CYB5R1 and CYCS

Number of citations of the paper that reports this interaction (PubMedID 9760250)
0

Data Source:
HPRD (in vitro)

		CYB5R1	CYCS
Description		cytochrome b5 reductase 1	cytochrome c, somatic
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Membrane Platelet Alpha Granule Membrane Extracellular Exosome	Nucleus Mitochondrion Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Cytosol Apoptosome
	Molecular Function	Cytochrome-b5 Reductase Activity, Acting On NAD(P)H Protein Binding Oxidoreductase Activity FAD Binding	Protein Binding Electron Transfer Activity Heme Binding Metal Ion Binding
	Biological Process	Lipid Metabolic Process Steroid Biosynthetic Process Steroid Metabolic Process Bicarbonate Transport Sterol Biosynthetic Process	Mitochondrial Electron Transport, Ubiquinol To Cytochrome C Mitochondrial Electron Transport, Cytochrome C To Oxygen Apoptotic Process Cellular Respiration Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Execution Phase Of Apoptosis
Pathways		Platelet degranulation Erythrocytes take up carbon dioxide and release oxygen	Release of apoptotic factors from the mitochondria Formation of apoptosome Activation of caspases through apoptosome-mediated cleavage SMAC (DIABLO) binds to IAPs SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes Transcriptional activation of mitochondrial biogenesis Detoxification of Reactive Oxygen Species Pyroptosis TP53 Regulates Metabolic Genes Respiratory electron transport Regulation of the apoptosome activity Regulation of the apoptosome activity Cytoprotection by HMOX1
Drugs		Flavin adenine dinucleotide	Minocycline Protoporphyrin Ix Containing Co Ferroheme C Imidazole Zinc protoporphyrin Trimethyllysine Zinc Substituted Heme C Artenimol
Diseases			Thrombocytopenia (THC); Familial platelet disorder with associated myeloid malignancy (FPDMM)
GWAS			Alzheimer's disease (cognitive decline) ( 23535033) High density lipoprotein cholesterol levels ( 30498476) Systemic lupus erythematosus ( 19838195)
Interacting Genes		8 interacting genes: CYCS HIGD1C SGTA SGTB SLC51B TTC1 UBQLN1 UBQLN4	22 interacting genes: AGTPBP1 APAF1 BCL2 BCL2L1 CASP9 COX4I2 CUL9 CYB5A CYB5R1 CYB5R3 CYC1 FDX1 HSPA8 HSPB1 KRT40 MEOX2 NDOR1 RNF7 SAFB SNCA UQCRC1 VDAC2
Entrez ID		51706	54205
HPRD ID		06434	00479
Ensembl ID		ENSG00000159348	ENSG00000172115
Uniprot IDs		Q9UHQ9	G4XXL9 P99999
PDB IDs			1J3S 2N3Y 2N9I 2N9J 3NWV 3ZCF 3ZOO 5EXQ 5O10 5TY3 6DUJ 6ECJ 6XNK
Enriched GO Terms of Interacting Partners?		TRC Complex Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Positive Regulation Of ERAD Pathway Regulation Of ERAD Pathway Establishment Of Protein Localization To Endoplasmic Reticulum Regulation Of Proteasomal Protein Catabolic Process Protein Targeting To ER Positive Regulation Of Response To Endoplasmic Reticulum Stress Polyubiquitin Modification-dependent Protein Binding Protein Targeting To Membrane Negative Regulation Of Store-operated Calcium Channel Activity Regulation Of Protein Catabolic Process Regulation Of Proteolysis Autophagosome Regulation Of Response To Endoplasmic Reticulum Stress ERAD Pathway Nuclear Proteasome Complex Positive Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Apoptosome Negative Regulation Of Autophagosome Maturation Regulation Of Cellular Response To Stress Positive Regulation Of Proteolysis Involved In Protein Catabolic Process BAT3 Complex Binding Positive Regulation Of Protein Glycosylation Cytosolic Proteasome Complex Regulation Of Ubiquitin-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Molecular Adaptor Activity Negative Regulation Of ERAD Pathway Regulation Of Protein Metabolic Process Bile Acid Secretion Regulation Of Protein Glycosylation Regulation Of Macroautophagy Positive Regulation Of Proteolysis Establishment Of Protein Localization To Membrane Protein Targeting Positive Regulation Of Protein Catabolic Process Protein-containing Complex Bile Acid Transmembrane Transporter Activity Mitochondrial Electron Transport, Ubiquinol To Cytochrome C K48-linked Polyubiquitin Modification-dependent Protein Binding Positive Regulation Of Protein Exit From Endoplasmic Reticulum Mitochondrial Respirasome Assembly Positive Regulation Of Protein Metabolic Process Response To Endoplasmic Reticulum Stress Identical Protein Binding Regulation Of Toll-like Receptor 3 Signaling Pathway Aggrephagy Response To Stress	Electron Transport Chain Mitochondrial Outer Membrane Mitochondrion Neuron Apoptotic Process Generation Of Precursor Metabolites And Energy Mitochondrial Membrane Apoptosome Dendritic Cell Apoptotic Process Respiratory Electron Transport Chain Mitochondrial Membrane Organization Mitochondrion Organization Quinol-cytochrome-c Reductase Activity FAD Binding BH3 Domain Binding Cytochrome-b5 Reductase Activity, Acting On NAD(P)H Epithelial Cell Apoptotic Process Leukocyte Apoptotic Process Negative Regulation Of Dendritic Cell Apoptotic Process Regulation Of Mitochondrial Membrane Permeability Bcl-2 Family Protein Complex Electron Transfer Activity Intrinsic Apoptotic Signaling Pathway Respiratory Chain Complex III Mitochondrial Electron Transport, Ubiquinol To Cytochrome C Apoptotic Mitochondrial Changes Regulation Of Membrane Permeability Pore Complex Aerobic Electron Transport Chain Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Steroid Biosynthetic Process Mitochondrial Inner Membrane Response To Alkaloid Platelet Alpha Granule Membrane Aerobic Respiration Negative Regulation Of Anoikis Regulation Of Neuron Apoptotic Process Negative Regulation Of Autophagy Programmed Cell Death Involved In Cell Development Cellular Respiration Oxidative Phosphorylation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Release Of Cytochrome C From Mitochondria Cytosol Positive Regulation Of Apoptotic Process Regulation Of Anoikis Ubiquitin Protein Ligase Binding Sterol Metabolic Process Protein Refolding Positive Regulation Of Programmed Cell Death Apoptotic Signaling Pathway
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