ENPP3 and CNKSR1

Number of citations of the paper that reports this interaction (PubMedID 34187934)
69

Data Source:
BioGRID (pull down)

		ENPP3	CNKSR1
Description		ectonucleotide pyrophosphatase/phosphodiesterase 3	connector enhancer of kinase suppressor of Ras 1
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GO Annotations	Cellular Component	Extracellular Region Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Apical Plasma Membrane Perinuclear Region Of Cytoplasm Extracellular Exosome	Cytoplasm Plasma Membrane Cell-cell Junction Cell Cortex Membrane
	Molecular Function	Nucleic Acid Binding Bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) Activity Phosphodiesterase I Activity Calcium Ion Binding Zinc Ion Binding Pyrophosphatase Activity Hydrolase Activity Bis(5'-adenosyl)-pentaphosphatase Activity GTP Diphosphatase Activity UTP Diphosphatase Activity Metal Ion Binding Nucleoside Triphosphate Diphosphatase Activity ATP Diphosphatase Activity Bis(5'-adenosyl)-triphosphatase Activity	Protein Binding Protein-macromolecule Adaptor Activity
	Biological Process	Basophil Activation Involved In Immune Response Pyrimidine Nucleotide Metabolic Process Phosphate-containing Compound Metabolic Process Nucleoside Triphosphate Catabolic Process Inorganic Diphosphate Transport Negative Regulation Of Mast Cell Activation Involved In Immune Response ATP Metabolic Process Negative Regulation Of Inflammatory Response Phosphate Ion Homeostasis Negative Regulation Of Mast Cell Proliferation	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Pathways		Vitamin B5 (pantothenate) metabolism	MAP2K and MAPK activation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants Signaling by RAF1 mutants
Drugs
Diseases
GWAS		Body mass index (change over time) in lung cancer ( 28044437) L-arginine levels ( 25245031) Osteoarthritis of the hand ( 28855172) Phosphorus levels ( 29403010) Resistant hypertension ( 31545351) Response to fenofibrate (adiponectin levels) ( 23149075) Serum alkaline phosphatase levels ( 33547301) Type 2 diabetes ( 32499647)	Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189)
Interacting Genes		1 interacting genes: CNKSR1	37 interacting genes: ARHGEF1 BRAP CADM4 CYTH3 CYTH4 DSCR9 DUSP10 DUSP7 ENPP3 G6PC3 ILKAP MAP2K2 MAP2K7 MAP3K10 PIN1 PPFIA1 PPFIA3 PPP1R14C PPP1R8 PTPN18 PTPN6 PTPRH PTPRJ PTPRM PTPRR RAF1 RALGDS RASSF1 RHOA RHPN1 SASH1 SMAD4 STK3 STK4 TCAF1 ZDHHC17 ZGPAT
Entrez ID		5169	10256
HPRD ID		03715	11937
Ensembl ID		ENSG00000154269	ENSG00000142675
Uniprot IDs		F8W6H5 O14638	B4DL25 G3V160 Q53GM7 Q969H4
PDB IDs		6C01 6C02	1WWV
Enriched GO Terms of Interacting Partners?			Regulation Of MAPK Cascade Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity MAPK Cascade Intracellular Signaling Cassette Regulation Of Protein Phosphorylation Regulation Of Intracellular Signal Transduction Regulation Of Phosphorylation Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Regulation Of Protein Modification Process Dephosphorylation Regulation Of Phosphorus Metabolic Process Protein Dephosphorylation Transmembrane Receptor Protein Tyrosine Phosphatase Activity Negative Regulation Of MAPK Cascade Negative Regulation Of Signal Transduction Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Protein Serine/threonine Kinase Activity Intracellular Signal Transduction Phosphate-containing Compound Metabolic Process Protein Modification Process Positive Regulation Of Protein Phosphorylation Negative Regulation Of ERK1 And ERK2 Cascade Regulation Of Protein Kinase Activity Positive Regulation Of Phosphorylation Regulation Of Kinase Activity Positive Regulation Of Protein Modification Process Signal Transduction Positive Regulation Of Phosphate Metabolic Process Regulation Of Cell Motility Positive Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of Cell Motility Regulation Of Protein Metabolic Process Negative Regulation Of Locomotion Regulation Of Locomotion Regulation Of MAP Kinase Activity Peptidyl-tyrosine Dephosphorylation ERBB2 Signaling Pathway Hydrolase Activity Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Cell Population Proliferation Small GTPase-mediated Signal Transduction Negative Regulation Of Mast Cell Activation Involved In Immune Response Primitive Hemopoiesis Anatomical Structure Formation Involved In Morphogenesis Negative Regulation Of ERBB Signaling Pathway
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