CYB5R1 and SLC51B

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CYB5R1	SLC51B
Description		cytochrome b5 reductase 1	SLC51 subunit beta
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Mitochondrion Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Membrane Platelet Alpha Granule Membrane Extracellular Exosome	Plasma Membrane Membrane Basolateral Plasma Membrane Protein-containing Complex
	Molecular Function	Cytochrome-b5 Reductase Activity, Acting On NAD(P)H Protein Binding Oxidoreductase Activity FAD Binding	Protein Binding Bile Acid Transmembrane Transporter Activity Transmembrane Transporter Activity Protein Heterodimerization Activity
	Biological Process	Lipid Metabolic Process Steroid Biosynthetic Process Steroid Metabolic Process Bicarbonate Transport Sterol Biosynthetic Process	Lipid Transport Bile Acid And Bile Salt Transport Regulation Of Protein Stability Bile Acid Secretion Transmembrane Transport Positive Regulation Of Protein Glycosylation Positive Regulation Of Protein Exit From Endoplasmic Reticulum Positive Regulation Of Protein Targeting To Membrane
Pathways		Platelet degranulation Erythrocytes take up carbon dioxide and release oxygen	Recycling of bile acids and salts
Drugs		Flavin adenine dinucleotide
Diseases
GWAS			White matter hyperintensities ( 32358547)
Interacting Genes		8 interacting genes: CYCS HIGD1C SGTA SGTB SLC51B TTC1 UBQLN1 UBQLN4	4 interacting genes: ASPH CYB5R1 ETNK1 LAT
Entrez ID		51706	123264
HPRD ID		06434	17811
Ensembl ID		ENSG00000159348	ENSG00000186198
Uniprot IDs		Q9UHQ9	Q86UW2
PDB IDs
Enriched GO Terms of Interacting Partners?		TRC Complex Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Positive Regulation Of ERAD Pathway Regulation Of ERAD Pathway Establishment Of Protein Localization To Endoplasmic Reticulum Regulation Of Proteasomal Protein Catabolic Process Protein Targeting To ER Positive Regulation Of Response To Endoplasmic Reticulum Stress Polyubiquitin Modification-dependent Protein Binding Protein Targeting To Membrane Negative Regulation Of Store-operated Calcium Channel Activity Regulation Of Protein Catabolic Process Regulation Of Proteolysis Autophagosome Regulation Of Response To Endoplasmic Reticulum Stress ERAD Pathway Nuclear Proteasome Complex Positive Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Apoptosome Negative Regulation Of Autophagosome Maturation Regulation Of Cellular Response To Stress Positive Regulation Of Proteolysis Involved In Protein Catabolic Process BAT3 Complex Binding Positive Regulation Of Protein Glycosylation Cytosolic Proteasome Complex Regulation Of Ubiquitin-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Molecular Adaptor Activity Negative Regulation Of ERAD Pathway Regulation Of Protein Metabolic Process Bile Acid Secretion Regulation Of Protein Glycosylation Regulation Of Macroautophagy Positive Regulation Of Proteolysis Establishment Of Protein Localization To Membrane Protein Targeting Positive Regulation Of Protein Catabolic Process Protein-containing Complex Bile Acid Transmembrane Transporter Activity Mitochondrial Electron Transport, Ubiquinol To Cytochrome C K48-linked Polyubiquitin Modification-dependent Protein Binding Positive Regulation Of Protein Exit From Endoplasmic Reticulum Mitochondrial Respirasome Assembly Positive Regulation Of Protein Metabolic Process Response To Endoplasmic Reticulum Stress Identical Protein Binding Regulation Of Toll-like Receptor 3 Signaling Pathway Aggrephagy Response To Stress	Peptidyl-aspartic Acid 3-dioxygenase Activity Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Calcium-mediated Signaling TCR Signalosome Ethanolamine Kinase Activity Activation Of Store-operated Calcium Channel Activity Positive Regulation Of Store-operated Calcium Channel Activity Sarcoplasmic Reticulum Lumen Junctional Sarcoplasmic Reticulum Membrane Cortical Endoplasmic Reticulum Membrane Raft Distribution Membrane Raft Localization Cytochrome-b5 Reductase Activity, Acting On NAD(P)H Phosphatidylethanolamine Biosynthetic Process
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