PDHB and PDHA1

Number of citations of the paper that reports this interaction (PMID 22939629)
44

Data Source:
BioGRID (biochemical, biochemical)
HPRD (in vivo)

		PDHB	PDHA1
Gene Name		pyruvate dehydrogenase (lipoamide) beta	pyruvate dehydrogenase (lipoamide) alpha 1
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Mitochondrion Mitochondrial Matrix Pyruvate Dehydrogenase Complex Extracellular Vesicular Exosome	Nucleus Mitochondrion Mitochondrial Matrix Pyruvate Dehydrogenase Complex
	Molecular Function	Pyruvate Dehydrogenase Activity Pyruvate Dehydrogenase (acetyl-transferring) Activity Protein Binding	Pyruvate Dehydrogenase Activity Pyruvate Dehydrogenase (acetyl-transferring) Activity
	Biological Process	Glucose Metabolic Process Acetyl-CoA Biosynthetic Process From Pyruvate Pyruvate Metabolic Process Tricarboxylic Acid Cycle Regulation Of Acetyl-CoA Biosynthetic Process From Pyruvate Cellular Metabolic Process Small Molecule Metabolic Process	Glucose Metabolic Process Acetyl-CoA Biosynthetic Process From Pyruvate Pyruvate Metabolic Process Glycolytic Process Tricarboxylic Acid Cycle Regulation Of Acetyl-CoA Biosynthetic Process From Pyruvate Cellular Metabolic Process Small Molecule Metabolic Process
Pathways		Regulation of pyruvate dehydrogenase (PDH) complex Pyruvate metabolism Signaling by Retinoic Acid Pyruvate metabolism and Citric Acid (TCA) cycle The citric acid (TCA) cycle and respiratory electron transport	Regulation of pyruvate dehydrogenase (PDH) complex Pyruvate metabolism Signaling by Retinoic Acid Pyruvate metabolism and Citric Acid (TCA) cycle The citric acid (TCA) cycle and respiratory electron transport
Drugs		Pyruvic acid NADH	NADH
Diseases
GWAS
Protein-Protein Interactions		15 interactors: ANXA7 CDKN1A DLAT FCER1A GNB2 GRB7 ITGB1 PDHA1 PDHA2 PDHX PFDN1 RAP1B RCC1 TRIM63 TSC22D1	8 interactors: DLAT EIF6 PDHB PDK1 PDK2 PDK3 PDK4 PDP1
Entrez ID		5162	5160
HPRD ID		01530	02420
Ensembl ID		ENSG00000168291	ENSG00000131828
Uniprot IDs		P11177	P08559
PDB IDs		1NI4 2OZL 3EXE 3EXF 3EXG 3EXH 3EXI	1NI4 2OZL 3EXE 3EXF 3EXG 3EXH 3EXI
Enriched GO Terms of Interacting Partners?		Regulation Of Acetyl-CoA Biosynthetic Process From Pyruvate Regulation Of Acyl-CoA Biosynthetic Process Pyruvate Metabolic Process Tricarboxylic Acid Cycle Citrate Metabolic Process Tricarboxylic Acid Metabolic Process Aerobic Respiration Regulation Of Cellular Ketone Metabolic Process Regulation Of Phosphorus Metabolic Process Regulation Of Metabolic Process Monocarboxylic Acid Metabolic Process Regulation Of Fatty Acid Metabolic Process Energy Derivation By Oxidation Of Organic Compounds Glucose Metabolic Process Generation Of Precursor Metabolites And Energy G1/S Transition Of Mitotic Cell Cycle Hemostasis Response To Organic Cyclic Compound Cellular Respiration Hexose Metabolic Process Carboxylic Acid Metabolic Process Regulation Of Body Fluid Levels Monosaccharide Metabolic Process Mitotic Cell Cycle Phase Transition Cellular Response To Ionizing Radiation Organic Acid Metabolic Process Regulation Of Cellular Process Cell Cycle Phase Transition Regulation Of Lipid Metabolic Process Positive Regulation Of Protein Phosphorylation Positive Regulation Of Interleukin-3 Biosynthetic Process Positive Regulation Of Type I Hypersensitivity Regulation Of Vesicle-mediated Transport Positive Regulation Of Phosphorylation Glycolytic Process Cellular Response To Organic Cyclic Compound Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Biosynthetic Process Regulation Of Collagen Catabolic Process Positive Regulation Of Protein Modification Process Small Molecule Metabolic Process Blood Coagulation Positive Regulation Of MAPK Cascade Response To Hormone Negative Regulation Of Synaptic Vesicle Exocytosis Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Calcium-independent Cell-matrix Adhesion Regulation Of Granulocyte Macrophage Colony-stimulating Factor Biosynthetic Process Acetyl-CoA Biosynthetic Process From Pyruvate Positive Regulation Of Protein Kinase Activity Response To Organic Substance	Regulation Of Acetyl-CoA Biosynthetic Process From Pyruvate Regulation Of Acyl-CoA Biosynthetic Process Regulation Of Fatty Acid Metabolic Process Pyruvate Metabolic Process Regulation Of Lipid Metabolic Process Glucose Metabolic Process Hexose Metabolic Process Regulation Of Cellular Ketone Metabolic Process Monosaccharide Metabolic Process Monocarboxylic Acid Metabolic Process Carboxylic Acid Metabolic Process Organic Acid Metabolic Process Regulation Of Glucose Metabolic Process Regulation Of Phosphorus Metabolic Process Hypoxia-inducible Factor-1alpha Signaling Pathway Regulation Of Carbohydrate Metabolic Process Carbohydrate Metabolic Process Small Molecule Metabolic Process Insulin Receptor Signaling Pathway Glucose Homeostasis Cellular Response To Insulin Stimulus Tricarboxylic Acid Cycle Response To Insulin Cellular Response To Fatty Acid Citrate Metabolic Process Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Tricarboxylic Acid Metabolic Process Aerobic Respiration Regulation Of PH Response To Fatty Acid Response To Peptide Hormone Cellular Response To Organonitrogen Compound Response To Peptide Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Protein Phosphorylation Cellular Response To Oxygen Levels Acetyl-CoA Biosynthetic Process From Pyruvate Cellular Response To Hormone Stimulus Cellular Protein Metabolic Process Cellular Response To Stress Phosphate-containing Compound Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Metabolic Process Cellular Respiration Cellular Response To Acid Chemical Cellular Response To Nutrient Levels Intrinsic Apoptotic Signaling Pathway Cellular Protein Modification Process
Tagcloud ?		actg1 alteration birc7 chrcc chromophobe cpq distinctions ectopic enabled exome faah2 fusions met mitf mutated nccrccs nf2 oncocytoma oncocytomas papillary pdxdc1 pnkd prcc rcc slc5a3 transcriptome trcc unreported znf765	coffin decalvans dxs1052 dxs1053 dxs1195 dxs1229 dxs197 dxs207 dxs274 dxs365 dxs414 dxs418 dxs443 dxs451 dxs7101 dxs7161 dxs7592 dxs7593 dxs987 dxs989 dxs999 follicularis kfsd kqst80h1 lowry retinoschisis rp15 spinulosa xlh
Tagcloud (Difference) ?		actg1 alteration birc7 chrcc chromophobe cpq distinctions ectopic enabled exome faah2 fusions met mitf mutated nccrccs nf2 oncocytoma oncocytomas papillary pdxdc1 pnkd prcc rcc slc5a3 transcriptome trcc unreported znf765	coffin decalvans dxs1052 dxs1053 dxs1195 dxs1229 dxs197 dxs207 dxs274 dxs365 dxs414 dxs418 dxs443 dxs451 dxs7101 dxs7161 dxs7592 dxs7593 dxs987 dxs989 dxs999 follicularis kfsd kqst80h1 lowry retinoschisis rp15 spinulosa xlh
Tagcloud (Intersection) ?