PDHB and GRB7

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		PDHB	GRB7
Gene Name		pyruvate dehydrogenase (lipoamide) beta	growth factor receptor-bound protein 7
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Mitochondrion Mitochondrial Matrix Pyruvate Dehydrogenase Complex Extracellular Vesicular Exosome	Cytosol Plasma Membrane Focal Adhesion Cytoplasmic Stress Granule Cell Projection
	Molecular Function	Pyruvate Dehydrogenase Activity Pyruvate Dehydrogenase (acetyl-transferring) Activity Protein Binding	RNA Binding SH3/SH2 Adaptor Activity Protein Binding Protein Kinase Binding Phosphatidylinositol Binding Identical Protein Binding
	Biological Process	Glucose Metabolic Process Acetyl-CoA Biosynthetic Process From Pyruvate Pyruvate Metabolic Process Tricarboxylic Acid Cycle Regulation Of Acetyl-CoA Biosynthetic Process From Pyruvate Cellular Metabolic Process Small Molecule Metabolic Process	Epidermal Growth Factor Receptor Signaling Pathway Blood Coagulation Positive Regulation Of Signal Transduction Negative Regulation Of Translation Positive Regulation Of Cell Migration Stress Granule Assembly Leukocyte Migration
Pathways		Regulation of pyruvate dehydrogenase (PDH) complex Pyruvate metabolism Signaling by Retinoic Acid Pyruvate metabolism and Citric Acid (TCA) cycle The citric acid (TCA) cycle and respiratory electron transport	Signaling by PDGF Signaling by SCF-KIT Signaling by ERBB2 Downstream signal transduction GRB7 events in ERBB2 signaling Tie2 Signaling Cell surface interactions at the vascular wall
Drugs		Pyruvic acid NADH
Diseases
GWAS
Protein-Protein Interactions		15 interactors: ANXA7 CDKN1A DLAT FCER1A GNB2 GRB7 ITGB1 PDHA1 PDHA2 PDHX PFDN1 RAP1B RCC1 TRIM63 TSC22D1	39 interactors: A1BG AGAP1 ATP5B CALM1 CAV1 CPNE6 DOCK7 DYNC1I1 EGFR ERBB2 ERBB3 FGB FLAD1 GNB2 GRB2 HADHB INSR KCTD6 KIT KMT2B LAX1 LY6G6F MAP3K14 MSH2 PDGFRB PDHB PHAX PKM PTK2 RET RND1 RPS2 SETDB1 SHC1 TEK TLE1 TMSB4X TRIM36 ZBTB16
Entrez ID		5162	2886
HPRD ID		01530	03311
Ensembl ID		ENSG00000168291	ENSG00000141738
Uniprot IDs		P11177	Q14451
PDB IDs		1NI4 2OZL 3EXE 3EXF 3EXG 3EXH 3EXI	1MW4 1WGR 2L4K 2QMS 3PQZ
Enriched GO Terms of Interacting Partners?		Regulation Of Acetyl-CoA Biosynthetic Process From Pyruvate Regulation Of Acyl-CoA Biosynthetic Process Pyruvate Metabolic Process Tricarboxylic Acid Cycle Citrate Metabolic Process Tricarboxylic Acid Metabolic Process Aerobic Respiration Regulation Of Cellular Ketone Metabolic Process Regulation Of Phosphorus Metabolic Process Regulation Of Metabolic Process Monocarboxylic Acid Metabolic Process Regulation Of Fatty Acid Metabolic Process Energy Derivation By Oxidation Of Organic Compounds Glucose Metabolic Process Generation Of Precursor Metabolites And Energy G1/S Transition Of Mitotic Cell Cycle Hemostasis Response To Organic Cyclic Compound Cellular Respiration Hexose Metabolic Process Carboxylic Acid Metabolic Process Regulation Of Body Fluid Levels Monosaccharide Metabolic Process Mitotic Cell Cycle Phase Transition Cellular Response To Ionizing Radiation Organic Acid Metabolic Process Regulation Of Cellular Process Cell Cycle Phase Transition Regulation Of Lipid Metabolic Process Positive Regulation Of Protein Phosphorylation Positive Regulation Of Interleukin-3 Biosynthetic Process Positive Regulation Of Type I Hypersensitivity Regulation Of Vesicle-mediated Transport Positive Regulation Of Phosphorylation Glycolytic Process Cellular Response To Organic Cyclic Compound Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Biosynthetic Process Regulation Of Collagen Catabolic Process Positive Regulation Of Protein Modification Process Small Molecule Metabolic Process Blood Coagulation Positive Regulation Of MAPK Cascade Response To Hormone Negative Regulation Of Synaptic Vesicle Exocytosis Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Calcium-independent Cell-matrix Adhesion Regulation Of Granulocyte Macrophage Colony-stimulating Factor Biosynthetic Process Acetyl-CoA Biosynthetic Process From Pyruvate Positive Regulation Of Protein Kinase Activity Response To Organic Substance	Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Cell Adhesion Peptidyl-tyrosine Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Phosphorus Metabolic Process Positive Regulation Of Phosphorylation Positive Regulation Of Catalytic Activity Positive Regulation Of Transferase Activity Regulation Of Phosphorylation Positive Regulation Of Protein Phosphorylation Intracellular Signal Transduction Immune System Process Regulation Of MAPK Cascade Regulation Of Kinase Activity Positive Regulation Of Kinase Activity Fibroblast Growth Factor Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Fc Receptor Signaling Pathway Regulation Of Protein Phosphorylation Positive Regulation Of Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Positive Regulation Of Protein Modification Process Regulation Of MAP Kinase Activity Positive Regulation Of Cellular Protein Metabolic Process Response To Fibroblast Growth Factor Regulation Of Protein Kinase Activity Neurotrophin TRK Receptor Signaling Pathway Wound Healing Immune Response-regulating Signaling Pathway Neurotrophin Signaling Pathway Positive Regulation Of Protein Kinase Activity Positive Regulation Of Protein Metabolic Process Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Cellular Ketone Metabolic Process Regulation Of Catalytic Activity Regulation Of Immune System Process Regulation Of Signal Transduction Response To Wounding Regulation Of Cellular Amino Acid Metabolic Process Positive Regulation Of Protein Serine/threonine Kinase Activity Peptidyl-amino Acid Modification Signal Transduction By Phosphorylation Positive Regulation Of Cellular Metabolic Process Response To Hormone Regulation Of Cellular Protein Metabolic Process
Tagcloud ?		actg1 alteration birc7 chrcc chromophobe cpq distinctions ectopic enabled exome faah2 fusions met mitf mutated nccrccs nf2 oncocytoma oncocytomas papillary pdxdc1 pnkd prcc rcc slc5a3 transcriptome trcc unreported znf765	adapter appears avidly bear bps conversely denote domain domains dramatically existence grb10 grb14 homology interact interaction interacts ir location loop obvious paired pleckstrin resemblance sh2 summary unidentified y1150f y1151f
Tagcloud (Difference) ?		actg1 alteration birc7 chrcc chromophobe cpq distinctions ectopic enabled exome faah2 fusions met mitf mutated nccrccs nf2 oncocytoma oncocytomas papillary pdxdc1 pnkd prcc rcc slc5a3 transcriptome trcc unreported znf765	adapter appears avidly bear bps conversely denote domain domains dramatically existence grb10 grb14 homology interact interaction interacts ir location loop obvious paired pleckstrin resemblance sh2 summary unidentified y1150f y1151f
Tagcloud (Intersection) ?