PDHB and RBM11

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		PDHB	RBM11
Description		pyruvate dehydrogenase E1 subunit beta	RNA binding motif protein 11
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Mitochondrion Mitochondrial Matrix Pyruvate Dehydrogenase Complex	Nucleus Nucleoplasm Nuclear Speck
	Molecular Function	Pyruvate Dehydrogenase (acetyl-transferring) Activity Protein Binding Oxidoreductase Activity Metal Ion Binding	Nucleic Acid Binding RNA Binding Single-stranded RNA Binding Protein Binding Poly(U) RNA Binding Protein Homodimerization Activity
	Biological Process	Glucose Metabolic Process Pyruvate Decarboxylation To Acetyl-CoA Tricarboxylic Acid Cycle Purine-containing Compound Biosynthetic Process	Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing Cell Differentiation Cellular Response To Oxidative Stress
Pathways		Regulation of pyruvate dehydrogenase (PDH) complex Signaling by Retinoic Acid Mitochondrial protein degradation PDH complex synthesizes acetyl-CoA from PYR
Drugs		Pyruvic acid NADH
Diseases		Pyruvate dehydrogenase complex deficiency; X-linked Leigh syndrome
GWAS		Apolipoprotein B levels ( 32203549) Composite immunoglobulin trait (IgA x IgG/IgM) ( 28628107) IgG levels ( 28628107) LDL cholesterol levels ( 32203549) Refractive error ( 32231278) Systemic lupus erythematosus ( 26502338 28714469) Type 1 diabetes autoantibodies in high risk HLA genotype individuals (time to event) ( 29310926) vWF levels ( 30586737)
Interacting Genes		18 interacting genes: ADORA2A AKT1 ANXA7 CDKN1A FCER1A GNB2 GRB7 HSD17B10 ITGB1 PDHA1 PDHA2 PDHX PFDN1 RAP1B RBM11 RCC1 TRIM63 TSC22D1	78 interacting genes: ACOT1 APP ATIC ATOSB ATRX BHLHE40 CEP85 CERCAM CHCHD3 CHD6 CNTNAP1 COPA CRYAB DALRD3 DAZAP2 DCAF8 DDX27 DDX6 DST DTX2 EDIL3 ENKD1 FN3K GABPB1 GADD45GIP1 GLIS2 GPATCH2L HERPUD2 HMG20A LRP1 MADD MAN1A2 MECOM MED13L METAP1 MYO15B NEFL NMT2 PCBP1 PCM1 PCYT1A PDHB PIBF1 PLCG1 PLEKHB1 POLG PRRC2A PSMD4 QKI RBFOX3 RHOXF2 RNF38 SAXO4 SCNM1 SCYL2 SF3B2 SNRNP70 SNRPA SNRPC SPRED1 STAMBP TUBB4A U2AF2 VIM ZCCHC8 ZFHX3 ZKSCAN5 ZMYND10 ZNF189 ZNF214 ZNF251 ZNF302 ZNF329 ZNF414 ZNF606 ZNF7 ZNF774 ZNF83
Entrez ID		5162	54033
HPRD ID		01530	10185
Ensembl ID		ENSG00000168291	ENSG00000185272
Uniprot IDs		A0A384MDR8 P11177	P57052
PDB IDs		1NI4 2OZL 3EXE 3EXF 3EXG 3EXH 3EXI 6CER 6CFO	2YWK
Enriched GO Terms of Interacting Partners?		Pyruvate Decarboxylation To Acetyl-CoA Pyruvate Dehydrogenase Complex Acetyl-CoA Biosynthetic Process Pyruvate Dehydrogenase (acetyl-transferring) Activity Acetyl-CoA Metabolic Process Oxidoreductase Activity, Acting On The Aldehyde Or Oxo Group Of Donors, Disulfide As Acceptor Protein-containing Complex Binding Pyruvate Metabolic Process Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Fibroblast Migration Acyl-CoA Metabolic Process Sulfur Compound Biosynthetic Process Positive Regulation Of Amino Acid Transport Cell Migration Involved In Sprouting Angiogenesis Glucose Metabolic Process Cellular Response To Low-density Lipoprotein Particle Stimulus Tricarboxylic Acid Cycle Amide Biosynthetic Process Cellular Response To Lipoprotein Particle Stimulus Regulation Of Fibroblast Migration Carboxylic Acid Metabolic Process TRNA Methylation Organic Acid Metabolic Process Monosaccharide Metabolic Process Hexose Metabolic Process Blood Vessel Endothelial Cell Migration Regulation Of TRNA Methylation Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition High-affinity IgE Receptor Activity Isoursodeoxycholate 7-beta-dehydrogenase (NAD+) Activity Chenodeoxycholate 7-alpha-dehydrogenase (NAD+) Activity 3-hydroxy-2-methylbutyryl-CoA Dehydrogenase Activity Cholate 7-alpha-dehydrogenase (NAD+) Activity Ursodeoxycholate 7-beta-dehydrogenase (NAD+) Activity Mitochondrial Matrix Myoblast Fate Specification Integrin Alpha7-beta1 Complex Cellular Defense Response Protein Kinase Binding Monocarboxylic Acid Metabolic Process Excitatory Postsynaptic Potential Cellular Response To Amino Acid Starvation Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Protein Localization To Lysosome PCNA-p21 Complex Negative Regulation Of Cardiac Muscle Tissue Regeneration Type I Hypersensitivity 17-beta-hydroxysteroid Dehydrogenase (NAD+) Activity	Nucleus RNA Splicing, Via Transesterification Reactions U1 SnRNA Binding MRNA Splicing, Via Spliceosome DNA Binding Spliceosomal Complex Zinc Ion Binding RNA Splicing Metal Ion Binding Nucleic Acid Binding U2-type Prespliceosome U1 SnRNP Regulation Of RNA Metabolic Process Astrocyte Activation Involved In Immune Response MRNA Binding MRNA Processing Commitment Complex Microtubule-based Process Stress Granule Assembly U1 SnRNP Binding
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