LSM7 and PFKM

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		LSM7	PFKM
Description		LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated	phosphofructokinase, muscle
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex U6 SnRNP U12-type Spliceosomal Complex Cytosol U4/U6 X U5 Tri-snRNP Complex U2-type Prespliceosome U2-type Precatalytic Spliceosome Catalytic Step 2 Spliceosome Spliceosomal Tri-snRNP Complex Lsm2-8 Complex Lsm1-7-Pat1 Complex Ribonucleoprotein Complex	Nucleus Cytoplasm Cytosol 6-phosphofructokinase Complex Membrane Apical Plasma Membrane Sperm Principal Piece
	Molecular Function	RNA Binding Protein Binding U6 SnRNA Binding	Nucleotide Binding Catalytic Activity 6-phosphofructokinase Activity Protein Binding ATP Binding Phosphofructokinase Activity Kinase Activity Transferase Activity Kinase Binding Identical Protein Binding Metal Ion Binding Fructose Binding Fructose-6-phosphate Binding
	Biological Process	MRNA Splicing, Via Spliceosome Nuclear-transcribed MRNA Catabolic Process MRNA Processing RNA Splicing	Glycogen Catabolic Process Fructose 6-phosphate Metabolic Process Glycolytic Process Fructose 1,6-bisphosphate Metabolic Process Positive Regulation Of Insulin Secretion Glucose Homeostasis Positive Regulation Of Transcription By RNA Polymerase II Muscle Cell Cellular Homeostasis Carbohydrate Phosphorylation Glycolytic Process Through Fructose-6-phosphate Canonical Glycolysis Glycolysis From Storage Polysaccharide Through Glucose-1-phosphate
Pathways		mRNA decay by 5' to 3' exoribonuclease mRNA decay by 5' to 3' exoribonuclease mRNA Splicing - Major Pathway	Glycolysis
Drugs
Diseases			Glycogen storage diseases (GSD), including: von Gierke disease (GSD type Ia); Pompe disease (GSD type II); Cori disease, Forbe disease (GSD type III); Andersen disease (GSD type IV); McArdle disease (GSD type V); Hers disease (GSD type VI); Tarui disease (GSD type VII); Phosphorylase kinase deficiency (GSD type IX); Fanconi-Bickel syndrome (GSD type XI); Glycogen synthase deficiency (GSD type 0)
GWAS		Parkinson's disease ( 28892059)	Glycated hemoglobin levels ( 34059833) Hematocrit ( 27863252 32888494) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) High light scatter reticulocyte count ( 32888494) Immature fraction of reticulocytes ( 32888494) Longevity (90 years and older) ( 25199915) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Pulse pressure ( 30578418) Red blood cell count ( 32888494)
Interacting Genes		24 interacting genes: CEBPA DDIT4L EPHA2 EXOSC6 EXOSC8 LDB1 LSM1 LSM2 LSM3 LSM5 LSM6 LSM8 MYH13 NPY1R PFKM RAB29 RASSF5 SMN1 SNRPD3 SNRPF SYT17 TACC1 TCL1B ZSCAN26	20 interacting genes: ATP6V0A4 CAV3 CEBPA DLC1 DYNLL1 FHL2 HGS LSM7 MAPK3 NDUFB2 NOS1 PCNA PDGFRL PFKL SFRP2 SFRP4 SIAH1 SUMO2 TEAD4 UBTD1
Entrez ID		51690	5213
HPRD ID		06287	01988
Ensembl ID		ENSG00000130332	ENSG00000152556
Uniprot IDs		Q9UK45	A0A024R0Y5 A0A0S2Z4I1 A0A2R8Y891 F8VTQ3 P08237
PDB IDs		3JCR 5O9Z 6AH0 6AHD 6QW6 6QX9 7ABG 8H6E 8H6J 8H6K 8H6L 8QO9 8QXD 8QZS 8R08 8R09 8R0A 8R0B 8RM5	4OMT
Enriched GO Terms of Interacting Partners?		U4/U6 X U5 Tri-snRNP Complex Lsm2-8 Complex U2-type Precatalytic Spliceosome U6 SnRNP RNA Splicing, Via Transesterification Reactions Lsm1-7-Pat1 Complex MRNA Metabolic Process RNA Splicing MRNA Processing Spliceosomal Complex RNA Processing MRNA Splicing, Via Spliceosome RNA Metabolic Process Precatalytic Spliceosome MRNA Catabolic Process Ribonucleoprotein Complex Nucleobase-containing Compound Metabolic Process RNA Catabolic Process Spliceosomal SnRNP Assembly Nucleobase-containing Compound Catabolic Process Nucleic Acid Metabolic Process Small Nuclear Ribonucleoprotein Complex SMN-Sm Protein Complex RNA Binding Catalytic Step 2 Spliceosome P-body PICln-Sm Protein Complex Spliceosomal Complex Assembly U7 SnRNP 7-methylguanosine Cap Hypermethylation U4 SnRNA 3'-end Processing Nucleolar Exosome (RNase Complex) U4 SnRNP Nuclear MRNA Surveillance Methylosome U6 SnRNA Binding Protein-RNA Complex Assembly Cytoplasmic Exosome (RNase Complex) RNA Exonuclease Activity RRNA Catabolic Process Nuclear Exosome (RNase Complex) Exosome (RNase Complex) U1 SnRNP Nucleoplasm U5 SnRNP SnRNA 3'-end Processing Nuclear-transcribed MRNA Catabolic Process Macromolecule Catabolic Process U2-type Prespliceosome Assembly U12-type Spliceosomal Complex	Caveola Regulation Of Ubiquitin-dependent Protein Catabolic Process Anatomical Structure Formation Involved In Morphogenesis Heart Trabecula Formation Negative Regulation Of Signaling Negative Regulation Of Transport Negative Regulation Of Cell Communication Negative Regulation Of Potassium Ion Transport Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Z Disc Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Cell Development Myoblast Fusion Regulation Of Cell Communication Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Signaling Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Hematopoietic Stem Cell Proliferation Response To Hormone Positive Regulation Of Programmed Cell Death Positive Regulation Of Apoptotic Process Canonical Wnt Signaling Pathway Wnt-protein Binding Ubiquitin-like Protein Ligase Binding Protein-containing Complex Binding Cellular Developmental Process Sodium Channel Regulator Activity Positive Regulation Of Macromolecule Metabolic Process Regulation Of Membrane Repolarization T-tubule Cardiac Muscle Cell Development Regulation Of Sodium Ion Transmembrane Transport Regulation Of Nerve Growth Factor Receptor Activity Regulation Of Proteolysis Syncytium Formation By Plasma Membrane Fusion Negative Regulation Of Signal Transduction Negative Regulation Of Sarcomere Organization Cell-cell Fusion Regulation Of Signal Transduction By Receptor Internalization Cardiac Cell Development Syncytium Formation Negative Regulation Of Membrane Depolarization During Cardiac Muscle Cell Action Potential Negative Regulation Of Cell Population Proliferation Regulation Of Protein Catabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Regulation Of Transcription By RNA Polymerase II Response To Dexamethasone Positive Regulation Of Macromolecule Biosynthetic Process PCNA Complex
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