GHSR and GHRL

Number of citations of the paper that reports this interaction (PubMedID 11227737)
0

Data Source:
HPRD (in vivo)

		GHSR	GHRL
Description		growth hormone secretagogue receptor	ghrelin and obestatin prepropeptide
Image
GO Annotations	Cellular Component	Plasma Membrane Cell Surface Membrane Neuron Projection Membrane Raft Synaptic Membrane Schaffer Collateral - CA1 Synapse Postsynapse Glutamatergic Synapse	Extracellular Region Extracellular Space Cytoplasm Endoplasmic Reticulum Lumen Axon Secretory Granule Lumen Schaffer Collateral - CA1 Synapse Postsynapse Glutamatergic Synapse Neuronal Dense Core Vesicle Lumen
	Molecular Function	Growth Hormone Secretagogue Receptor Activity G Protein-coupled Receptor Activity Protein Binding Growth Hormone-releasing Hormone Receptor Activity Peptide Hormone Binding Hormone Binding Identical Protein Binding	G Protein-coupled Receptor Binding Hormone Activity Protein Binding Growth Hormone-releasing Hormone Activity Protein Tyrosine Kinase Activator Activity Ghrelin Receptor Binding
	Biological Process	G Protein-coupled Receptor Internalization Signal Transduction G Protein-coupled Receptor Signaling Pathway Spermatogenesis Female Pregnancy Learning Or Memory Actin Polymerization Or Depolymerization Adult Feeding Behavior Response To Hormone Hormone-mediated Signaling Pathway Negative Regulation Of Norepinephrine Secretion Peptide Hormone Secretion Growth Hormone Secretion Response To Food Negative Regulation Of Appetite Positive Regulation Of Appetite Response To Follicle-stimulating Hormone Response To Estradiol Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Cellular Response To Insulin Stimulus Cellular Response To Hormone Stimulus Ghrelin Secretion Positive Regulation Of Multicellular Organism Growth Regulation Of Hindgut Contraction Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Fatty Acid Metabolic Process Positive Regulation Of Growth Negative Regulation Of Insulin Secretion Decidualization Insulin-like Growth Factor Receptor Signaling Pathway Negative Regulation Of Inflammatory Response Regulation Of Synapse Assembly Regulation Of Transmission Of Nerve Impulse Regulation Of Growth Hormone Secretion Regulation Of Feeding Behavior Response To Growth Hormone Cellular Response To Lipopolysaccharide Response To Dexamethasone Negative Regulation Of Locomotion Involved In Locomotory Behavior Cellular Response To Thyroid Hormone Stimulus Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Postsynaptic Modulation Of Chemical Synaptic Transmission Regulation Of Postsynapse Organization Positive Regulation Of Small Intestinal Transit Response To L-glutamate Positive Regulation Of Sprouting Angiogenesis Positive Regulation Of Eating Behavior Positive Regulation Of Small Intestine Smooth Muscle Contraction Regulation Of Gastric Motility Positive Regulation Of Vascular Endothelial Cell Proliferation Cellular Response To Insulin-like Growth Factor Stimulus Negative Regulation Of Macrophage Apoptotic Process	Gastric Acid Secretion Negative Regulation Of Endothelial Cell Proliferation G Protein-coupled Receptor Internalization Glucose Metabolic Process G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Synapse Assembly Actin Polymerization Or Depolymerization Adult Feeding Behavior Response To Hormone Hormone-mediated Signaling Pathway Dendrite Development Negative Regulation Of Angiogenesis Growth Hormone Secretion Response To Nutrient Levels Positive Regulation Of Insulin Secretion Regulation Of Response To Food Positive Regulation Of Response To Food Positive Regulation Of Appetite Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Positive Regulation Of Growth Rate Negative Regulation Of Locomotion Positive Regulation Of Multicellular Organism Growth Regulation Of Cell Population Proliferation Negative Regulation Of Circadian Sleep/wake Cycle, REM Sleep Negative Regulation Of Apoptotic Process Cortisol Secretion Positive Regulation Of MAPK Cascade Response To Estrogen Positive Regulation Of Growth Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Negative Regulation Of Insulin Secretion Decidualization Negative Regulation Of Inflammatory Response Cartilage Development Positive Regulation Of Corticotropin Secretion Positive Regulation Of Cortisol Secretion Response To Electrical Stimulus Positive Regulation Of Synapse Assembly Regulation Of Transmission Of Nerve Impulse Excitatory Postsynaptic Potential Positive Regulation Of Growth Hormone Secretion Positive Regulation Of Growth Hormone Receptor Signaling Pathway Postsynaptic Modulation Of Chemical Synaptic Transmission Regulation Of Postsynapse Organization Positive Regulation Of Small Intestinal Transit Positive Regulation Of Cold-induced Thermogenesis Positive Regulation Of Bone Development Positive Regulation Of Sprouting Angiogenesis Positive Regulation Of Eating Behavior Positive Regulation Of Adipose Tissue Development Positive Regulation Of Gastro-intestinal System Smooth Muscle Contraction Positive Regulation Of Gastric Mucosal Blood Circulation Positive Regulation Of Small Intestine Smooth Muscle Contraction Regulation Of Gastric Motility Positive Regulation Of Vascular Endothelial Cell Proliferation Positive Regulation Of Feeding Behavior
Pathways		Peptide ligand-binding receptors G alpha (q) signalling events
Drugs		Ulimorelin Macimorelin Echinacoside
Diseases
GWAS		Appendicular lean mass ( 33097823) Chronotype ( 30696823) Cocaine dependence ( 31212010) Height ( 20881960 23563607 25282103 25429064 31562340) Hip circumference adjusted for BMI ( 34021172) Metabolite levels ( 23823483)	Autism spectrum disorder or schizophrenia ( 28540026) ghrelin levels ( 33852427)
Interacting Genes		5 interacting genes: CORT DRD1 GHRL LEAP2 SIGMAR1	9 interacting genes: ACE2 AGRP GHRHR GHSR LEP MLNR NPY UBQLN1 UBQLN2
Entrez ID		2693	51738
HPRD ID		03541	05638
Ensembl ID		ENSG00000121853	ENSG00000157017
Uniprot IDs		Q92847	Q9UBU3
PDB IDs		6KO5 7F9Y 7F9Z 7NA7 7NA8 7W2Z 8JSR	6H3E 7F9Y 7NA7 7W2Z
Enriched GO Terms of Interacting Partners?		G Protein-coupled Receptor Signaling Pathway Hormone Activity G Protein-coupled Receptor Binding Habituation Conditioned Taste Aversion Dopamine Neurotransmitter Receptor Activity, Coupled Via Gs Operant Conditioning Sensitization G Protein-coupled Receptor Complex Synapse Assembly Glutamatergic Synapse Feeding Behavior Organic Hydroxy Compound Transport Adult Behavior Regulation Of Postsynapse Organization Regulation Of Synapse Assembly Positive Regulation Of Eating Behavior Positive Regulation Of Cortisol Secretion Ghrelin Receptor Binding Positive Regulation Of Response To Food Negative Regulation Of Circadian Sleep/wake Cycle, Sleep Regulation Of Circadian Sleep/wake Cycle, REM Sleep Positive Regulation Of Appetite Growth Hormone-releasing Hormone Activity Negative Regulation Of Circadian Sleep/wake Cycle, REM Sleep Cortisol Secretion Positive Regulation Of Small Intestinal Transit Positive Regulation Of Growth Rate Positive Regulation Of Small Intestine Smooth Muscle Contraction Regulation Of Gastric Motility Positive Regulation Of Bone Development Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Positive Regulation Of Growth Hormone Receptor Signaling Pathway Positive Regulation Of Gastric Mucosal Blood Circulation Synapse Dopamine Neurotransmitter Receptor Activity Neuronal Dense Core Vesicle Lumen Regulation Of Growth Rate Positive Regulation Of Gastro-intestinal System Smooth Muscle Contraction Regulation Of Locomotion Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Regulation Of Dopamine Uptake Involved In Synaptic Transmission Heterotrimeric G-protein Binding Interneuron Migration From The Subpallium To The Cortex Cell Junction Assembly Dopamine Binding Nonassociative Learning Phospholipase C-activating Dopamine Receptor Signaling Pathway Cerebral Cortex GABAergic Interneuron Migration Synapse Organization	Adult Feeding Behavior Feeding Behavior Positive Regulation Of Behavior Positive Regulation Of Feeding Behavior Regulation Of Behavior Regulation Of Response To Food Regulation Of Appetite Regulation Of Feeding Behavior Growth Hormone-releasing Hormone Receptor Activity Regulation Of Response To Nutrient Levels Adult Behavior Positive Regulation Of Eating Behavior Positive Regulation Of Response To Food Positive Regulation Of Appetite Response To Insulin Growth Hormone Secretion Regulation Of Eating Behavior Peptide Hormone Secretion Regulation Of Transport Peptide Secretion Regulation Of Amine Transport Hormone Secretion Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Negative Regulation Of Appetite Response To Peptide Hormone Regulation Of Growth Hormone Secretion Cellular Response To Insulin Stimulus Peptide Transport Hormone Transport Hormone Binding Positive Regulation Of ERAD Pathway G Protein-coupled Receptor Activity G Protein-coupled Receptor Signaling Pathway Amide Transport Regulation Of Defense Response Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Negative Regulation Of Transport Regulation Of ERAD Pathway Signal Release Positive Regulation Of Developmental Growth Photoperiodism Regulation Of Blood Pressure Neuropeptide Hormone Activity Cellular Response To Peptide Hormone Stimulus Eating Behavior Maternal Process Involved In Female Pregnancy Positive Regulation Of Multicellular Organism Growth Hormone Metabolic Process Determination Of Adult Lifespan Positive Regulation Of Multicellular Organismal Process
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?