ITGB3 and PDGFRA

Number of citations of the paper that reports this interaction (PubMedID 11953315)
66

Data Source:
HPRD (in vitro, in vivo)

		ITGB3	PDGFRA
Description		integrin subunit beta 3	platelet derived growth factor receptor alpha
Image
GO Annotations	Cellular Component	Ruffle Nucleus Nucleoplasm Plasma Membrane Cell-cell Junction Focal Adhesion Integrin Complex External Side Of Plasma Membrane Cell Surface Membrane Apical Plasma Membrane Filopodium Platelet Alpha Granule Membrane Lamellipodium Membrane Filopodium Membrane Microvillus Membrane Ruffle Membrane Protein-containing Complex Integrin Alphav-beta3 Complex Alphav-beta3 Integrin-PKCalpha Complex Alphav-beta3 Integrin-IGF-1-IGF1R Complex Alphav-beta3 Integrin-HMGB1 Complex Melanosome Cell Projection Receptor Complex Synapse Postsynaptic Membrane Extracellular Exosome Anchoring Junction Integrin AlphaIIb-beta3 Complex Alphav-beta3 Integrin-vitronectin Complex Alpha9-beta1 Integrin-ADAM8 Complex Synaptic Membrane Glycinergic Synapse Glutamatergic Synapse	Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Plasma Membrane Microvillus Cilium External Side Of Plasma Membrane Cell Surface Membrane Nuclear Body Cell Junction Protein-containing Complex Cell Projection Receptor Complex Platelet-derived Growth Factor Receptor-ligand Complex
	Molecular Function	Virus Receptor Activity Fibronectin Binding Protease Binding Protein Disulfide Isomerase Activity Protein Kinase C Binding Platelet-derived Growth Factor Receptor Binding Integrin Binding Protein Binding Coreceptor Activity Fibroblast Growth Factor Binding Enzyme Binding C-X3-C Chemokine Binding Insulin-like Growth Factor I Binding Neuregulin Binding Identical Protein Binding Vascular Endothelial Growth Factor Receptor 2 Binding Metal Ion Binding Cell Adhesion Molecule Binding Extracellular Matrix Binding Fibrinogen Binding	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Platelet-derived Growth Factor Alpha-receptor Activity Vascular Endothelial Growth Factor Receptor Activity Platelet-derived Growth Factor Receptor Binding Protein Binding ATP Binding Kinase Activity Transferase Activity Vascular Endothelial Growth Factor Binding Protein Homodimerization Activity Protein-containing Complex Binding Platelet-derived Growth Factor Binding Phospholipase C Activator Activity
	Biological Process	Angiogenesis Positive Regulation Of Endothelial Cell Proliferation Positive Regulation Of Cell-matrix Adhesion Positive Regulation Of Leukocyte Migration Cell-substrate Junction Assembly Cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Embryo Implantation Blood Coagulation Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Gene Expression Negative Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Fibroblast Migration Negative Regulation Of Lipid Storage Negative Regulation Of Low-density Lipoprotein Particle Clearance Response To Activity Smooth Muscle Cell Migration Positive Regulation Of Smooth Muscle Cell Migration Cell Migration Platelet Activation Positive Regulation Of Cell Migration Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell-substrate Adhesion Negative Regulation Of Lipid Transport Regulation Of Protein Localization Regulation Of Actin Cytoskeleton Organization Cell Adhesion Mediated By Integrin Positive Regulation Of Cell Adhesion Mediated By Integrin Positive Regulation Of Osteoblast Proliferation Heterotypic Cell-cell Adhesion Substrate Adhesion-dependent Cell Spreading Tube Development Wound Healing, Spreading Of Epidermal Cells Response To Platelet-derived Growth Factor Cellular Response To Platelet-derived Growth Factor Stimulus Apolipoprotein A-I-mediated Signaling Pathway Wound Healing Apoptotic Cell Clearance Regulation Of Bone Resorption Positive Regulation Of Angiogenesis Positive Regulation Of Bone Resorption Symbiont Entry Into Host Cell Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Fibroblast Proliferation Mesodermal Cell Differentiation Positive Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Lipoprotein Metabolic Process Regulation Of Developmental Process Negative Chemotaxis Regulation Of Transport Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Serotonin Uptake Angiogenesis Involved In Wound Healing Regulation Of Biological Quality Positive Regulation Of ERK1 And ERK2 Cascade Platelet Aggregation Cellular Response To Mechanical Stimulus Cellular Response To Xenobiotic Stimulus Positive Regulation Of Glomerular Mesangial Cell Proliferation Blood Coagulation, Fibrin Clot Formation Maintenance Of Postsynaptic Specialization Structure Regulation Of Postsynaptic Neurotransmitter Receptor Internalization Regulation Of Postsynaptic Neurotransmitter Receptor Diffusion Trapping Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Adenylate Cyclase-inhibiting Opioid Receptor Signaling Pathway Positive Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Regulation Of Trophoblast Cell Migration Regulation Of Extracellular Matrix Organization Cellular Response To Insulin-like Growth Factor Stimulus Negative Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of T Cell Migration	Luteinization In Utero Embryonic Development Cell Activation Hematopoietic Progenitor Cell Differentiation Chemotaxis Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Estrogen Metabolic Process Positive Regulation Of Cell Population Proliferation Female Gonad Development Anatomical Structure Morphogenesis Animal Organ Morphogenesis Negative Regulation Of Platelet Activation Cell Migration Peptidyl-tyrosine Phosphorylation Signal Transduction Involved In Regulation Of Gene Expression Extracellular Matrix Organization Lung Development Adrenal Gland Development Positive Regulation Of Cell Migration Male Genitalia Development Regulation Of Actin Cytoskeleton Organization Leydig Cell Differentiation Cellular Response To Reactive Oxygen Species Platelet-derived Growth Factor Receptor-alpha Signaling Pathway Positive Regulation Of Cell Proliferation By VEGF-activated Platelet Derived Growth Factor Receptor Signaling Pathway Wound Healing Odontogenesis Of Dentin-containing Tooth Protein Autophosphorylation Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Fibroblast Proliferation Embryonic Digestive Tract Morphogenesis Embryonic Cranial Skeleton Morphogenesis Embryonic Skeletal System Morphogenesis Skeletal System Morphogenesis Positive Regulation Of Calcium-mediated Signaling White Fat Cell Differentiation Positive Regulation Of Chemotaxis Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cardiac Myofibril Assembly Roof Of Mouth Development Face Morphogenesis Cell Chemotaxis Retina Vasculature Development In Camera-type Eye Positive Regulation Of ERK1 And ERK2 Cascade Platelet Aggregation Cellular Response To Amino Acid Stimulus Metanephric Glomerular Capillary Formation Regulation Of Mesenchymal Stem Cell Differentiation
Pathways		Platelet degranulation Elastic fibre formation PECAM1 interactions Molecules associated with elastic fibres Integrin cell surface interactions Integrin cell surface interactions TGF-beta receptor signaling activates SMADs Syndecan interactions Syndecan interactions ECM proteoglycans Integrin signaling GRB2:SOS provides linkage to MAPK signaling for Integrins p130Cas linkage to MAPK signaling for integrins VEGFA-VEGFR2 Pathway Signal transduction by L1 MAP2K and MAPK activation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants Signaling by RAF1 mutants Mechanical load activates signaling by PIEZO1 and integrins in osteocytes Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	PIP3 activates AKT signaling Downstream signal transduction Signaling by PDGF Constitutive Signaling by Aberrant PI3K in Cancer RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants Signaling by PDGFRA extracellular domain mutants Imatinib-resistant PDGFR mutants Sunitinib-resistant PDGFR mutants Regorafenib-resistant PDGFR mutants Sorafenib-resistant PDGFR mutants PDGFR mutants bind TKIs
Drugs		Abciximab Eptifibatide Antithymocyte immunoglobulin (rabbit) Levothyroxine Tirofiban Resveratrol Lefradafiban LM-609 Fradafiban Ferric maltol	Becaplermin Imatinib Sunitinib XL820 Olaratumab Pazopanib Midostaurin Regorafenib Ponatinib Lenvatinib Nintedanib Foreskin keratinocyte (neonatal) Tivozanib Fostamatinib Erdafitinib Amuvatinib Ripretinib
Diseases		Allograft rejection Glanzmann thrombasthenia	Glioma
GWAS		Body mass index ( 25673413) Brain morphology (MOSTest) ( 32665545) Chromosomal aberration frequency (chromosome type) in genotoxic compound exposure ( 31586183) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Height ( 33713608) High chromosomal aberration frequency (chromosome type) ( 31586183) Hip circumference adjusted for BMI ( 34021172) Mean platelet volume ( 27863252) Medication use (thyroid preparations) ( 31015401) Very long-chain saturated fatty acid levels (fatty acid 20:0) ( 25378659)	Adult asthma ( 27611488) Asthma ( 27611488) Blood protein levels ( 30072576) Cadmium levels ( 26025379) Core binding factor acute myeloid leukemia ( 27903959) Corneal astigmatism ( 29422769 22144915) Corneal curvature ( 24963161 23401653 21665993) Height ( 18193045) Hematocrit ( 29403010) Hemoglobin ( 29403010) Lupus nephritis in systemic lupus erythematosus ( 24925725) Macular thickness ( 30535121) Mean corpuscular hemoglobin ( 20139978 29403010) Mean corpuscular volume ( 29403010 20139978) Platelet count ( 29403010) Post bronchodilator FEV1/FVC ratio ( 26634245) Pulse pressure ( 30578418) Red blood cell count ( 28453575 29403010 20139978) Serum VEGFR2 concentration ( 25411163) Systolic blood pressure ( 30578418) Uterine fibroids ( 30194396 31649266) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		50 interacting genes: AKT1 ANGPTL3 APP CAPN1 CD36 CDK1 COL1A2 DAB1 DAB2 DOK1 EPS8 FBLN2 FGA FGFR1 FGG FLNA FLNB FN1 GRIA2 HRAS ILK ITGA2B ITGA5 ITGAV ITGB3BP KDR MAPK3 MIIP NID1 NUMB P2RY2 P4HB PDGFRA PDGFRB PDK1 PDPK1 PECAM1 PLA2G2A PLA2G4A PTK2 PTK2B PXN SHC1 SRC TGM2 THBS1 THY1 TLN1 TNS2 VTN	62 interacting genes: AKT1 ARNT AURKA BECN1 CAV1 CAV3 CBL CCND2 CD44 CDK4 CDK6 CDKN2A CDKN2B CDKN2C CRK CRKL EGFR ERBB2 ERBB3 FBXO25 FZR1 GRB14 GRM1 HGF ITGAV ITGB3 JAK1 KASH5 KDELR2 LATS2 MAP2K5 MYC NF2 NHERF1 PDGFA PDGFB PDGFC PDGFRB PIK3CA PIK3R1 PLCG1 PLPP6 PRMT5 PTPN11 RAF1 SHB SHF SMURF1 SNX2 SNX4 SNX6 SRPK1 STAT1 STAT3 STAT5A STAT5B STK11 TERT TGFBR2 TP53 TTYH2 ULBP2
Entrez ID		3690	5156
HPRD ID		01428	01429
Ensembl ID		ENSG00000259207	ENSG00000134853
Uniprot IDs		P05106	P16234
PDB IDs		1JV2 1KUP 1KUZ 1L5G 1M1X 1M8O 1MIZ 1MK7 1MK9 1S4X 1TYE 1U8C 2K9J 2KNC 2KV9 2L1C 2L91 2LJD 2LJE 2LJF 2MTP 2N9Y 2Q6W 2RMZ 2RN0 2VC2 2VDK 2VDL 2VDM 2VDN 2VDO 2VDP 2VDQ 2VDR 3FCS 3FCU 3IJE 3NID 3NIF 3NIG 3T3M 3T3P 3ZDX 3ZDY 3ZDZ 3ZE0 3ZE1 3ZE2 4CAK 4G1E 4G1M 4MMX 4MMY 4MMZ 4O02 4Z7N 4Z7O 4Z7Q 5HDB 6AVQ 6AVR 6AVU 6BXB 6BXF 6BXJ 6CKB 6MK0 6MSL 6MSU 6NAJ 6V4P 7KN0 7L8P 7LA4 7TCT 7TD8 7THO 7TMZ 7TPD 7U60 7U9F 7U9V 7UBR 7UCY 7UDG 7UDH 7UE0 7UFH 7UH8 7UJE 7UJK 7UK9 7UKO 7UKP 7UKT 8GCD 8GCE 8IJ5 8T2U 8T2V 8XEI 8XEK 8XEL 8XEN 8XER 8XEZ 8XF6 8XFG 8XFO 9AXL 9DEQ 9DER	1GQ5 5GRN 5K5X 6A32 6JOI 6JOJ 6JOK 6JOL 7LBF 7RAM 8PQH 8PQI 8PQJ 8PQK 9GZH
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Regulation Of Cell-substrate Adhesion Focal Adhesion Regulation Of Cell Adhesion Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell-substrate Adhesion Regulation Of Cell Migration Regulation Of Cell Motility Regulation Of Locomotion Integrin-mediated Signaling Pathway Signal Transduction Positive Regulation Of Cell Adhesion Integrin Binding Cell Adhesion Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Cell-substrate Adhesion Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Signal Transduction Positive Regulation Of ERK1 And ERK2 Cascade Angiogenesis Cell-matrix Adhesion Cell Migration Regulation Of Signaling Regulation Of Cell Communication Positive Regulation Of MAPK Cascade Regulation Of MAPK Cascade Anchoring Junction Cell Motility Regulation Of Intracellular Signal Transduction Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction External Side Of Plasma Membrane Peptidyl-tyrosine Phosphorylation Regulation Of Multicellular Organismal Process Protein Autophosphorylation Plasma Membrane Positive Regulation Of Cell Population Proliferation Regulation Of Cell Population Proliferation Anatomical Structure Formation Involved In Morphogenesis Regulation Of Cellular Component Organization Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Developmental Process Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Transport	Regulation Of Cell Population Proliferation Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Response To Growth Factor Cellular Response To Growth Factor Stimulus Positive Regulation Of Signal Transduction Signal Transduction Positive Regulation Of Cell Population Proliferation Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Intracellular Signal Transduction Regulation Of Developmental Process Regulation Of Intracellular Signal Transduction Regulation Of Multicellular Organismal Process Regulation Of Signal Transduction Regulation Of Epithelial Cell Proliferation Developmental Process Cellular Developmental Process Regulation Of Mitotic Cell Cycle Regulation Of Signaling Regulation Of Cell Communication Regulation Of Cell Cycle Regulation Of Apoptotic Process Cell Population Proliferation Regulation Of Programmed Cell Death Regulation Of MAPK Cascade Regulation Of Cellular Component Organization Negative Regulation Of Apoptotic Process Regulation Of Cell Differentiation Negative Regulation Of Programmed Cell Death Regulation Of Cell Adhesion Cell Differentiation Animal Organ Development Negative Regulation Of Cell Differentiation Regulation Of Fibroblast Proliferation Positive Regulation Of Cell Migration Intracellular Signal Transduction Intracellular Signaling Cassette Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Regulation Of Growth Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Response To Epidermal Growth Factor Stimulus Positive Regulation Of Epithelial Cell Proliferation Regulation Of Cell Motility Regulation Of Cell Development Response To Epidermal Growth Factor Positive Regulation Of Multicellular Organismal Process Negative Regulation Of Developmental Process
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