ITGB3 and TNS2

Number of citations of the paper that reports this interaction (PMID 12606711)
66

Data Source:
HPRD (in vitro)

		ITGB3	TNS2
Gene Name		integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)	tensin 2
Image
Gene Ontology Annotations	Cellular Component	Nucleus Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Integrin Complex Cell Surface Platelet Alpha Granule Membrane Lamellipodium Membrane Filopodium Membrane Microvillus Membrane Ruffle Membrane Integrin Alphav-beta3 Complex Melanosome Receptor Complex Extracellular Vesicular Exosome Alphav-beta3 Integrin-vitronectin Complex	Plasma Membrane Focal Adhesion
	Molecular Function	Fibronectin Binding Protease Binding Protein Disulfide Isomerase Activity Receptor Activity Platelet-derived Growth Factor Receptor Binding Protein Binding Identical Protein Binding Vascular Endothelial Growth Factor Receptor 2 Binding Cell Adhesion Molecule Binding Extracellular Matrix Binding	Phosphoprotein Phosphatase Activity Protein Binding Metal Ion Binding
	Biological Process	Positive Regulation Of Protein Phosphorylation Positive Regulation Of Endothelial Cell Proliferation Platelet Degranulation Protein Folding Cell-substrate Junction Assembly Cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Axon Guidance Blood Coagulation Positive Regulation Of Endothelial Cell Migration Negative Regulation Of Macrophage Derived Foam Cell Differentiation Negative Regulation Of Lipid Storage Smooth Muscle Cell Migration Cell Growth Cell Migration Platelet Activation Extracellular Matrix Organization Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell-substrate Adhesion Activation Of Protein Kinase Activity Negative Regulation Of Lipid Transport Heterotypic Cell-cell Adhesion Substrate Adhesion-dependent Cell Spreading Tube Development Apolipoprotein A-I-mediated Signaling Pathway Wound Healing Regulation Of Bone Resorption Negative Regulation Of Low-density Lipoprotein Particle Receptor Biosynthetic Process Viral Entry Into Host Cell Vascular Endothelial Growth Factor Receptor Signaling Pathway Mesodermal Cell Differentiation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Negative Regulation Of Lipoprotein Metabolic Process Leukocyte Migration Negative Chemotaxis Angiogenesis Involved In Wound Healing Platelet Aggregation	Kidney Development Negative Regulation Of Cell Proliferation Response To Muscle Activity Dephosphorylation Cellular Homeostasis Collagen Metabolic Process Multicellular Organism Growth Intracellular Signal Transduction Multicellular Organismal Homeostasis
Pathways		Signal transduction by L1 Axon guidance Elastic fibre formation p130Cas linkage to MAPK signaling for integrins Integrin alphaIIb beta3 signaling L1CAM interactions Platelet degranulation Non-integrin membrane-ECM interactions GRB2:SOS provides linkage to MAPK signaling for Integrins Platelet Aggregation (Plug Formation) VEGFA-VEGFR2 Pathway Cell surface interactions at the vascular wall PECAM1 interactions Molecules associated with elastic fibres Syndecan interactions Signaling by VEGF Response to elevated platelet cytosolic Ca2+ ECM proteoglycans Integrin cell surface interactions Platelet activation, signaling and aggregation
Drugs		Abciximab Eptifibatide Antithymocyte globulin Tirofiban
Diseases
GWAS
Protein-Protein Interactions		40 interactors: AKT1 ANGPTL3 CAPN1 CD36 CIB1 COL1A2 DAB1 DAB2 DOK1 EPS8 FBLN2 FGA FGG FLNA FLNB FN1 ILK ITGA2B ITGA5 ITGAV ITGB3BP KDR NID1 NUMB P2RY2 PDGFRA PDGFRB PDPK1 PECAM1 PTK2 PTK2B PXN SHC1 SRC TGM2 THBS1 THY1 TLN1 TNS2 VTN	28 interactors: AXL BRCA1 C11orf87 C19orf66 CRKL CSNK1E ERBB2 ERBB3 FGFR1 GFI1B ITGB3 ITGB5 ITGB7 KIF1A KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP12-2 NUBP2 PKP1 REEP6 REL TBC1D16 TEKT5 ZNF250 ZNF417 ZNF587
Entrez ID		3690	23371
HPRD ID		01428	16256
Ensembl ID		ENSG00000259207	ENSG00000111077
Uniprot IDs		P05106	Q63HR2
PDB IDs		1JV2 1KUP 1KUZ 1L5G 1M1X 1M8O 1MIZ 1MK7 1MK9 1RN0 1S4X 1TYE 1U8C 2INI 2K9J 2KNC 2KV9 2L1C 2L91 2LJD 2LJE 2LJF 2Q6W 2RMZ 2RN0 2VC2 2VDK 2VDL 2VDM 2VDN 2VDO 2VDP 2VDQ 2VDR 3FCS 3FCU 3IJE 3NID 3NIF 3NIG 3T3M 3T3P 3ZDX 3ZDY 3ZDZ 3ZE0 3ZE1 3ZE2 4G1E 4G1M	2DKQ 2KNO 2L6K 2LOZ 3HQC
Enriched GO Terms of Interacting Partners?		Platelet Activation Positive Regulation Of Cell Adhesion Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Regulation Of Cell Adhesion Blood Coagulation Positive Regulation Of Cellular Component Movement Cell Adhesion Hemostasis Positive Regulation Of Locomotion Regulation Of Cell Migration Wound Healing Positive Regulation Of Phosphorylation Regulation Of Cell-substrate Adhesion Regulation Of Cell Motility Cell-substrate Adhesion Extracellular Matrix Organization Extracellular Structure Organization Positive Regulation Of Cell-substrate Adhesion Regulation Of Locomotion Regulation Of Cellular Component Movement Response To Wounding Regulation Of Body Fluid Levels Regulation Of Phosphorylation Cell-matrix Adhesion Positive Regulation Of Protein Phosphorylation Positive Regulation Of Signal Transduction Regulation Of Phosphorus Metabolic Process Cell Activation Blood Vessel Development Positive Regulation Of Protein Modification Process Signal Transduction Regulation Of Protein Phosphorylation Vasculature Development Regulation Of Cellular Component Organization Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Signaling Positive Regulation Of Protein Metabolic Process Cell Communication Positive Regulation Of Kinase Activity Locomotion Anatomical Structure Morphogenesis Regulation Of Protein Metabolic Process Movement Of Cell Or Subcellular Component Regulation Of Signaling Regulation Of Intracellular Signal Transduction Platelet Degranulation	Immune System Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Substrate Adhesion-dependent Cell Spreading Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Cell-substrate Adhesion Regulation Of Signal Transduction Neurotrophin TRK Receptor Signaling Pathway Regulation Of Protein Metabolic Process Neurotrophin Signaling Pathway Positive Regulation Of Protein Kinase Activity Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Kinase Activity Regulation Of Signaling Positive Regulation Of Protein Modification Process Peptidyl-tyrosine Phosphorylation Positive Regulation Of Transferase Activity Cellular Response To Growth Factor Stimulus Regulation Of Cellular Protein Metabolic Process Response To Growth Factor Regulation Of Histone H3-K4 Methylation Integrin-mediated Signaling Pathway Regulation Of Transcription From RNA Polymerase III Promoter Heterotypic Cell-cell Adhesion Phosphatidylinositol 3-kinase Signaling Regulation Of Cellular Process Phosphatidylinositol-mediated Signaling Signal Transduction Cell Morphogenesis Involved In Differentiation Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Fibroblast Growth Factor Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Cell-matrix Adhesion Regulation Of Intracellular Signal Transduction Regulation Of Kinase Activity Innate Immune Response Cell Surface Receptor Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Signaling Multicellular Organismal Development Intracellular Signal Transduction Cellular Response To Organic Substance Viral Entry Into Host Cell Positive Regulation Of Phosphorylation Response To Organic Substance
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