MED15 and PLSCR1

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		MED15	PLSCR1
Gene Name		mediator complex subunit 15	phospholipid scramblase 1
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Membrane Mediator Complex	Nucleus Nucleolus Golgi Apparatus Cytosol Plasma Membrane Integral Component Of Plasma Membrane Membrane Extracellular Matrix Membrane Raft Extracellular Vesicular Exosome
	Molecular Function	RNA Polymerase II Transcription Cofactor Activity Protein Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding Epidermal Growth Factor Receptor Binding Calcium Ion Binding Protein Binding SH3 Domain Binding Phospholipid Scramblase Activity Enzyme Binding CD4 Receptor Binding
	Biological Process	Regulation Of Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Gene Expression Stem Cell Maintenance	Phosphatidylserine Biosynthetic Process Apoptotic Process Acute-phase Response Positive Regulation Of Gene Expression Phospholipid Scrambling Platelet Activation Regulation Of Mast Cell Activation Response To Interferon-beta Negative Regulation Of Viral Genome Replication Positive Regulation Of Innate Immune Response Positive Regulation Of Transcription From RNA Polymerase II Promoter Defense Response To Virus Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Positive Regulation Of DNA Topoisomerase (ATP-hydrolyzing) Activity
Pathways		PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Drugs
Diseases
GWAS
Protein-Protein Interactions		12 interactors: ATP5C1 ATXN1 CTDP1 FHL3 MED25 MLLT6 PLSCR1 RELA SMAD2 SMAD3 TRIM11 UBC	125 interactors: ABL1 ADAMTSL4 ADCY7 ANXA11 APP ARNT2 ATG12 ATN1 BACE1 BCL6B C10orf10 C10orf54 C10orf62 CATSPER1 CCDC33 CCER1 CDC42EP1 CHRD CNTFR CPSF3L CPSF6 CRK CRKL CRY1 CTBP1-AS2 CTSZ DAZAP2 DEF6 DHRS1 DLK2 DMRT3 DOCK2 DTX2 EFEMP2 EGFR ENKD1 EP300 ESR2 EWSR1 EXD3 FAM103A1 FBLN1 FBXL18 FRAT1 FRS3 GDPD5 GLRX3 GNAI2 GPRIN2 HEY2 HOXA1 HOXA9 HOXB6 HRG ILF3 IP6K2 KIAA1683 KIF1A KRTAP10-11 KRTAP10-3 KRTAP10-9 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP5-6 KRTAP9-2 LASP1 LCE2D LCE3C LCE4A LGALS9C LINC00663 LINC01547 LONRF1 MAPK6 MED15 MGAT5B MVP NECAP2 NEU4 NOC4L NPDC1 NR0B2 NTN4 OGDH P2RY6 PCED1A PGLS PHLDA1 PITX1 PKD2 PLSCR3 PLSCR4 PML PRKCD PRR13 RASD1 RBL1 RERE RGS3 SCNM1 SF1 SHC1 SLC25A6 SLC35A2 SLPI SMARCC1 SMCP SPATA8 SPG7 SPRY2 SRC STK16 TFG TRAF4 TRIM42 VASP VPS37C YIPF3 ZBTB16 ZNF417 ZNF581 ZNF587 ZNF638 ZNF764
Entrez ID		51586	5359
HPRD ID		12117	08855
Ensembl ID		ENSG00000099917	ENSG00000188313
Uniprot IDs		B4DGD6 G3V1P5 Q96RN5	B4DTE8 O15162
PDB IDs		2GUT	1Y2A
Enriched GO Terms of Interacting Partners?		Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Transcription Initiation From RNA Polymerase II Promoter Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Transcription, DNA-templated Primary MiRNA Processing RNA Biosynthetic Process DNA-templated Transcription, Initiation SMAD Protein Complex Assembly Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Gene Expression Positive Regulation Of Cellular Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Paraxial Mesoderm Morphogenesis Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Cellular Metabolic Process Regulation Of Transcription, DNA-templated Nodal Signaling Pathway Regulation Of Nucleic Acid-templated Transcription RNA Metabolic Process Embryonic Foregut Morphogenesis Foregut Morphogenesis Transforming Growth Factor Beta Receptor Signaling Pathway Paraxial Mesoderm Development Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Production Of MiRNAs Involved In Gene Silencing By MiRNA Gene Expression Regulation Of Viral Process Positive Regulation Of Chondrocyte Differentiation Pericardium Development Defense Response To Virus Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Nucleotide-binding Oligomerization Domain Containing Signaling Pathway	Regulation Of Nitrogen Compound Metabolic Process Organ Development RNA Metabolic Process Transcription, DNA-templated Regulation Of Kinase Activity Enzyme Linked Receptor Protein Signaling Pathway Gene Expression Developmental Process RNA Biosynthetic Process Multicellular Organismal Development Regulation Of Protein Kinase Activity Regulation Of Transcription, DNA-templated Regulation Of Signaling Cellular Response To Organic Substance ERBB Signaling Pathway Regulation Of Nucleic Acid-templated Transcription System Development Regulation Of RNA Biosynthetic Process Cellular Response To Growth Factor Stimulus Regulation Of RNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Response To Growth Factor Cellular Macromolecule Biosynthetic Process Regulation Of Signal Transduction Regulation Of Protein Phosphorylation Regulation Of Gene Expression Nucleobase-containing Compound Metabolic Process Macromolecule Biosynthetic Process Central Nervous System Development Response To Organic Substance Cellular Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Anatomical Structure Development Pattern Specification Process Cellular Process Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Phosphorylation Fibroblast Growth Factor Receptor Signaling Pathway Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of MAPK Cascade Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Cellular Protein Metabolic Process Nitrogen Compound Metabolic Process Positive Regulation Of MAPK Cascade Cellular Response To Fibroblast Growth Factor Stimulus Activation Of Protein Kinase Activity Platelet Activation
Tagcloud ?		9aatad 9aatads alignment ambiguous analogy architecture belong cmyb differently e2a formations foxo3 gcn4 heb helical kix leucine mll oaf1 pdr1 plausible position requirements resolved shares shed structural tad transactivation	actions adaptor adding anchorage attenuation blocking colorectal crc crcs dephosphorylation effectors erks g1 ht29 led monoclonal np1 overexpressed phospholipid retinoblastoma scramblase serve shc src terminus trafficking treating tumorigenesis tumorigenic
Tagcloud (Difference) ?		9aatad 9aatads alignment ambiguous analogy architecture belong cmyb differently e2a formations foxo3 gcn4 heb helical kix leucine mll oaf1 pdr1 plausible position requirements resolved shares shed structural tad transactivation	actions adaptor adding anchorage attenuation blocking colorectal crc crcs dephosphorylation effectors erks g1 ht29 led monoclonal np1 overexpressed phospholipid retinoblastoma scramblase serve shc src terminus trafficking treating tumorigenesis tumorigenic
Tagcloud (Intersection) ?