LSM7 and RAB29

Number of citations of the paper that reports this interaction (PubMedID 15231747)
47

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		LSM7	RAB29
Description		LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated	RAB29, member RAS oncogene family
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex U6 SnRNP U12-type Spliceosomal Complex Cytosol U4/U6 X U5 Tri-snRNP Complex U2-type Prespliceosome U2-type Precatalytic Spliceosome Catalytic Step 2 Spliceosome Spliceosomal Tri-snRNP Complex Lsm2-8 Complex Lsm1-7-Pat1 Complex Ribonucleoprotein Complex	Golgi Membrane Nucleoplasm Cytoplasm Mitochondrion Early Endosome Vacuole Golgi Apparatus Cis-Golgi Network Trans-Golgi Network Cytosol Cytoskeleton Plasma Membrane Endomembrane System Membrane Organelle Membrane Nuclear Membrane Vesicle Melanosome Perinuclear Region Of Cytoplasm Recycling Endosome Extracellular Exosome Intracellular Vesicle
	Molecular Function	RNA Binding Protein Binding U6 SnRNA Binding	Nucleotide Binding GTPase Activity Protein Binding GTP Binding GDP Binding Kinesin Binding Small GTPase Binding Dynein Complex Binding
	Biological Process	MRNA Splicing, Via Spliceosome Nuclear-transcribed MRNA Catabolic Process MRNA Processing RNA Splicing	Positive Regulation Of Receptor Recycling Intracellular Protein Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Mitochondrion Organization Golgi Organization Synapse Assembly Response To Bacterium Negative Regulation Of Neuron Projection Development Protein Transport Vesicle-mediated Transport Cell Differentiation Melanosome Organization T Cell Activation Retrograde Transport, Endosome To Golgi Host-mediated Perturbation Of Viral Process Positive Regulation Of T Cell Receptor Signaling Pathway Protein Localization To Membrane Positive Regulation Of Intracellular Protein Transport Protein Localization To Ciliary Membrane Regulation Of Retrograde Transport, Endosome To Golgi Cellular Detoxification
Pathways		mRNA decay by 5' to 3' exoribonuclease mRNA decay by 5' to 3' exoribonuclease mRNA Splicing - Major Pathway	RAB geranylgeranylation
Drugs
Diseases
GWAS		Parkinson's disease ( 28892059)	Liver enzyme levels (alkaline phosphatase) ( 33972514) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892)
Interacting Genes		24 interacting genes: CEBPA DDIT4L EPHA2 EXOSC6 EXOSC8 LDB1 LSM1 LSM2 LSM3 LSM5 LSM6 LSM8 MYH13 NPY1R PFKM RAB29 RASSF5 SMN1 SNRPD3 SNRPF SYT17 TACC1 TCL1B ZSCAN26	9 interacting genes: BEND7 CRYAA CSTPP1 LDOC1 LRRK1 LSM7 REL TRIM27 TRIM32
Entrez ID		51690	8934
HPRD ID		06287	11962
Ensembl ID		ENSG00000130332	ENSG00000117280
Uniprot IDs		Q9UK45	B2R7I9 O14966 Q6FGU7
PDB IDs		3JCR 5O9Z 6AH0 6AHD 6QW6 6QX9 7ABG 8H6E 8H6J 8H6K 8H6L 8QO9 8QXD 8QZS 8R08 8R09 8R0A 8R0B 8RM5	6HH2 8FO2 8FO8 8FO9
Enriched GO Terms of Interacting Partners?		U4/U6 X U5 Tri-snRNP Complex Lsm2-8 Complex U2-type Precatalytic Spliceosome U6 SnRNP RNA Splicing, Via Transesterification Reactions Lsm1-7-Pat1 Complex MRNA Metabolic Process RNA Splicing MRNA Processing Spliceosomal Complex RNA Processing MRNA Splicing, Via Spliceosome RNA Metabolic Process Precatalytic Spliceosome MRNA Catabolic Process Ribonucleoprotein Complex Nucleobase-containing Compound Metabolic Process RNA Catabolic Process Spliceosomal SnRNP Assembly Nucleobase-containing Compound Catabolic Process Nucleic Acid Metabolic Process Small Nuclear Ribonucleoprotein Complex SMN-Sm Protein Complex RNA Binding Catalytic Step 2 Spliceosome P-body PICln-Sm Protein Complex Spliceosomal Complex Assembly U7 SnRNP 7-methylguanosine Cap Hypermethylation U4 SnRNA 3'-end Processing Nucleolar Exosome (RNase Complex) U4 SnRNP Nuclear MRNA Surveillance Methylosome U6 SnRNA Binding Protein-RNA Complex Assembly Cytoplasmic Exosome (RNase Complex) RNA Exonuclease Activity RRNA Catabolic Process Nuclear Exosome (RNase Complex) Exosome (RNase Complex) U1 SnRNP Nucleoplasm U5 SnRNP SnRNA 3'-end Processing Nuclear-transcribed MRNA Catabolic Process Macromolecule Catabolic Process U2-type Prespliceosome Assembly U12-type Spliceosomal Complex	Suppression Of Viral Release By Host Regulation Of Viral Transcription Negative Regulation Of Viral Transcription Negative Regulation Of Type I Interferon Production Negative Regulation Of Viral Process Protein K63-linked Ubiquitination Positive Regulation Of Interleukin-17-mediated Signaling Pathway Actin Ubiquitination Protein Polymerization Positive Regulation Of Chemokine (C-C Motif) Ligand 20 Production Protein Localization To Phagocytic Vesicle
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