FKBP5 and FES

Number of citations of the paper that reports this interaction (PMID 9222609)
41

Data Source:
BioGRID (pull down)

		FKBP5	FES
Gene Name		FK506 binding protein 5	FES proto-oncogene, tyrosine kinase
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Endoplasmic Reticulum Membrane Membrane Extracellular Vesicular Exosome	Cytoplasm Golgi Apparatus Cytosol Focal Adhesion Microtubule Cytoskeleton Cytoplasmic Membrane-bounded Vesicle Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Cytoplasmic Vesicle
	Molecular Function	Peptidyl-prolyl Cis-trans Isomerase Activity Protein Binding FK506 Binding Heat Shock Protein Binding	Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Immunoglobulin Receptor Binding Phosphatidylinositol Binding
	Biological Process	Protein Peptidyl-prolyl Isomerization Protein Folding Chaperone-mediated Protein Folding	Protein Phosphorylation Chemotaxis Epidermal Growth Factor Receptor Signaling Pathway Multicellular Organismal Development Axon Guidance Cell Proliferation Regulation Of Cell Shape Positive Regulation Of Neuron Projection Development Cell Migration Peptidyl-tyrosine Phosphorylation Regulation Of Cell Adhesion Positive Regulation Of Microtubule Polymerization Peptidyl-tyrosine Autophosphorylation Regulation Of Cell Proliferation Regulation Of Mast Cell Degranulation Innate Immune Response Regulation Of Cell Differentiation Positive Regulation Of Myeloid Cell Differentiation Protein Autophosphorylation Regulation Of Vesicle-mediated Transport Regulation Of Cell Motility Positive Regulation Of Actin Cytoskeleton Reorganization
Pathways			Signaling by SCF-KIT Axon guidance Semaphorin interactions Sema3A PAK dependent Axon repulsion SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion CRMPs in Sema3A signaling
Drugs
Diseases
GWAS			Blood pressure ( 21909110) Diastolic blood pressure ( 21909115) Hypertension ( 21909115) Systolic blood pressure ( 21909115)
Protein-Protein Interactions		10 interactors: APP CHUK ESR1 FES HSF1 HSP90AA1 IKBKE NR2C2 PGR STIP1	31 interactors: BCAR1 BCR CSF2RB DOK1 DPYSL5 EGFR FKBP4 FKBP5 HSH2D HSPA4 IL4R IRS1 IRS2 JAK1 JAK2 JAK3 MDFI NEDD4 PDE4DIP PIK3R1 PLXNA1 POT1 PPID PTGES3 RASA1 RASA3 STAT3 TERF1 TRIM28 ZNF746 ZNF775
Entrez ID		2289	2242
HPRD ID		04019	01814
Ensembl ID		ENSG00000096060	ENSG00000182511
Uniprot IDs		Q13451 Q2TA84	P07332
PDB IDs		1KT0 3O5D 3O5E 3O5F 3O5G 3O5I 3O5J 3O5K 3O5L 3O5M 3O5O 3O5P 3O5Q 3O5R 4DRH 4DRI 4DRK 4DRM 4DRN 4DRO 4DRP 4DRQ 4JFI 4JFJ 4JFK 4JFL 4JFM	1WQU 2DCR 3BKB 3CBL 3CD3 4DYL 4E93
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cellular Biosynthetic Process Intracellular Receptor Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter Mammary Gland Branching Involved In Pregnancy Positive Regulation Of Transcription, DNA-templated Defense Response Steroid Hormone Mediated Signaling Pathway Mammary Gland Epithelium Development Innate Immune Response Positive Regulation Of Macromolecule Biosynthetic Process Response To Lipid Positive Regulation Of Gene Expression I-kappaB Phosphorylation Positive Regulation Of Cellular Metabolic Process Hormone-mediated Signaling Pathway Response To Stimulus System Development Reproduction Mammary Gland Epithelial Cell Proliferation Regulation Of Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Mammary Gland Development Cellular Response To Steroid Hormone Stimulus Regulation Of Cellular Response To Heat Cellular Response To Stimulus Multicellular Organismal Development Immune Response DNA-templated Transcription, Initiation Anatomical Structure Development Cell Differentiation Positive Regulation Of Metabolic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Reproductive Process Protein Phosphorylation Response To Stress Female Pregnancy Regulation Of Nitric-oxide Synthase Activity Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Mammary Gland Lobule Development Mammary Gland Alveolus Development Anatomical Structure Morphogenesis Signal Transduction Branching Involved In Mammary Gland Duct Morphogenesis Response To Organic Substance Sexual Reproduction Developmental Process Multicellular Organismal Reproductive Process I-kappaB Kinase/NF-kappaB Signaling	Growth Hormone Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus Response To Growth Hormone Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Peptide Hormone Stimulus Cellular Response To Organonitrogen Compound Cellular Response To Peptide JAK-STAT Cascade Positive Regulation Of Transport Intracellular Signal Transduction Cellular Response To Hormone Stimulus Regulation Of Cellular Localization Regulation Of Cell Migration Signal Transduction Regulation Of Protein Transport Regulation Of Cell Motility Regulation Of Immune Response Response To Peptide Hormone Cellular Response To Stimulus Response To Organic Substance Regulation Of Establishment Of Protein Localization Regulation Of Locomotion Response To Peptide Regulation Of Cellular Component Movement Response To Stimulus Response To Hormone Positive Regulation Of Protein Transport Cellular Response To Organic Substance Signaling Regulation Of Cell Death Protein Autophosphorylation Cell Surface Receptor Signaling Pathway Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Nucleocytoplasmic Transport Neurotrophin TRK Receptor Signaling Pathway Cell Communication Neurotrophin Signaling Pathway Regulation Of Protein Localization Response To Organonitrogen Compound Response To Stress Cytokine-mediated Signaling Pathway Chaperone-mediated Protein Folding Insulin Receptor Signaling Pathway Protein Import Epidermal Growth Factor Receptor Signaling Pathway Peptidyl-amino Acid Modification ERBB Signaling Pathway Locomotion
Tagcloud ?		12q13 4x10 bd bdi bdnf beck bipolar dbh depression depressive dhh etiology gwas gwass gxe interplay inventory marginally mdd pcorrected personality puncorrected rs4523957 rs7296288 scz slc6a4 sles stressful unsuccessful	1d4 counterpart e1c3 electrophoretic epsilon germline heavy hela iepsilon immunoglobulin initiating irs jak1 jak3 lysates mediating mobility parental promotor pronounced radiolabeled reconstitution restored shift stat6 tyrosine undergo utilized utilizing
Tagcloud (Difference) ?		12q13 4x10 bd bdi bdnf beck bipolar dbh depression depressive dhh etiology gwas gwass gxe interplay inventory marginally mdd pcorrected personality puncorrected rs4523957 rs7296288 scz slc6a4 sles stressful unsuccessful	1d4 counterpart e1c3 electrophoretic epsilon germline heavy hela iepsilon immunoglobulin initiating irs jak1 jak3 lysates mediating mobility parental promotor pronounced radiolabeled reconstitution restored shift stat6 tyrosine undergo utilized utilizing
Tagcloud (Intersection) ?