GET4 and SOD2

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
HPRD (two hybrid)

		GET4	SOD2
Description		guided entry of tail-anchored proteins factor 4	superoxide dismutase 2
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GO Annotations	Cellular Component	Nucleoplasm Chromosome Nucleolus Cytoplasm Cytosol BAT3 Complex	Mitochondrion Mitochondrial Matrix Mitochondrial Nucleoid Extracellular Exosome
	Molecular Function	Protein Binding Protein-folding Chaperone Binding Protein Carrier Chaperone	DNA Binding Superoxide Dismutase Activity Protein Binding Oxidoreductase Activity Oxygen Binding Enzyme Binding Manganese Ion Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Regulation Of Protein Stability ERAD Pathway Maintenance Of Unfolded Protein Protein Insertion Into ER Membrane Tail-anchored Membrane Protein Insertion Into ER Membrane	Response To Reactive Oxygen Species Response To Superoxide Response To Hypoxia Release Of Cytochrome C From Mitochondria Liver Development Detection Of Oxygen Acetylcholine-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure Regulation Of Transcription By RNA Polymerase II Glutathione Metabolic Process Superoxide Metabolic Process Response To Oxidative Stress Mitochondrion Organization Heart Development Locomotory Behavior Regulation Of Blood Pressure Negative Regulation Of Cell Population Proliferation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Apoptotic Mitochondrial Changes Response To Xenobiotic Stimulus Post-embryonic Development Response To Manganese Ion Response To Zinc Ion Response To Selenium Ion Response To Gamma Radiation Positive Regulation Of Hydrogen Peroxide Biosynthetic Process Response To Activity Removal Of Superoxide Radicals Respiratory Electron Transport Chain Hemopoiesis Positive Regulation Of Cell Migration Response To Nutrient Levels Intracellular Oxygen Homeostasis Response To Lipopolysaccharide Response To L-ascorbic Acid Response To Silicon Dioxide Cellular Response To Oxidative Stress Response To Isolation Stress Response To Immobilization Stress Vasodilation Response To Hydrogen Peroxide Superoxide Anion Generation Hydrogen Peroxide Metabolic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Negative Regulation Of Fat Cell Differentiation Response To Cadmium Ion Negative Regulation Of Fibroblast Proliferation Neuron Development Response To Axon Injury Erythrophore Differentiation Hydrogen Peroxide Biosynthetic Process Protein Homotetramerization Response To Electrical Stimulus Regulation Of Mitochondrial Membrane Potential Response To Hyperoxia Multicellular Organismal-level Iron Ion Homeostasis Response To Magnetism Cellular Response To Ethanol Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Membrane Hyperpolarization Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process Positive Regulation Of Vascular Associated Smooth Muscle Cell Differentiation Involved In Phenotypic Switching
Pathways		Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	Transcriptional activation of mitochondrial biogenesis Detoxification of Reactive Oxygen Species Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes Mitochondrial unfolded protein response (UPRmt)
Drugs			Benzylsulfonic acid 3-Fluoro-L-tyrosine Benzoyl peroxide
Diseases
GWAS		PR interval ( 32439900)	Age-related macular degeneration (geographic atrophy) ( 22705344) Erosive tooth wear (severe vs non-severe) ( 29898447) Lipoprotein (a) levels ( 26377243) Plasma anti-thyroglobulin and anti-thyroid peroxidase levels (bivariate analysis) ( 29678681) Polycystic ovary syndrome ( 32289280) Pulse pressure ( 27841878)
Interacting Genes		29 interacting genes: AIRIM AKT1 ATP5PD CAPNS1 CDKN1A CEBPA CEP126 DUSP21 EEF1G ENKD1 FBN1 FBXO7 FLYWCH2 GIT2 KAT5 KIFC2 KRTAP9-3 NUP85 PLK1 PRKAB2 PRKCSH PTMS SDCBP SEC61B SNCAIP SOD2 TMEM256 TTR UBAC2	9 interacting genes: APP CEP70 CYP4F12 GET4 HDHD2 KIAA1549 NOL12 RAB4A RPS3A
Entrez ID		51608	6648
HPRD ID		12909	00938
Ensembl ID		ENSG00000239857	ENSG00000291237
Uniprot IDs		Q7L5D6	A0A384NL29 G5E9P6 P04179 Q96AM7
PDB IDs		6AU8 7RU9 7RUA 7RUC	1AP5 1AP6 1EM1 1JA8 1LUV 1LUW 1MSD 1N0J 1N0N 1PL4 1PM9 1QNM 1SZX 1VAR 1XDC 1XIL 1ZSP 1ZTE 1ZUQ 2ADP 2ADQ 2GDS 2P4K 2QKA 2QKC 3C3S 3C3T 5GXO 5T30 5VF9 7KKS 7KKU 7KKW 7KLB 8SKS 8VHW 8VHY 8VJ0 8VJ4 8VJ5 8VJ8 9BVY 9BW2 9BWM 9BWQ 9BWR
Enriched GO Terms of Interacting Partners?		Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Establishment Of Spindle Orientation Establishment Of Mitotic Spindle Localization Microtubule Cytoskeleton Organization Involved In Mitosis Establishment Of Mitotic Spindle Orientation Establishment Of Spindle Localization Response To Nutrient Levels Spindle Localization Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Protein Localization To Nucleus Establishment Of Protein Localization To Organelle Carbohydrate Homeostasis Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Glucose Homeostasis Protein Localization To Endoplasmic Reticulum Regulation Of Macroautophagy Microtubule-based Process Positive Regulation Of Protein Modification Process
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