OAZ3 and POMC

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		OAZ3	POMC
Description		ornithine decarboxylase antizyme 3	proopiomelanocortin
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Sperm Flagellum Blood Microparticle	Extracellular Region Extracellular Space Cytoplasm Peroxisome Peroxisomal Matrix Secretory Granule Secretory Granule Lumen
	Molecular Function	Protein Binding Ornithine Decarboxylase Inhibitor Activity Ankyrin Repeat Binding	G Protein-coupled Receptor Binding Signaling Receptor Binding Hormone Activity Protein Binding Type 3 Melanocortin Receptor Binding Type 4 Melanocortin Receptor Binding Type 1 Melanocortin Receptor Binding
	Biological Process	Polyamine Biosynthetic Process Spermatogenesis Positive Regulation Of Protein Catabolic Process Negative Regulation Of Stress Fiber Assembly Viral Translational Frameshifting Positive Regulation Of Intracellular Protein Transport Negative Regulation Of Polyamine Transmembrane Transport	Generation Of Precursor Metabolites And Energy Signal Transduction Neuropeptide Signaling Pathway Cell-cell Signaling Regulation Of Blood Pressure Calcium-mediated Signaling Killing Of Cells Of Another Organism Regulation Of Appetite Negative Regulation Of Tumor Necrosis Factor Production Cellular Pigmentation Modulation Of Process Of Another Organism Glucose Homeostasis Positive Regulation Of Transcription By RNA Polymerase II Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Regulation Of Glycogen Metabolic Process Positive Regulation Of Neutrophil Mediated Killing Of Fungus Positive Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Oxytocin Production Response To Melanocyte-stimulating Hormone Regulation Of Corticosterone Secretion
Pathways		Regulation of ornithine decarboxylase (ODC) Metabolism of polyamines	Opioid Signalling Androgen biosynthesis Glucocorticoid biosynthesis G-protein activation Peptide hormone biosynthesis Endogenous sterols Peptide ligand-binding receptors G alpha (s) signalling events G alpha (i) signalling events Defective ACTH causes obesity and POMCD Interleukin-4 and Interleukin-13 signaling FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes Transcriptional and post-translational regulation of MITF-M expression and activity
Drugs			Loperamide Etorphine Dihydromorphine
Diseases
GWAS		Asthma ( 31619474) Carotid plaque burden ( 28282560) Insomnia symptoms (never/rarely vs. sometimes/usually) ( 30804566) Insomnia symptoms (never/rarely vs. usually) ( 30804566)	Body mass index ( 20935630 23669352 26426971) Body mass index (age <50) ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Crohn's disease ( 28067908) Height ( 18391951 23563607 28552196) Hip circumference adjusted for BMI ( 34021172) Inflammatory bowel disease ( 28067908) Obesity ( 23563607) Pubertal anthropometrics ( 23449627) Red vs. brown/black hair color ( 30531825) Type 1 diabetes ( 21980299)
Interacting Genes		14 interacting genes: AZIN2 BLZF1 C1orf94 GGN IKZF3 L3MBTL3 OAZ1 POMC POU6F2 REL SMAD1 TEPSIN ZBTB42 ZNF620	28 interacting genes: ABI2 AIRIM APP ATP6V0D2 BHLHA9 CCDC102B ESRRG FGF10 GLYCTK HDDC2 HLA-DRB3 HSF2BP KLHL42 MC1R MC2R MC3R MC4R MC5R MEP1A MKRN3 NFKBID NRDC NTAQ1 OAZ3 PAM SUOX TXN2 VTN
Entrez ID		51686	5443
HPRD ID		18670	01462
Ensembl ID		ENSG00000143450	ENSG00000115138
Uniprot IDs		A0A0G2JH29 H0Y7Y4 Q9UMX2	P01189
PDB IDs			4XNH 4XPD 4Y49 6TUB 7F53 7F54 7PIV 8F7Q 8INR 8IOC
Enriched GO Terms of Interacting Partners?		Polyamine Biosynthetic Process Polyamine Metabolic Process Regulation Of DNA-templated Transcription Mesodermal Cell Fate Commitment Regulation Of Primary Metabolic Process Homomeric SMAD Protein Complex Osteoblast Fate Commitment Regulation Of RNA Biosynthetic Process Ubiquitin Protein Ligase Binding DNA-binding Transcription Factor Activity DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Amine Biosynthetic Process Ornithine Decarboxylase Inhibitor Activity Biogenic Amine Biosynthetic Process Amine Metabolic Process Negative Regulation Of Polyamine Transmembrane Transport Biogenic Amine Metabolic Process Positive Regulation Of Neutrophil Mediated Killing Of Fungus Positive Regulation Of Oxytocin Production Response To Melanocyte-stimulating Hormone Cis-Golgi Network Negative Regulation Of Transcription Initiation-coupled Chromatin Remodeling Methylation-dependent Protein Binding Ornithine Decarboxylase Activator Activity Arginine Decarboxylase Activity Granular Vesicle Agmatine Biosynthetic Process Ornithine Decarboxylase Activity Positive Regulation Of Polyamine Transmembrane Transport Putrescine Biosynthetic Process From Arginine, Via Ornithine Trans-Golgi Network Membrane Organization Coated Vesicle Membrane Regulation Of Transcription By RNA Polymerase II Cellular Pigmentation Type 1 Melanocortin Receptor Binding Type 4 Melanocortin Receptor Binding Positive Regulation Of Killing Of Cells Of Another Organism Type 3 Melanocortin Receptor Binding NF-kappaB Complex Ornithine Metabolic Process Anti-Mullerian Hormone Receptor Signaling Pathway Regulation Of RNA Metabolic Process Putrescine Biosynthetic Process Regulation Of Corticosterone Secretion Positive Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Neutrophil Mediated Cytotoxicity	Melanocortin Receptor Activity Melanocyte-stimulating Hormone Receptor Activity Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Regulation Of Feeding Behavior Positive Regulation Of Membrane Protein Ectodomain Proteolysis Positive Regulation Of CAMP/PKA Signal Transduction Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Hormone Binding G Protein-coupled Receptor Activity Regulation Of Behavior Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Chemoattractant Activity Amylin Binding Positive Regulation Of Toll Signaling Pathway G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Multicellular Organismal Process Protein Binding Protein Serine/threonine Kinase Binding Regulation Of Membrane Protein Ectodomain Proteolysis Positive Regulation Of Hair Follicle Cell Proliferation Positive Regulation Of Urothelial Cell Proliferation Lung Proximal/distal Axis Specification Bronchiole Morphogenesis Urothelial Cell Proliferation Embryonic Genitalia Morphogenesis Semicircular Canal Fusion Mesenchymal-epithelial Cell Signaling Involved In Lung Development Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Submandibular Salivary Gland Formation Corticotropin Receptor Activity Neuropeptide Binding Peptidylamidoglycolate Lyase Activity Peptidylglycine Monooxygenase Activity Fatty Acid Primary Amide Biosynthetic Process Sulfite Oxidase Activity Symbiont-containing Vacuole Protein-N-terminal Glutamine Amidohydrolase Activity Glycerate Kinase Activity
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