GET4 and PRKCSH

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		GET4	PRKCSH
Gene Name		golgi to ER traffic protein 4 homolog (S. cerevisiae)	protein kinase C substrate 80K-H
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol BAT3 Complex	Intracellular Endoplasmic Reticulum Endoplasmic Reticulum Lumen
	Molecular Function		Protein Kinase C Binding Calcium Ion Binding Ion Channel Binding Phosphoprotein Binding
	Biological Process	Transport Tail-anchored Membrane Protein Insertion Into ER Membrane	Protein Folding N-glycan Processing Protein N-linked Glycosylation Via Asparagine Intracellular Signal Transduction Post-translational Protein Modification Cellular Protein Metabolic Process Innate Immune Response
Pathways			Diseases of glycosylation Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS) Defective MGAT2 causes MGAT2-CDG (CDG-2a) Defective ALG1 causes ALG1-CDG (CDG-1k) Defective MOGS causes MOGS-CDG (CDG-2b) Defective ALG9 causes ALG9-CDG (CDG-1l) Defective MAN1B1 causes MRT15 N-glycan trimming in the ER and Calnexin/Calreticulin cycle Advanced glycosylation endproduct receptor signaling Defective ALG11 causes ALG11-CDG (CDG-1p) Innate Immune System Defective ALG2 causes ALG2-CDG (CDG-1i) Post-translational protein modification Defective ALG3 causes ALG3-CDG (CDG-1d) Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2 Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective RFT1 causes RFT1-CDG (CDG-1n) Defective ALG6 causes ALG6-CDG (CDG-1c) Asparagine N-linked glycosylation Defective ALG8 causes ALG8-CDG (CDG-1h) Defective MPDU1 causes MPDU1-CDG (CDG-1f) Defective ALG12 causes ALG12-CDG (CDG-1g) Diseases associated with N-glycosylation of proteins Calnexin/calreticulin cycle
Drugs
Diseases
GWAS
Protein-Protein Interactions		17 interactors: ATP5H CAPNS1 CDKN1A EEF1G KAT5 KIAA1377 KIFC2 PLK1 PRKAB2 PRKCSH PTMS SEC61B SNCAIP SOD2 TMEM256 TTR UBAC2	9 interactors: ARL4D CANX GANAB GBA3 GET4 PTPRC RGS2 RPS6 VDR
Entrez ID		51608	5589
HPRD ID		12909	03518
Ensembl ID		ENSG00000239857	ENSG00000130175
Uniprot IDs		Q7L5D6	K7ELL7 P14314
PDB IDs
Enriched GO Terms of Interacting Partners?		Response To Ionizing Radiation Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Response To Hyperoxia Response To Radiation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Vasodilation By Acetylcholine Involved In Regulation Of Systemic Arterial Blood Pressure Erythrophore Differentiation Age-dependent Response To Reactive Oxygen Species Energy Derivation By Oxidation Of Organic Compounds	T Cell Differentiation In Thymus T Cell Proliferation Protein N-linked Glycosylation Via Asparagine Vitamin D Receptor Signaling Pathway Immunoglobulin Biosynthetic Process Positive Regulation Of Hematopoietic Stem Cell Migration Lymphocyte Proliferation Mononuclear Cell Proliferation Protein N-linked Glycosylation Cellular Localization Leukocyte Proliferation Protein Secretion Positive Regulation Of Vitamin D 24-hydroxylase Activity Bile Acid Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Secretion Establishment Of Protein Localization T Cell Differentiation Positive Regulation Of Apoptotic Process Involved In Mammary Gland Involution Activation-induced Cell Death Of T Cells Regulation Of Adrenergic Receptor Signaling Pathway Oogenesis Stage Negative Regulation Of T Cell Mediated Cytotoxicity Placenta Development Mammary Gland Branching Involved In Pregnancy Tail-anchored Membrane Protein Insertion Into ER Membrane Positive Regulation Of Cardiac Muscle Contraction Regulation Of Calcidiol 1-monooxygenase Activity Positive Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Glycoside Catabolic Process Positive Regulation Of Isotype Switching To IgG Isotypes Bone Marrow Development Post-translational Protein Modification Multicellular Organismal Reproductive Process Negative Regulation Of Protein Kinase Activity Negative Regulation Of CAMP-mediated Signaling Negative Regulation Of Phospholipase Activity Multicellular Organism Reproduction Protein Insertion Into ER Membrane Negative Regulation Of Kinase Activity Establishment Of Protein Localization To Membrane Chemical Homeostasis Lymphocyte Differentiation Positive Regulation Of Gamma-delta T Cell Differentiation T Cell Proliferation Involved In Immune Response Negative Regulation Of Cell Adhesion Involved In Substrate-bound Cell Migration Relaxation Of Vascular Smooth Muscle Regulation Of Isotype Switching To IgG Isotypes
Tagcloud ?		anchored captured cascades details disassembled drive driving effectors energies ensure exemplified get3 gradients guided inputs machineries monitor ordered partners principles recycling requirement sequentially successive ta targeting unidentified vectorial	abolished antisense axial coreceptors deglycosylation dickkopf1 dkk1 endoplasmic erlectin glycan glycoprotein head homology kremen1 krm1 krm2 mannose member morpholino mrh organogenesis proteomic resident reticulum reveals synexpression traffic xenopus xtp3
Tagcloud (Difference) ?		anchored captured cascades details disassembled drive driving effectors energies ensure exemplified get3 gradients guided inputs machineries monitor ordered partners principles recycling requirement sequentially successive ta targeting unidentified vectorial	abolished antisense axial coreceptors deglycosylation dickkopf1 dkk1 endoplasmic erlectin glycan glycoprotein head homology kremen1 krm1 krm2 mannose member morpholino mrh organogenesis proteomic resident reticulum reveals synexpression traffic xenopus xtp3
Tagcloud (Intersection) ?