GET4 and SEC61B

Number of citations of the paper that reports this interaction (PubMedID 20676083)
30

Data Source:
BioGRID (pull down)

		GET4	SEC61B
Description		guided entry of tail-anchored proteins factor 4	SEC61 translocon subunit beta
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GO Annotations	Cellular Component	Nucleoplasm Chromosome Nucleolus Cytoplasm Cytosol BAT3 Complex	Endoplasmic Reticulum Sec61 Translocon Complex Endoplasmic Reticulum Membrane Cytosol Membrane Endoplasmic Reticulum Sec Complex Endoplasmic Reticulum Quality Control Compartment
	Molecular Function	Protein Binding Protein-folding Chaperone Binding Protein Carrier Chaperone	RNA Binding Guanyl-nucleotide Exchange Factor Activity Protein Binding Ribosome Binding Epidermal Growth Factor Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Regulation Of Protein Stability ERAD Pathway Maintenance Of Unfolded Protein Protein Insertion Into ER Membrane Tail-anchored Membrane Protein Insertion Into ER Membrane	SRP-dependent Cotranslational Protein Targeting To Membrane, Translocation Intracellular Protein Transport Protein Transport Retrograde Protein Transport, ER To Cytosol Post-translational Protein Targeting To Membrane, Translocation ERAD Pathway
Pathways		Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	ER-Phagosome pathway SRP-dependent cotranslational protein targeting to membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Drugs
Diseases
GWAS		PR interval ( 32439900)	Adult body size ( 32376654) Asthma ( 31959851) Callous-unemotional behaviour ( 23874384) Gestational age at birth (maternal effect) ( 28877031) HDL cholesterol levels ( 32203549) Smoking status (ever vs never smokers) ( 30643258) Triglyceride levels ( 32203549)
Interacting Genes		29 interacting genes: AIRIM AKT1 ATP5PD CAPNS1 CDKN1A CEBPA CEP126 DUSP21 EEF1G ENKD1 FBN1 FBXO7 FLYWCH2 GIT2 KAT5 KIFC2 KRTAP9-3 NUP85 PLK1 PRKAB2 PRKCSH PTMS SDCBP SEC61B SNCAIP SOD2 TMEM256 TTR UBAC2	19 interacting genes: APOB ARL6 ATP13A2 AURKA BAG6 BMPR1A BUB1 CALM1 CDKN2A FBXW7 GET3 GET4 MCC MLH3 MUTYH SEC63 SERP1 SPC25 TRAM1
Entrez ID		51608	10952
HPRD ID		12909	06715
Ensembl ID		ENSG00000239857	ENSG00000106803
Uniprot IDs		Q7L5D6	P60468
PDB IDs		6AU8 7RU9 7RUA 7RUC	6W6L 8B6L 8DNV 8DNW 8DNX 8DNY 8DNZ 8DO0 8DO1 8DO2 8DO3 8OJ0 8OJ8
Enriched GO Terms of Interacting Partners?		Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Establishment Of Spindle Orientation Establishment Of Mitotic Spindle Localization Microtubule Cytoskeleton Organization Involved In Mitosis Establishment Of Mitotic Spindle Orientation Establishment Of Spindle Localization Response To Nutrient Levels Spindle Localization Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Protein Localization To Nucleus Establishment Of Protein Localization To Organelle Carbohydrate Homeostasis Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Glucose Homeostasis Protein Localization To Endoplasmic Reticulum Regulation Of Macroautophagy Microtubule-based Process Positive Regulation Of Protein Modification Process	Protein Targeting To Membrane Protein Insertion Into ER Membrane Establishment Of Protein Localization To Membrane Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Tail-anchored Membrane Protein Insertion Into ER Membrane Protein Insertion Into Membrane Regulation Of Protein Stability Protein Targeting BAT3 Complex Protein Targeting To ER Establishment Of Protein Localization Maintenance Of Unfolded Protein Establishment Of Protein Localization To Endoplasmic Reticulum Localization Within Membrane Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Protein Carrier Chaperone Intracellular Protein Localization Nucleoplasm Post-embryonic Development Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Cell Cycle Phase Transition Regulation Of Cell Cycle Process Protein Stabilization Cotranslational Protein Targeting To Membrane Regulation Of Mitotic Cell Cycle Outer Kinetochore Cellular Response To Stress Response To Stress Synaptonemal Complex Assembly Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Mitotic Nuclear Division Synaptonemal Complex Organization Negative Regulation Of Protein Catabolic Process Protein Catabolic Process Mitotic Spindle Assembly Checkpoint Signaling Chromosome Organization Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Nuclear Division Negative Regulation Of Proteolysis Mismatch Repair Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Intracellular Protein Transmembrane Transport Negative Regulation Of Mitotic Metaphase/anaphase Transition Mitotic Cell Cycle Phase Transition Negative Regulation Of Epithelial Cell Proliferation Mature Chylomicron Lipid Homeostasis Cellular Localization
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