GHSR and DRD1

Number of citations of the paper that reports this interaction (PubMedID 27129257)
29

Data Source:
BioGRID (fluorescent resonance energy transfer)

		GHSR	DRD1
Description		growth hormone secretagogue receptor	dopamine receptor D1
Image
GO Annotations	Cellular Component	Plasma Membrane Cell Surface Membrane Neuron Projection Membrane Raft Synaptic Membrane Schaffer Collateral - CA1 Synapse Postsynapse Glutamatergic Synapse	Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Cilium Endomembrane System Membrane Dendrite Presynaptic Membrane Cell Projection Dendritic Spine Synapse Postsynaptic Membrane Ciliary Membrane G Protein-coupled Receptor Complex Non-motile Cilium Glutamatergic Synapse GABA-ergic Synapse
	Molecular Function	Growth Hormone Secretagogue Receptor Activity G Protein-coupled Receptor Activity Protein Binding Growth Hormone-releasing Hormone Receptor Activity Peptide Hormone Binding Hormone Binding Identical Protein Binding	Dopamine Neurotransmitter Receptor Activity, Coupled Via Gs G-protein Alpha-subunit Binding G Protein-coupled Receptor Activity Dopamine Neurotransmitter Receptor Activity Protein Binding Heterotrimeric G-protein Binding Dopamine Binding Arrestin Family Protein Binding
	Biological Process	G Protein-coupled Receptor Internalization Signal Transduction G Protein-coupled Receptor Signaling Pathway Spermatogenesis Female Pregnancy Learning Or Memory Actin Polymerization Or Depolymerization Adult Feeding Behavior Response To Hormone Hormone-mediated Signaling Pathway Negative Regulation Of Norepinephrine Secretion Peptide Hormone Secretion Growth Hormone Secretion Response To Food Negative Regulation Of Appetite Positive Regulation Of Appetite Response To Follicle-stimulating Hormone Response To Estradiol Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Cellular Response To Insulin Stimulus Cellular Response To Hormone Stimulus Ghrelin Secretion Positive Regulation Of Multicellular Organism Growth Regulation Of Hindgut Contraction Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Fatty Acid Metabolic Process Positive Regulation Of Growth Negative Regulation Of Insulin Secretion Decidualization Insulin-like Growth Factor Receptor Signaling Pathway Negative Regulation Of Inflammatory Response Regulation Of Synapse Assembly Regulation Of Transmission Of Nerve Impulse Regulation Of Growth Hormone Secretion Regulation Of Feeding Behavior Response To Growth Hormone Cellular Response To Lipopolysaccharide Response To Dexamethasone Negative Regulation Of Locomotion Involved In Locomotory Behavior Cellular Response To Thyroid Hormone Stimulus Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Postsynaptic Modulation Of Chemical Synaptic Transmission Regulation Of Postsynapse Organization Positive Regulation Of Small Intestinal Transit Response To L-glutamate Positive Regulation Of Sprouting Angiogenesis Positive Regulation Of Eating Behavior Positive Regulation Of Small Intestine Smooth Muscle Contraction Regulation Of Gastric Motility Positive Regulation Of Vascular Endothelial Cell Proliferation Cellular Response To Insulin-like Growth Factor Stimulus Negative Regulation Of Macrophage Apoptotic Process	Temperature Homeostasis Conditioned Taste Aversion Behavioral Fear Response Neuron Migration Synaptic Transmission, Dopaminergic Response To Amphetamine Protein Import Into Nucleus Muscle Contraction Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway G Protein-coupled Dopamine Receptor Signaling Pathway Synapse Assembly Learning Memory Mating Behavior Grooming Behavior Locomotory Behavior Adult Walking Behavior Feeding Behavior Associative Learning Visual Learning Response To Xenobiotic Stimulus Astrocyte Development Dopamine Transport Cell Migration Transmission Of Nerve Impulse Neuronal Action Potential Dentate Gyrus Development Striatum Development Hippocampus Development Cerebral Cortex GABAergic Interneuron Migration Positive Regulation Of Cell Migration Peristalsis Operant Conditioning Synaptic Transmission, Glutamatergic Regulation Of Dopamine Metabolic Process Response To Cocaine Vasodilation Dopamine Metabolic Process Maternal Behavior Positive Regulation Of Potassium Ion Transport Positive Regulation Of MAPK Cascade D-glucose Import Habituation Sensitization Behavioral Response To Cocaine Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Dopamine Uptake Involved In Synaptic Transmission Positive Regulation Of Synaptic Transmission, Glutamatergic Prepulse Inhibition Phospholipase C-activating Dopamine Receptor Signaling Pathway Long-term Synaptic Potentiation Long-term Synaptic Depression Cellular Response To Catecholamine Stimulus Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Modification Of Postsynaptic Structure Presynaptic Modulation Of Chemical Synaptic Transmission Positive Regulation Of Neuron Migration
Pathways		Peptide ligand-binding receptors G alpha (q) signalling events	Dopamine receptors G alpha (s) signalling events
Drugs		Ulimorelin Macimorelin Echinacoside	Ziprasidone Cabergoline Cabergoline Olanzapine Olanzapine Methylergometrine Clozapine Phenylpropanolamine Loxapine Loxapine Imipramine Chlorpromazine Chlorpromazine Haloperidol Triflupromazine Amoxapine Lamotrigine Cinnarizine Lisuride Fluphenazine Thioridazine Ergotamine Apomorphine Paroxetine Trimipramine Risperidone Fenoldopam Minaprine Perphenazine Flupentixol Dopamine Dopamine Carphenazine Ergoloid mesylate Pergolide Bromocriptine Quetiapine Levodopa Aripiprazole Chlorprothixene Paliperidone Methotrimeprazine Periciazine Acepromazine Pipotiazine Thioproperazine Thiothixene Zuclopenthixol Iloperidone Rotigotine Lumateperone Mianserin Asenapine Nandrolone decanoate Quinagolide Zotepine Pipamperone Dihydro-alpha-ergocryptine Epicriptine Pipradrol Tetrahydropalmatine Dihydrexidine Dihydroergocristine Aripiprazole lauroxil
Diseases
GWAS		Appendicular lean mass ( 33097823) Chronotype ( 30696823) Cocaine dependence ( 31212010) Height ( 20881960 23563607 25282103 25429064 31562340) Hip circumference adjusted for BMI ( 34021172) Metabolite levels ( 23823483)	Cadmium levels ( 26025379) Chin dimples ( 27182965) Falling risk ( 32999390) Night sleep phenotypes ( 27126917) Obesity-related traits ( 23251661) Refractive error ( 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Treatment response for severe sepsis ( 22310353) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683)
Interacting Genes		5 interacting genes: CORT DRD1 GHRL LEAP2 SIGMAR1	19 interacting genes: ADA ADORA1 CALY CAV2 COPG1 COPG2 DLG4 DNAJC14 DRD3 EPB41L2 FLNA GHSR GRIN1 HRH3 MEIS2 PDCD6IP PRKACA TGIF1 VPS35
Entrez ID		2693	1812
HPRD ID		03541	00538
Ensembl ID		ENSG00000121853	ENSG00000184845
Uniprot IDs		Q92847	P21728
PDB IDs		6KO5 7F9Y 7F9Z 7NA7 7NA8 7W2Z 8JSR	7CKW 7CKX 7CKY 7CKZ 7CRH 7F0T 7F1O 7F1Z 7F23 7F24 7JOZ 7JV5 7JVP 7JVQ 7LJC 7LJD 7X2C 7X2D 7X2F 8IRR 8JXR 8JXS
Enriched GO Terms of Interacting Partners?		G Protein-coupled Receptor Signaling Pathway Hormone Activity G Protein-coupled Receptor Binding Habituation Conditioned Taste Aversion Dopamine Neurotransmitter Receptor Activity, Coupled Via Gs Operant Conditioning Sensitization G Protein-coupled Receptor Complex Synapse Assembly Glutamatergic Synapse Feeding Behavior Organic Hydroxy Compound Transport Adult Behavior Regulation Of Postsynapse Organization Regulation Of Synapse Assembly Positive Regulation Of Eating Behavior Positive Regulation Of Cortisol Secretion Ghrelin Receptor Binding Positive Regulation Of Response To Food Negative Regulation Of Circadian Sleep/wake Cycle, Sleep Regulation Of Circadian Sleep/wake Cycle, REM Sleep Positive Regulation Of Appetite Growth Hormone-releasing Hormone Activity Negative Regulation Of Circadian Sleep/wake Cycle, REM Sleep Cortisol Secretion Positive Regulation Of Small Intestinal Transit Positive Regulation Of Growth Rate Positive Regulation Of Small Intestine Smooth Muscle Contraction Regulation Of Gastric Motility Positive Regulation Of Bone Development Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Positive Regulation Of Growth Hormone Receptor Signaling Pathway Positive Regulation Of Gastric Mucosal Blood Circulation Synapse Dopamine Neurotransmitter Receptor Activity Neuronal Dense Core Vesicle Lumen Regulation Of Growth Rate Positive Regulation Of Gastro-intestinal System Smooth Muscle Contraction Regulation Of Locomotion Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Regulation Of Dopamine Uptake Involved In Synaptic Transmission Heterotrimeric G-protein Binding Interneuron Migration From The Subpallium To The Cortex Cell Junction Assembly Dopamine Binding Nonassociative Learning Phospholipase C-activating Dopamine Receptor Signaling Pathway Cerebral Cortex GABAergic Interneuron Migration Synapse Organization	Positive Regulation Of Dopamine Receptor Signaling Pathway Regulation Of Behavior Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway D1 Dopamine Receptor Binding Regulation Of Transport Regulation Of Dopamine Receptor Signaling Pathway Modulation Of Chemical Synaptic Transmission Secretion Cognition Negative Regulation Of Mucus Secretion Positive Regulation Of Signal Transduction Regulation Of Secretion Establishment Of Protein Localization Postsynapse Negative Regulation Of Transport Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Nervous System Process System Process Learning Or Memory Membrane Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Vesicle-mediated Transport Regulation Of Locomotion Involved In Locomotory Behavior Positive Regulation Of Transport Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Biological Quality Regulation Of System Process Glutamatergic Synapse Heterotrimeric G-protein Binding Regulation Of Secretion By Cell Learning Nervous System Process Visual Learning Regulation Of Metal Ion Transport Regulation Of Mucus Secretion Negative Regulation Of Secretion Regulation Of Muscle Contraction Receptor-mediated Endocytosis Negative Regulation Of Inflammatory Response Negative Regulation Of Synaptic Transmission, Glutamatergic Visual Behavior Synaptic Membrane Cell Communication Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Receptor Internalization
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