GHSR and SIGMAR1

Number of citations of the paper that reports this interaction (PubMedID 29876881)
0

Data Source:
BioGRID (fluorescent resonance energy transfer)

		GHSR	SIGMAR1
Description		growth hormone secretagogue receptor	sigma non-opioid intracellular receptor 1
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GO Annotations	Cellular Component	Plasma Membrane Cell Surface Membrane Neuron Projection Membrane Raft Synaptic Membrane Schaffer Collateral - CA1 Synapse Postsynapse Glutamatergic Synapse	Nucleus Nuclear Envelope Nuclear Inner Membrane Nuclear Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Lipid Droplet Cytosol Plasma Membrane Postsynaptic Density Membrane Growth Cone Cytoplasmic Vesicle Cell Projection Synapse Postsynaptic Membrane Anchoring Junction Postsynapse Postsynaptic Density Membrane Glutamatergic Synapse
	Molecular Function	Growth Hormone Secretagogue Receptor Activity G Protein-coupled Receptor Activity Protein Binding Growth Hormone-releasing Hormone Receptor Activity Peptide Hormone Binding Hormone Binding Identical Protein Binding	G Protein-coupled Opioid Receptor Activity Protein Binding Signaling Receptor Activity Identical Protein Binding
	Biological Process	G Protein-coupled Receptor Internalization Signal Transduction G Protein-coupled Receptor Signaling Pathway Spermatogenesis Female Pregnancy Learning Or Memory Actin Polymerization Or Depolymerization Adult Feeding Behavior Response To Hormone Hormone-mediated Signaling Pathway Negative Regulation Of Norepinephrine Secretion Peptide Hormone Secretion Growth Hormone Secretion Response To Food Negative Regulation Of Appetite Positive Regulation Of Appetite Response To Follicle-stimulating Hormone Response To Estradiol Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Cellular Response To Insulin Stimulus Cellular Response To Hormone Stimulus Ghrelin Secretion Positive Regulation Of Multicellular Organism Growth Regulation Of Hindgut Contraction Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Fatty Acid Metabolic Process Positive Regulation Of Growth Negative Regulation Of Insulin Secretion Decidualization Insulin-like Growth Factor Receptor Signaling Pathway Negative Regulation Of Inflammatory Response Regulation Of Synapse Assembly Regulation Of Transmission Of Nerve Impulse Regulation Of Growth Hormone Secretion Regulation Of Feeding Behavior Response To Growth Hormone Cellular Response To Lipopolysaccharide Response To Dexamethasone Negative Regulation Of Locomotion Involved In Locomotory Behavior Cellular Response To Thyroid Hormone Stimulus Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Postsynaptic Modulation Of Chemical Synaptic Transmission Regulation Of Postsynapse Organization Positive Regulation Of Small Intestinal Transit Response To L-glutamate Positive Regulation Of Sprouting Angiogenesis Positive Regulation Of Eating Behavior Positive Regulation Of Small Intestine Smooth Muscle Contraction Regulation Of Gastric Motility Positive Regulation Of Vascular Endothelial Cell Proliferation Cellular Response To Insulin-like Growth Factor Stimulus Negative Regulation Of Macrophage Apoptotic Process	Lipid Transport Nervous System Development G Protein-coupled Opioid Receptor Signaling Pathway Regulation Of Neuron Apoptotic Process Protein Homotrimerization Regulation Of Postsynapse Assembly
Pathways		Peptide ligand-binding receptors G alpha (q) signalling events	Potential therapeutics for SARS
Drugs		Ulimorelin Macimorelin Echinacoside	Amitriptyline Remoxipride Haloperidol Dextromethorphan Nortriptyline Fenfluramine Pentazocine Naltrexone Cocaine Hydrocodone Sertraline Dimethyltryptamine Prasterone Phencyclidine Pimavanserin Noscapine Captodiame Pentoxyverine
Diseases
GWAS		Appendicular lean mass ( 33097823) Chronotype ( 30696823) Cocaine dependence ( 31212010) Height ( 20881960 23563607 25282103 25429064 31562340) Hip circumference adjusted for BMI ( 34021172) Metabolite levels ( 23823483)
Interacting Genes		5 interacting genes: CORT DRD1 GHRL LEAP2 SIGMAR1	5 interacting genes: ANK2 GHSR ITPR3 PDZD11 SRI
Entrez ID		2693	10280
HPRD ID		03541	03580
Ensembl ID		ENSG00000121853	ENSG00000147955
Uniprot IDs		Q92847	A0A7P0T9D5 A0A7P0Z4C2 B4DR71 Q99720
PDB IDs		6KO5 7F9Y 7F9Z 7NA7 7NA8 7W2Z 8JSR	5HK1 5HK2 6DJZ 6DK0 6DK1
Enriched GO Terms of Interacting Partners?		G Protein-coupled Receptor Signaling Pathway Hormone Activity G Protein-coupled Receptor Binding Habituation Conditioned Taste Aversion Dopamine Neurotransmitter Receptor Activity, Coupled Via Gs Operant Conditioning Sensitization G Protein-coupled Receptor Complex Synapse Assembly Glutamatergic Synapse Feeding Behavior Organic Hydroxy Compound Transport Adult Behavior Regulation Of Postsynapse Organization Regulation Of Synapse Assembly Positive Regulation Of Eating Behavior Positive Regulation Of Cortisol Secretion Ghrelin Receptor Binding Positive Regulation Of Response To Food Negative Regulation Of Circadian Sleep/wake Cycle, Sleep Regulation Of Circadian Sleep/wake Cycle, REM Sleep Positive Regulation Of Appetite Growth Hormone-releasing Hormone Activity Negative Regulation Of Circadian Sleep/wake Cycle, REM Sleep Cortisol Secretion Positive Regulation Of Small Intestinal Transit Positive Regulation Of Growth Rate Positive Regulation Of Small Intestine Smooth Muscle Contraction Regulation Of Gastric Motility Positive Regulation Of Bone Development Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Positive Regulation Of Growth Hormone Receptor Signaling Pathway Positive Regulation Of Gastric Mucosal Blood Circulation Synapse Dopamine Neurotransmitter Receptor Activity Neuronal Dense Core Vesicle Lumen Regulation Of Growth Rate Positive Regulation Of Gastro-intestinal System Smooth Muscle Contraction Regulation Of Locomotion Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Regulation Of Dopamine Uptake Involved In Synaptic Transmission Heterotrimeric G-protein Binding Interneuron Migration From The Subpallium To The Cortex Cell Junction Assembly Dopamine Binding Nonassociative Learning Phospholipase C-activating Dopamine Receptor Signaling Pathway Cerebral Cortex GABAergic Interneuron Migration Synapse Organization
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