) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Late-onset Alzheimer's disease ( 27770636) LDL cholesterol levels x loop diuretics use interaction ( 31806883) Macular thickness ( 30535121) Sjögren's syndrome ( 24097067)
Interacting Genes		11 interacting genes: IRAK1 MISP PHF1 PRKAB2 RELA RIPPLY1 SCNM1 TFCP2 UFL1 USP20 ZNF410	179 interacting genes: ADAMTSL4 AKAP9 AVPI1 AXIN2 BACH2 BEND7 BLZF1 CALCOCO2 CARD10 CARD9 CBY2 CCDC136 CCDC28B CCDC33 CCDC74B CCDC85B CDR2 CDR2L CEP44 CEP70 CEP76 CHIC2 CIB3 COG6 CTDSP1 CYSRT1 CYTIP DRC4 DVL2 EZHIP FAM161A FAM228A FANCL FHL2 FHL5 FNDC11 FRS3 FSD2 GIGYF1 GOLGA2 GOLGA6L9 GPRASP3 HAP1 HMBOX1 HMG20A HOMER3 HOMEZ HOOK2 HSF2BP IKZF1 IKZF3 INCA1 IRAK1BP1 JAKMIP1 KANK2 KATNBL1 KIFC3 KLF15 KRT27 KRT31 KRT33B KRT34 KRT35 KRT38 KRT39 KRT40 KRT75 KRTAP1-1 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP5-9 LCN2 LDOC1 LHX1 LHX3 LIMS1 LNX1 LNX2 LRP2BP LZTS1 LZTS2 MCM6 MDFI MEOX2 MID2 MIPOL1 MKRN3 MORN3 MRPL28 MSS51 MTUS2 MYLIP MYO1F NAB2 NAP1L2 NBPF19 NDUFB7 NFKBID NOTCH2NLA NUTM1 PBX4 PDE4DIP PDLIM7 PFDN5 PIBF1 PICK1 PIH1D1 PLSCR1 PNMA1 PNMA2 PPP1R16A PPP1R16B PRDM14 PRNP PRR5L PSTPIP1 RBAK RBM11 RBM48 RDM1 REL RHOH RINT1 RORB RPGRIP1 RPH3AL SMARCD1 SORBS3 SSX2IP STX11 STX19 SYCE1 TAX1BP1 TFIP11 TLE5 TNNI1 TP53BP2 TRAF1 TRAF2 TRIB3 TRIM10 TRIM23 TRIM27 TRIM37 TRIM42 TRIM54 TTC23L UBXN11 USH1G USHBP1 VIM VMAC VPS52 VWC2 ZBTB1 ZBTB14 ZDHHC17 ZGPAT ZIM2 ZMAT1 ZMYND12 ZNF135 ZNF19 ZNF20 ZNF202 ZNF438 ZNF511 ZNF526 ZNF547 ZNF552 ZNF641 ZNF688 ZNF76 ZNF774 ZNF829 ZRANB1
Entrez ID		134728	79005
HPRD ID		17157	12162
Ensembl ID		ENSG00000146243	ENSG00000163156
Uniprot IDs		Q5VVH5	Q9BWG6
PDB IDs			7DVQ 8Y7E
Enriched GO Terms of Interacting Partners?		Canonical NF-kappaB Signal Transduction Antiviral Innate Immune Response Regulation Of Canonical NF-kappaB Signal Transduction Interleukin-1-mediated Signaling Pathway Protein Kinase Binding Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Regulation Of DNA-binding Transcription Factor Activity Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Toll-like Receptor 4 Signaling Pathway Cell Surface Toll-like Receptor Signaling Pathway Toll-like Receptor Signaling Pathway Innate Immune Response Cell Surface Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Leukocyte Cell-cell Adhesion Defense Response To Virus UFM1 Ligase Activity Positive Regulation Of Gliogenesis Positive Regulation Of Cell-cell Adhesion Response To Interleukin-1 Defense Response To Other Organism Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Intracellular Signal Transduction Protein-containing Complex Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Defense Response To Symbiont NF-kappaB P50/p65 Complex UFM1 Transferase Activity Negative Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Leukocyte Cell-cell Adhesion Cytoplasmic Pattern Recognition Receptor Signaling Pathway Regulation Of Metabolic Process Site Of Double-strand Break Regulation Of Gliogenesis Positive Regulation Of Schwann Cell Differentiation Response To Virus Negative Regulation Of Post-translational Protein Modification Response To Cobalamin Positive Regulation Of Reticulophagy Mitotic Spindle Astral Microtubule End Positive Regulation Of Metabolic Process Positive Regulation Of DNA-binding Transcription Factor Activity Response To Amino Acid Toll-like Receptor TLR6:TLR2 Signaling Pathway Regulation Of Schwann Cell Differentiation NF-kappaB Complex Prolactin Signaling Pathway Regulation Of Reticulophagy Postsynapse To Nucleus Signaling Pathway Protein K69-linked Ufmylation Somite Specification	Protein Binding Keratin Filament Intermediate Filament Zinc Ion Binding Intermediate Filament Organization Structural Constituent Of Skin Epidermis Identical Protein Binding Cytoskeleton Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Microtubule Binding Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Supramolecular Fiber Organization Centrosome TORC1 Complex Assembly Structural Molecule Activity Regulation Of Transcription By RNA Polymerase II DNA Binding Cytoskeleton Organization Ubiquitin Protein Ligase Activity Negative Regulation Of Calcineurin-NFAT Signaling Cascade
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